Bladder Cancer

Bladder Cancer

1st Edition - December 12, 2017

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  • Editor: Ja Hyeon Ku
  • eBook ISBN: 9780128099407
  • Paperback ISBN: 9780128099391

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Bladder Cancer is designed for researchers and clinicians involved in urologic practice, including urologists, medical oncologists, pathologists and radiologists. It provides comprehensive guidance for treating and understanding bladder cancer and serves as an up-to-date reference reflecting evidence-based research. The biological behavior of this disease entity shows a heterogeneous pattern with diverse morbidity and mortality depending on a variety of factors, such as tumor characteristics (tumor stage, grade, size, number, shape, and histologic subtypes) and applied treatment modalities (surgery or non-surgical management). This book presents the substantial academic developments in the field of bladder cancer in one convenient reference.

Key Features

  • Presents a comprehensive overview of the basic and translational research into bladder cancer
  • Provides the established guidelines for bladder cancer in real clinical practice and relevant evidence-based research
  • Saves academic, medical and cancer researchers time in quickly accessing the very latest details on bladder cancer, as opposed to searching through multiple sources
  • Assists academic clinicians in understanding the importance of the breakthroughs that are contributing to advances in bladder cancer research


Cancer researchers and oncologists, urologists, cell biologists, pathologists

Table of Contents

  • Chapter 1. Epidemiology, etiology, and pathophysiology
    1-1. Epidemiology
    1-2. Etiology (risk factors)
      1-2-1. Smoking
      1-2-2. Occupational exposure to chemicals
      1-2-3. Treatment related factors (radiation therapy, chemotherapy)
      1-2-4. Dietary factors
      1-2-5. Chronic urinary tract infection
      1-2-6. Gender
      1-2-7. Genetic factors
    1-3. Pathophysiology
    Chapter 2. Diagnosis
    2-1. Symptoms
    2-2. Physical examination
    2-3. Urine cytology and urinary biomarkers
    2-4. Cystoscopy
    2-5. Imaging studies
    2-6. Transurethral resection of bladder tumors (TURB)
    2-7. Bladder and prostatic urethra biopsies
    2-8. Fluorescence cystoscopy
    2-9. Second resection
    Chapter 3. Pathology and staging
    3-1. Histological classification of bladder tumors
      3-1-1. WHO classification of urothelial cell neoplasms
      3-1-2. Non-urothelial neoplasms of the bladder
    3-2. Tumor, Nodes, Metastases (TNM) classification system for bladder cancer
    Chapter 4. Treatment for non-muscle invasive bladder cancer (NMIBC)
     4-1. Risk factors for recurrence and progression
     4-2. Treatment for TaT1 tumors
     4-3. Treatment for Carcinoma in situ

     4-4. Treatment for T1G3 tumor
     4-5. Intravesical chemotherapy
       4-5-1. Single, immediate, post-operative intravesical chemotherapy
       4-5-2. Additional adjuvant intravesical chemotherapy
       4-5-3. Optimizing intravesical chemotherapy
    4-6. Intravesical BCG immunotherapy
       4-6-1. Indications for BCG
       4-6-2. Optimal BCG schedule
       4-6-3. Optimal dose of BCG
       4-6-4. BCG toxicity
    4-7. Treatment of failure of intravesical therapy
       4-7-1. Failure of intravesical chemotherapy
       4-7-2. Failure of intravesical BCG immunotherapy
    Chapter 5. Treatment for muscle-invasive bladder cancer (MIBC)
      5-1. Neoadjuvant chemotherapy
      5-2. Radical cystectomy (RC) and urinary diversion
        5-2-1. Timing of radical cystectomy
        5-2-2. Indications
        5-2-3. Open techniques and extent (including pelvic lymphadenectomy)
          5-2-4. Laparoscopic/Robot-assisted laparoscopic radical cystectomy
          5-2-3. Methods for urinary diversion (ileal conduit or orthotopic neobladder)
          5-2-4. Morbidity, mortality and survival for RC
       5-3. Bladder sparing treatments
          5-3-1. Radical TURB
          5-3-2. External beam radiotherapy
          5-3-3. Partial cystectomy
          5-3-4. Chemotherapy
          5-3-5. Multimodality treatment
       5-4. Adjuvant chemotherapy
    Chapter 6. Chemotherapy for metastatic disease
    Chapter 7. Follow-up (surveillance)
       6-1. Surveillance for NMIBC
       6-2. Surveillance for MIBC
       6-3. Novel and emerging surveillance markers for bladder cancer

Product details

  • No. of pages: 724
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: December 12, 2017
  • Imprint: Academic Press
  • eBook ISBN: 9780128099407
  • Paperback ISBN: 9780128099391

About the Editor

Ja Hyeon Ku

Dr. Ku completed his Urology training at Soonchunhyang University Hospital in South Korea. He completed fellowships at Seoul National University Hospital and subsequently obtained his Ph.D. from Seoul National University College of Medicine, Department of Urology.

He was appointed to Seoul Veterans Hospital in Korea and then moved to the Department of Urology, Seoul National Hospital. He studied bladder cancer as a Visiting Postdoc Fellow at Scott Department of Urology, Baylor College of Medicine, Houston, Texas under Dr. Seth P. Lerner. He has been a faculty member since 2007 and is now an associate professor in the Department of Urology, Seoul National University College of Medicine, Korea.

His clinical and research interests lie in urologic cancers including urothelial carcinoma. He has published more than 250 peer-reviewed journal articles and book chapters. He is also an active member of the Korean Urological Association and board member of Korean Urological Oncology Society. He has been serving on the Editorial Boards for the Korean Journal of Urology, World Research Journal of Surgical Oncology, World Journal of Clinical Oncology, and Journal of Chinese Clinical Medicine.

Affiliations and Expertise

Associate Professor, Department of Urology, Seoul National University Hospital

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