Bisphosphonates in Bone Disease

4th Edition

From the Laboratory to the Patient

Authors: Herbert Fleisch
Hardcover ISBN: 9780122603716
eBook ISBN: 9780080573908
Imprint: Academic Press
Published Date: 27th March 2000
Page Count: 212
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Description

This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs.

Key Features

  • The revised fourth edition contains approximately 50% new material
  • Includes information on all the latest drugs

Readership

Endocrinologists, oncologists.

Table of Contents

Bone and Mineral Metabolism: Bone Physiology: Morphology. Composition of bone. Modeling and remodeling. Calcium homeostasis. Bone as an organ. Assessment of bone turnover.

Bisphosphonates-Preclinical: Background to the pharmacological development: Chemistry. Actions. Physicochemical effects. Biological effects. Inhibition of bone resorption. Inhibition of mineralization.

Pharmocokinetics: Intestinal absorption. Distribution. Renal clearance. Other modes of application.

Animal toxicology: Acute toxicology. Nonacute toxicology.

Bisphosphonates-clinical: Introduction.

Paget's Disease: Definition. Epidemiology. Pathophysiology. Clinical manifestations. Treatment with drugs other than bisphosphonates. Treatment with bisphosphonates.

Osteolytic tumor-induced bone disease: Definition. Pathophysiology. Clinical manifestations. Treatment with drugs other than bisphosphonates. Treatment with bisphosphonates.

Non-tumor induced hypercalcemia: Definition. Pathophysiology. Clinical manifestations. Treatment with drugs other than bisphosphonates. Treatment with bisphosphonates.

Osteoporosis: Definition. Epidemiology. Pathophysiology. Clinical manifestations. Treatment with drugs other than bis

Details

No. of pages:
212
Language:
English
Copyright:
© Academic Press 2000
Published:
Imprint:
Academic Press
eBook ISBN:
9780080573908
Hardcover ISBN:
9780122603716

About the Author

Herbert Fleisch

Affiliations and Expertise

University of Berne, Switzerland

Reviews

This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs.