Blood Banking and Transfusion Medicine

2nd Edition

Basic Principles and Practice

Authors: Christopher Hillyer Leslie Silberstein Paul Ness Kenneth Anderson John Roback
Hardcover ISBN: 9780443069819
eBook ISBN: 9780702036255
Imprint: Churchill Livingstone
Published Date: 18th October 2006
Page Count: 912


Ever since the discovery of blood types early in the last century, transfusion medicine has evolved at a breakneck pace. This second edition of Blood Banking and Transfusion Medicine is exactly what you need to keep up. It combines scientific foundations with today's most practical approaches to the specialty. From blood collection and storage to testing and transfusing blood components, and finally cellular engineering, you'll find coverage here that's second to none. New advances in molecular genetics and the scientific mechanisms underlying the field are also covered, with an emphasis on the clinical implications for treatment. Whether you're new to the field or an old pro, this book belongs in your reference library.

Key Features

  • Integrates scientific foundations with clinical relevance to more clearly explain the science and its application to clinical practice.
  • Highlights advances in the use of blood products and new methods of disease treatment while providing the most up-to-date information on these fast-moving topics

Table of Contents

Part I. History

1. A Brief History of Blood Transfusion

Part II. Blood Banking

A. Immunohematology

i. Basic Principles

2. Principles of the Immune System Central to Transfusion Medicine
3. Principles of the Complement System Central to Transfusion Medicine
4. Principles of Red Blood Cell Allo- and Autoantibody Formation and Function

ii. Red Blood Cell, Platelet and Leukocyte Antigens and Antibodies

5. Membrane Blood Group Antigens and Antibodies
6. ABO and Related Antigens and Antibodies
7. Rh, Kell, Duffy, and Kidd Antigens and Antibodies
8. Other Blood Group Antigens and Antibodies
9. Human Platelet Antigens and Antibodies
10. HLA and Granulocyte Antigens and Antibodies

B. Blood Donation, Manufacturing, Testing and Storage

11. Blood Donation and Collection
12. Blood Manufacturing: Component Preparation, Storage and Transportation
13. Red Blood Cell Metabolism During Storage: Basic Principles and Practical Aspects
14. Infectious Disease Testing: Basic Principles and Practical Aspects

C. Regulatory, Quality and Legal Principles

15. Regulatory Principles and Issues Central to Blood Banking and Transfusion Medicine
16. Quality Assurance, Control and Improvement and Accreditation
17. Legal Principles and Issues Central to Transfusion Medicine

D. Specific Blood Components

18. Packed Red Blood Cell and Related Products
19. Fresh Frozen Plasma and Related Products
20. Cryoprecipitate and Related Products
21. Albumin
22. IVIg and Derivatives
23. Platelets and Related Products
24. Granulocytes
25. Coagulation Factor Preparations

E. Special Processes and Products

26. Leukocyte Reduced Products
27. Virus Safe Products: Pathogen Reduction and Inactivation
28. Ir


No. of pages:
© Churchill Livingstone 2007
Churchill Livingstone
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About the Author

Christopher Hillyer

Professor of Medicine, Cornell Weill Medical College, New York, NY. Dr. Hillyer also is the immediate past-president of the American Association of Blood Banking and a trustee of the National Blood Foundation (NBF). He is an associate editor of Transfusion and serves on several other editorial boards including Blood.

Affiliations and Expertise

President and CEO, New York Blood Center, New York, NY, USA

Leslie Silberstein

Affiliations and Expertise

Professor of Pathology (Pediatrics), Director, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, Massachusetts

Paul Ness

Affiliations and Expertise

Director, Transfusion Medicine Division, Johns Hopkins Medical Institutions; Professor, Pathology, Medicine, and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Kenneth Anderson

Affiliations and Expertise

Chief, Division of Hematologic Neoplasia; Director, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute; Kraft Family Professor of Medicine, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA

John Roback

Affiliations and Expertise

Associate Director, Transfusion Medicine Program; Associate Professor, Department of Pathology and Laboratory Medicine, Emory University, School of Medicine, Atlanta, GA, USA


Blood Banking and Transfusion Medicine: Basic Principles and Practice
Second Edition.
Edited by Christopher D. Hillyer, Leslie E. Silberstein, Paul M. Ness, Kenneth C. Anderson, and John D. Roback. 887 pp, ISBN-13: 978-0-443-06981-9, Philadelphia, Pa, Churchill Livingstone, Elsevier, 2007.

Substantial additions have been made in the second edition of this textbook. These are within cellular therapy, component preparation, infectious disease testing, and the basic biology of transfusion therapy. It is the editors’ goal that this textbook remains the definitive source of blood banking and transfusion medicine biology and practice for professionals within these fields.

I must admit that this second edition is an impressive textbook. In a comprehensive way it is parted into two well-balanced sections on blood banking and transfusion medicine preceded by a brief history of blood transfusion. The section on blood banking covers all relevant aspects such as immunohematology, donation, legal/regulatory (USA/Canada) issues, standard and specialized blood components including pathogen reduction and inactivation. The section on transfusion medicine is parted into chapters centered around relevant clinical settings, such as the transfusion demanding critical ill patients, patients with various kinds of coagulations defects, pediatric patients and many more. Taken together, all transfusion medical features of the transfusion demanding patients are well covered, including transfusion complications and therapeutic aphereses. Finally, a comprehensive mini section on tissue banking and cellular therapies, including stem cell transplantation, is given.

All the chapters are authored and the book edited by leading scientists who are also “operators” in the fields. Scientifically, the chapters are up to date. Obviously, a main focus has been to provide a text that is operational in relation to various practical situations and with appropriate depth of info