Blood Group Substances - 1st Edition - ISBN: 9781483229331, 9781483274263

Blood Group Substances

1st Edition

Their Chemistry and Immunochemistry

Authors: Elvin A. Kabat
eBook ISBN: 9781483274263
Imprint: Academic Press
Published Date: 1st January 1955
Page Count: 340
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Blood Group Substances: Their Chemistry and Immunochemistry focuses on the characteristics, reactions, sources, and transformations of blood group substances.
The book first offers information on human blood group factors and the methods and reagents used in testing for blood group antibodies and antigens. Topics include autoantibody formation and hemolytic anemia, panagglutinable erythrocytes, effects of temperature on hemagglutination, and effects of periodate on blood group substances. The text also ponders on the sources and purification of blood group substances.
The publication examines the chemical and immunochemical characterization of blood group substances and immunochemical similarities and differences among blood group substances from various species. The text then takes a look at antibodies to blood group substances and their biological effects, including purification and concentration of blood group antibodies; studies with antibodies labeled with radioactive isotopes; and passage of antibodies through the placenta.
The manuscript is a valuable reference for readers interested in blood group substances.

Table of Contents


1. Introduction. The Human Blood Group Factors

The ABO System

Other Blood Group Systems

Isoimmunization and the Discovery of Blood Group Systems

Isoimmunization in Other Animals

Panagglutinable Erythrocytes

Erythrocyte Mosaicism

Actively Acquired Tolerance to Foreign Cells

Autoantibody Formation and Hemolytic Anemia

Genetic Basis of Blood Grouping


2. Methods and Reagents Used in Testing for Blood Group Antibodies and Antigens

Hemagglutination Tests for "Blocking" Antibody

Potency of Antisera for Blood Grouping

Effects of Temperature on Hemagglutination

Assay for Blood Group Substances in Solution

Estimation of Antibody Nitrogen Content of Antisera

Estimation of Blood Group Substances

Estimation of the Degree of Precipitability of an Antigen by Excess Antibody

Elution of Antibodies from Erythrocytes

Preparation of Human Antisera to the Various Blood Group Substances in Humans

Antisera for the Coombs Test

Miscellaneous Sera and Materials Reacting with Blood Group Antigens

Enzymes Splitting Blood Group Substances

Effect of Periodate on'Blood Group Substances


3. Sources of Blood Group Substances

A, B, O (H), and Lea Substances

Other Blood Group Substances


4. Purification of Blood Group Substances

Substances from Erythrocytes

Blood Group A, B, O (H), and Lea Substances from Glandular Tissues and from Secretions

Recommended Procedures for the Purification of Blood Group A, B, O (H), or Lea Substances from Tissues or Secretions

A and O Substances from Hog Gastric Mucosa

A, B, O (H), and Lea Substances from Human Saliva or Amniotic Fluid

A, B, and Inactive Substances from Horse Gastric Mucosa

A, B, O (H), and Lea Substances from Pseudomucinous Ovarian Cyst Fluids

Blood Group Substances from Meconium


5. Chemical Composition and Properties of the Blood Group A, B, O (H) and Lea Preparations


6. Chemical and Immunochemical Characterization of the Blood Group Substances-Evidence of Purity

Chemical Characterization

Immunochemical Characterization


7. Immunochemical Similarities and Differences among Blood Group Substances from Various Species

Differences by Hemagglutination Inhibition

Differences by Quantitative Precipitin Tests

Cross Reactivity with Type XIV Antipneumococcal Serum

Antigenicity Differences

Relation to the J Factor and the R and r Factors of Sheep


8. Some Features of the Structure of the Blood Group A, B, O (H) and Lea Substances

Structural Changes Produced by Mild Acid Hydrolysis

Structural Changes Produced by Sodium Carbonate

Structural Changes Produced by Enzymes Splitting Blood Group Substances

Structural Information Obtained from Studies on Inhibition with Simple Sugars of Hemagglutination by Plant Agglutinins and Antibodies

Structural Information from Studies on the Inhibition of Blood Group Splitting Enzymes by Simple Sugars

Periodate Oxidation


9. Antibodies to Blood Group Substances and their Biological Effects

Saline Agglutinating and Blocking Antibodies

"Linked" Anti-A and Anti-B

Purification and Concentration of Blood Group Antibodies

Properties of Blood Group Antibodies

Passage of Antibodies through the Placenta

Thermodynamic Studies on Anti-A and Anti-B

Studies with Antibodies Labeled with Radioactive Isotopes

Miscellaneous Applications of Blocking Antibody


10. Biological Effects and Uses of Blood Group Substances-Materials of Similar Chemical Composition

Effects of Injection of A and B Substances

Blood Group Substances and their Relation to Intrinsic Factor

Relationship of Blood Group Substances to the Virulence-Enhancing Factors in Hog Gastric Mucosa

Relation of Blood Group Substances to Materials Inhibiting the Action of Various Viruses

Miscellaneous Activities Reported to Be Associated with Blood Group Substances; Substances with Constituents Present in Blood Group Substances




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© Academic Press 1955
Academic Press
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About the Author

Elvin A. Kabat

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