Blood Group Substances
Their Chemistry and Immunochemistry
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Blood Group Substances: Their Chemistry and Immunochemistry focuses on the characteristics, reactions, sources, and transformations of blood group substances. The book first offers information on human blood group factors and the methods and reagents used in testing for blood group antibodies and antigens. Topics include autoantibody formation and hemolytic anemia, panagglutinable erythrocytes, effects of temperature on hemagglutination, and effects of periodate on blood group substances. The text also ponders on the sources and purification of blood group substances. The publication examines the chemical and immunochemical characterization of blood group substances and immunochemical similarities and differences among blood group substances from various species. The text then takes a look at antibodies to blood group substances and their biological effects, including purification and concentration of blood group antibodies; studies with antibodies labeled with radioactive isotopes; and passage of antibodies through the placenta. The manuscript is a valuable reference for readers interested in blood group substances.
Table of Contents
Preface
1. Introduction. The Human Blood Group Factors
The ABO System
Other Blood Group Systems
Isoimmunization and the Discovery of Blood Group Systems
Isoimmunization in Other Animals
Panagglutinable Erythrocytes
Erythrocyte Mosaicism
Actively Acquired Tolerance to Foreign Cells
Autoantibody Formation and Hemolytic Anemia
Genetic Basis of Blood Grouping
References
2. Methods and Reagents Used in Testing for Blood Group Antibodies and Antigens
Hemagglutination Tests for "Blocking" Antibody
Potency of Antisera for Blood Grouping
Effects of Temperature on Hemagglutination
Assay for Blood Group Substances in Solution
Estimation of Antibody Nitrogen Content of Antisera
Estimation of Blood Group Substances
Estimation of the Degree of Precipitability of an Antigen by Excess Antibody
Elution of Antibodies from Erythrocytes
Preparation of Human Antisera to the Various Blood Group Substances in Humans
Antisera for the Coombs Test
Miscellaneous Sera and Materials Reacting with Blood Group Antigens
Enzymes Splitting Blood Group Substances
Effect of Periodate on'Blood Group Substances
References
3. Sources of Blood Group Substances
A, B, O (H), and Lea Substances
Other Blood Group Substances
References
4. Purification of Blood Group Substances
Substances from Erythrocytes
Blood Group A, B, O (H), and Lea Substances from Glandular Tissues and from Secretions
Recommended Procedures for the Purification of Blood Group A, B, O (H), or Lea Substances from Tissues or Secretions
A and O Substances from Hog Gastric Mucosa
A, B, O (H), and Lea Substances from Human Saliva or Amniotic Fluid
A, B, and Inactive Substances from Horse Gastric Mucosa
A, B, O (H), and Lea Substances from Pseudomucinous Ovarian Cyst Fluids
Blood Group Substances from Meconium
References
5. Chemical Composition and Properties of the Blood Group A, B, O (H) and Lea Preparations
References
6. Chemical and Immunochemical Characterization of the Blood Group Substances-Evidence of Purity
Chemical Characterization
Immunochemical Characterization
References
7. Immunochemical Similarities and Differences among Blood Group Substances from Various Species
Differences by Hemagglutination Inhibition
Differences by Quantitative Precipitin Tests
Cross Reactivity with Type XIV Antipneumococcal Serum
Antigenicity Differences
Relation to the J Factor and the R and r Factors of Sheep
References
8. Some Features of the Structure of the Blood Group A, B, O (H) and Lea Substances
Structural Changes Produced by Mild Acid Hydrolysis
Structural Changes Produced by Sodium Carbonate
Structural Changes Produced by Enzymes Splitting Blood Group Substances
Structural Information Obtained from Studies on Inhibition with Simple Sugars of Hemagglutination by Plant Agglutinins and Antibodies
Structural Information from Studies on the Inhibition of Blood Group Splitting Enzymes by Simple Sugars
Periodate Oxidation
References
9. Antibodies to Blood Group Substances and their Biological Effects
Saline Agglutinating and Blocking Antibodies
"Linked" Anti-A and Anti-B
Purification and Concentration of Blood Group Antibodies
Properties of Blood Group Antibodies
Passage of Antibodies through the Placenta
Thermodynamic Studies on Anti-A and Anti-B
Studies with Antibodies Labeled with Radioactive Isotopes
Miscellaneous Applications of Blocking Antibody
References
10. Biological Effects and Uses of Blood Group Substances-Materials of Similar Chemical Composition
Effects of Injection of A and B Substances
Blood Group Substances and their Relation to Intrinsic Factor
Relationship of Blood Group Substances to the Virulence-Enhancing Factors in Hog Gastric Mucosa
Relation of Blood Group Substances to Materials Inhibiting the Action of Various Viruses
Miscellaneous Activities Reported to Be Associated with Blood Group Substances; Substances with Constituents Present in Blood Group Substances
References
Index
Product details
- No. of pages: 340
- Language: English
- Copyright: © Academic Press 1955
- Published: January 1, 1955
- Imprint: Academic Press
- eBook ISBN: 9781483274263