Blood Group Substances

Blood Group Substances

Their Chemistry and Immunochemistry

1st Edition - January 1, 1955

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  • Author: Elvin A. Kabat
  • eBook ISBN: 9781483274263

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Blood Group Substances: Their Chemistry and Immunochemistry focuses on the characteristics, reactions, sources, and transformations of blood group substances. The book first offers information on human blood group factors and the methods and reagents used in testing for blood group antibodies and antigens. Topics include autoantibody formation and hemolytic anemia, panagglutinable erythrocytes, effects of temperature on hemagglutination, and effects of periodate on blood group substances. The text also ponders on the sources and purification of blood group substances. The publication examines the chemical and immunochemical characterization of blood group substances and immunochemical similarities and differences among blood group substances from various species. The text then takes a look at antibodies to blood group substances and their biological effects, including purification and concentration of blood group antibodies; studies with antibodies labeled with radioactive isotopes; and passage of antibodies through the placenta. The manuscript is a valuable reference for readers interested in blood group substances.

Table of Contents

  • Preface

    1. Introduction. The Human Blood Group Factors

    The ABO System

    Other Blood Group Systems

    Isoimmunization and the Discovery of Blood Group Systems

    Isoimmunization in Other Animals

    Panagglutinable Erythrocytes

    Erythrocyte Mosaicism

    Actively Acquired Tolerance to Foreign Cells

    Autoantibody Formation and Hemolytic Anemia

    Genetic Basis of Blood Grouping


    2. Methods and Reagents Used in Testing for Blood Group Antibodies and Antigens

    Hemagglutination Tests for "Blocking" Antibody

    Potency of Antisera for Blood Grouping

    Effects of Temperature on Hemagglutination

    Assay for Blood Group Substances in Solution

    Estimation of Antibody Nitrogen Content of Antisera

    Estimation of Blood Group Substances

    Estimation of the Degree of Precipitability of an Antigen by Excess Antibody

    Elution of Antibodies from Erythrocytes

    Preparation of Human Antisera to the Various Blood Group Substances in Humans

    Antisera for the Coombs Test

    Miscellaneous Sera and Materials Reacting with Blood Group Antigens

    Enzymes Splitting Blood Group Substances

    Effect of Periodate on'Blood Group Substances


    3. Sources of Blood Group Substances

    A, B, O (H), and Lea Substances

    Other Blood Group Substances


    4. Purification of Blood Group Substances

    Substances from Erythrocytes

    Blood Group A, B, O (H), and Lea Substances from Glandular Tissues and from Secretions

    Recommended Procedures for the Purification of Blood Group A, B, O (H), or Lea Substances from Tissues or Secretions

    A and O Substances from Hog Gastric Mucosa

    A, B, O (H), and Lea Substances from Human Saliva or Amniotic Fluid

    A, B, and Inactive Substances from Horse Gastric Mucosa

    A, B, O (H), and Lea Substances from Pseudomucinous Ovarian Cyst Fluids

    Blood Group Substances from Meconium


    5. Chemical Composition and Properties of the Blood Group A, B, O (H) and Lea Preparations


    6. Chemical and Immunochemical Characterization of the Blood Group Substances-Evidence of Purity

    Chemical Characterization

    Immunochemical Characterization


    7. Immunochemical Similarities and Differences among Blood Group Substances from Various Species

    Differences by Hemagglutination Inhibition

    Differences by Quantitative Precipitin Tests

    Cross Reactivity with Type XIV Antipneumococcal Serum

    Antigenicity Differences

    Relation to the J Factor and the R and r Factors of Sheep


    8. Some Features of the Structure of the Blood Group A, B, O (H) and Lea Substances

    Structural Changes Produced by Mild Acid Hydrolysis

    Structural Changes Produced by Sodium Carbonate

    Structural Changes Produced by Enzymes Splitting Blood Group Substances

    Structural Information Obtained from Studies on Inhibition with Simple Sugars of Hemagglutination by Plant Agglutinins and Antibodies

    Structural Information from Studies on the Inhibition of Blood Group Splitting Enzymes by Simple Sugars

    Periodate Oxidation


    9. Antibodies to Blood Group Substances and their Biological Effects

    Saline Agglutinating and Blocking Antibodies

    "Linked" Anti-A and Anti-B

    Purification and Concentration of Blood Group Antibodies

    Properties of Blood Group Antibodies

    Passage of Antibodies through the Placenta

    Thermodynamic Studies on Anti-A and Anti-B

    Studies with Antibodies Labeled with Radioactive Isotopes

    Miscellaneous Applications of Blocking Antibody


    10. Biological Effects and Uses of Blood Group Substances-Materials of Similar Chemical Composition

    Effects of Injection of A and B Substances

    Blood Group Substances and their Relation to Intrinsic Factor

    Relationship of Blood Group Substances to the Virulence-Enhancing Factors in Hog Gastric Mucosa

    Relation of Blood Group Substances to Materials Inhibiting the Action of Various Viruses

    Miscellaneous Activities Reported to Be Associated with Blood Group Substances; Substances with Constituents Present in Blood Group Substances



Product details

  • No. of pages: 340
  • Language: English
  • Copyright: © Academic Press 1955
  • Published: January 1, 1955
  • Imprint: Academic Press
  • eBook ISBN: 9781483274263

About the Author

Elvin A. Kabat

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