Blood Gases and Critical Care Testing

Blood Gases and Critical Care Testing

Physiology, Clinical Interpretations, and Laboratory Applications

3rd Edition - October 8, 2021

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  • Authors: John Toffaletti, Craig Rackley
  • eBook ISBN: 9780323903844
  • Paperback ISBN: 9780323899710

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Blood gas tests are a group of tests that are widely used and essential for the evaluation and management of a patient’s ventilation, oxygenation, and acid-base balance, often in emergent situations, and along with blood gases are other critical care analytes measured on blood: calcium, magnesium, phosphate, and lactate. Blood Gases and Critical Care Testing: Clinical Interpretations and Laboratory Applications, Third Edition, serves as your single most important reference for understanding blood gases and critical care testing and interpretation.  The third edition of this classic book is a complete revision and provides the fundamentals of blood gas (pH, pCO2, pO2) and other critical care tests (calcium, magnesium, phosphate, and lactate), including the history, the definitions, the physiology, and practical information on sample handling, quality control and reference intervals. Case examples with clear clinical interpretations of critical care tests have been included to all chapters.  This book will serve as a valuable and convenient resource for clinical laboratory scientists in understanding the physiology and clinical use of these critical care tests and for providing practical guidelines for successful routine testing and quality monitoring of these tests. 

Key Features

  • Provides a step-by-step approach for organizing and evaluating clinical blood gas and critical care test results
  • Describes several calculated parameters that are used by clinicians for evaluating a patient’s pulmonary function and oxygenation status and discusses clinical examples of their use
  • This new edition includes more detailed information about reference intervals, not only for arterial blood, but for venous blood and umbilical cord blood, and for pH in body fluids
  • Covers practical information on sample handling and quality control issues for blood gas testing


Pathologists, clinical chemists, clinical laboratory scientists, graduate students in laboratory studies, critical care physicians. Respiratory therapists, physicians in pulmonary medicine

Table of Contents

  • 1. Introduction to Blood Gases and Blood Gas Physiology
    2. Physiologic Mechanisms and Diagnostic Approach to Acid-Base Disorders
    3. Interpreting Blood Gas Results on Venous, Capillary, and Umbilical Cord Blood
    4. Disorders of Oxygenation: Hypoxemia and Tissue Hypoxia
    5. Calcium Physiology and Diagnostic Evaluation
    6. Magnesium Physiology and Diagnostic Evaluation
    7. Phosphate Physiology and Diagnostic Evaluation
    8. Osmolality, Sodium, Potassium, Chloride, and Bicarbonate Osmolality and Volume Regulation
    9. Lactate Physiology and Diagnostic Evaluation
    10. Collection and Handling of Samples: Effects on Blood Gases and Electrolytes: Na, K, Ionized Ca, Mg, Lactate, Phosphate Analysis
    11. Quality Control in Blood Gas and Critical Care Testing
    12. Models for Point of Care Testing for Critical Care Analytes

Product details

  • No. of pages: 264
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: October 8, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780323903844
  • Paperback ISBN: 9780323899710

About the Authors

John Toffaletti

John G. Toffaletti received a BS from the University of Florida in Gainesville and followed this with training in clinical chemistry at the University of North Carolina at Chapel Hill, where he earned a PhD in Biochemistry, then completed a Postdoctoral Fellowship in Clinical Chemistry at Hartford Hospital. Since completing these programs, he has worked in the Clinical Laboratories at Duke University Medical Center since 1979, where he is now Professor of Pathology, Director of the Blood Gas Laboratory, the Clinical Pediatric Laboratory, and several Outpatient Laboratories. He is also the Chief of Clinical Chemistry at the Durham VA Medical Center. He has written or presented numerous workshops, books, study guides, chapters, and seminars on the interpretation of blood gas, cooximetry, ionized calcium, magnesium, lactate (sepsis), kidney function tests (creatinine, cystatin C, GFR), and viscoelastic testing (ROTEM and TEG). His research interests include sample collection, pre-analytical errors, analysis, and clinical use of these tests.

Affiliations and Expertise

Director, Clinical Pediatric Laboratory, Duke University Medical Center, USA

Craig Rackley

Dr. Craig R. Rackley specializes in pulmonary disease in Durham, North Carolina, and has over 18 years of experience in the field of medicine. He graduated from Georgetown University of Medicine with his medical degree in 2002 and is affiliated with numerous hospitals in North Carolina, including Duke University Medical Center, USA.

Affiliations and Expertise

Assistant Professor, Duke University Medical Center, USA

Ratings and Reviews

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  • Simon B. Mon Jan 10 2022

    Expert level book

    This book is aimed at experts in the field, and shines at it! The level of detail is perfect for laboratory specialists.