Blood Clotting Enzymology

Blood Clotting Enzymology

1st Edition - January 1, 1967

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  • Editor: Walter H. Seegers
  • eBook ISBN: 9781483225456

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Blood Clotting Enzymology covers the mechanisms of blood clotting and their role in thrombosis, hemostasis, and many associated ramifications. This book is composed of 12 chapters that consider the integration of knowledge on blood clotting enzymology with hemostasis physiology. The opening chapter deals with the enzymology of the sol-gel transformation was studied in terms of proteins, fats, carbohydrates, surface physics, immunology, biophysical mechanisms, structural architecture, vitamin K and its antagonists, and the rheology of the blood. The subsequent chapters review the biophysical properties and composition of active substance in blood coagulation, as well as the concepts of prothrombin activation. These topics are followed by discussions on the chemical and physicochemical properties of fibrinogen and fibrin; the application of immulogical methods to delineate important properties of plasma constituents; and the mechanisms of antithrombin activity. Other chapters tackle the importance of hirudin and cobra venom for certain experimental laboratory work in the study of the physiology of blood coagulation. The final chapters survey the role of platelets in hemostasis, bleeding disorders, and the chemistry and function of vitamin K in blood coagulation. This book will prove useful to hematologists, enzyme scientist, immunologists, and research workers who are interested in blood coagulation mechanisms.

Table of Contents

  • List of Contributors


    Chapter 1 Use and Regulation of the Blood Clotting Mechanisms

    I. Introduction

    II. Blood Vessel Wall Dynamics

    III. Platelet Function

    IV. Autoregulation in Hemostasis

    V. Blood Coagulation

    VI. Prothrombin Activation

    VII. Complexity of Metabolic Integration

    VIII. Summary


    Chapter 2 Molecular Characteristics of Substances Active in Blood Coagulation

    I. Introduction

    II. Assay for Clotting and for Enzyme Activities

    III. Bovine Prothrombin

    IV. Human Prothrombin

    V. Prothrombin of Other Species

    VI. Bovine Thrombin

    VII. Human Thrombin

    VIII. Bovine Autoprothrombin C

    IX. Bovine Prethrombin

    X. Bovine Autoprothrombin III

    XI. Bovine Autoprothrombins Ip and Ic

    XII. Autoprothrombin II

    XIII. Fibrinogen

    XIV. Fibrin Stabilizing Factor

    XV. Hageman Factor

    XVI. Accelerator Globulin

    XVII. Platelet Cofactor I (Factor VIII)

    XVIII. Plasma Thromboplastin Antecedent

    XIX. Antithrombins

    XX. Inhibitor Source Material

    XXI. Substance P from Urine

    XXII. Factor VII, Factor IX, and Factor X

    XXIII. Platelet Factors

    XXIV. Tissue Procoagulants

    XXV. Lipid Procoagulants

    XXVI. Summary


    Chapter 3 Activation of Prothrombin

    I. Introduction

    II. Activation in Strong Salt Solutions

    III. Activation in Strong Salt Solutions: Summary

    IV. Activation of Prothrombin with Protamine Sulfate, and Polarized Surface Layers

    V. Activation Characteristics of Prethrombin and Autoprothrombin III

    VI. Formation and Significance of Intermediate Prothrombin Activation Products

    VII. Development of Fibrinogenolytic and Esterolytic Activities from Prothrombin

    VIII. Dependence of Thrombin Yield on the Limited Procoagulant or Anticoagulant

    IX. Function of Ac-Globulin and Lipids

    X. Prothrombin in Plasma

    XI. Two-stage Analysis Refractory State and Regeneration of Sensitivity to Two-stage Analytical Reagents

    XII. Summary


    Chapter 4 Fibrinogen to Fibrin Transformation

    I. Early History of the Fibrinogen-Fibrin Transformation with Emphasis on Limited Proteolysis

    II. Current Concept of the Limited Proteolysis in the Fibrinogen-Fibrin Transformation

    III. Fibrinogen and Fibrin at the Molecular Level


    Chapter 5 Immunochemistry

    I. Introduction

    II. Prothrombin and Its Derivatives

    III. Accelerator Globulin (Factor V)

    IV. Platelet Cofactor I (Factor VIII)

    V. Platelet Factor 3

    VI. Fibrinogen and Related Molecules

    VII. Conclusion


    Chapter 6 Surface Activity in Blood Coagulation

    I. Introduction

    II. Contact

    III. The Initiation of Clotting In Vivo

    IV. The Evolution of Contact Factor

    V. Summary and Certain Conclusions


    Chapter 7 Antithrombin

    I. Historical Background

    II. Methods of Measurement

    III. Preparation of Antithrombin Fractions

    IV. Action of Antithrombin

    V. Summary


    Chapter 8 Plasma Anticoagulants or Inhibitors

    I. Introduction

    II. Natural Anticoagulants

    III. Artificial Anticoagulants

    IV. Summary


    Chapter 9 Platelets in Hemostasis

    I. Description of Capillary Function in Thrombocytopenia

    II. Thrombopoietic Aspects of Platelets

    III. Platelet Functions

    IV. Metabolism of Platelets

    V. Platelet Preservation

    VI. Immunological Aspects of Platelets

    VII. Platelet Transfusion

    VIII. Summary


    Chapter 10 Irregular Blood Coagulation

    I. Introduction

    II. Inherited Bleeding Disorders

    III. Acquired Bleeding Disorders

    IV. Summary


    Chapter 11 Ultrastructure of the Fibrin Clot

    I. Introduction

    II. Specific Aims

    III. Normal Fibrin Formation

    IV. Abnormal Fibrin Formation

    V. Conclusions


    Chapter 12 Chemistry and Function of Vitamin K

    I. Introduction

    II. Chemistry of the K Vitamins

    III. Detection and Determination

    IV. Occurrence

    V. Structural Specificity of Vitamin K Action

    VI. Metabolism

    VII. Vitamin K-II (S)


    Author Index

    Subject Index

Product details

  • No. of pages: 640
  • Language: English
  • Copyright: © Academic Press 1967
  • Published: January 1, 1967
  • Imprint: Academic Press
  • eBook ISBN: 9781483225456

About the Editor

Walter H. Seegers

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