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Bipolar Disorder Vulnerability - 1st Edition - ISBN: 9780128123478, 9780128125601

Bipolar Disorder Vulnerability

1st Edition

Perspectives from Pediatric and High-Risk Populations

Editors: Jair Soares Consuelo Walss-Bass Paolo Brambilla
Paperback ISBN: 9780128123478
eBook ISBN: 9780128125601
Imprint: Academic Press
Published Date: 12th June 2018
Page Count: 288
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Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course.

Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness.

Key Features

  • Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomics
  • Examines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorder
  • Explores the interaction between genomic and environmental influences that shape behavior


Advanced students, researchers, and clinicians in biological psychiatry, psychiatry, psychology, behavioral neuroscience, and related disciplines interested in risk factors for mental illness

Table of Contents

1. Presentation and prospective course of pediatric bipolar disorder
2. The Bipolar Prodrome
3. Animal models of the bipolar prodrome
4. Polygenic risk in family members of patients with bipolar disorder
5. Gene-Environment interactions in high-risk populations
6. Influence of early childhood trauma on the prodrome of bipolar disorder
7. Neurobiological markers of stress in youth at risk for bipolar disorder
8. Neuroimaging findings in youth at risk for bipolar disorder
9. Neurocognitive findings in youth at risk for bipolar disorder
10. Neuropsychological and social cognitive function in young people at genetic risk for bipolar disorder
11. Behavioral and emotional dysregulation trajectories in symptomatic youth
12. Cognitive and neural basis of hypomania
13. Early pharmacological interventions to prevent full onset of bipolar disorder
14. Psychotherapeutic interventions
15. Summary and integration of current findings: A model for Bipolar Disorder Development


No. of pages:
© Academic Press 2018
12th June 2018
Academic Press
Paperback ISBN:
eBook ISBN:

About the Editors

Jair Soares

Jair C. Soares, MD, PhD, joined UTHealth in 2009 and currently serves as professor and Pat R. Rutherford, Jr. Chair in Psychiatry at McGovern Medical School and as executive director of UTHealth Harris County Psychiatric Center. A Board-certified psychiatrist, he also serves as chief of Psychiatry Services at Memorial Hermann Hospital and LBJ Hospital. The sites provide patient care and serve as clinical training facilities for UTHealth medical students, psychiatry residents and psychiatry fellows. Soares directs the Center of Excellence on Mood Disorders which focuses on the search for the causes and the development of new treatments for mood disorders. The center is comprised of an active research team who specializes in clinical neurosciences (neuroimaging, neurophysiology, cognitive neurosciences, and genetics), as well as clinical psychopharmacology and interventions research. After receiving his medical degree from the University of Sao Paulo in Brazil in 1990, Soares accepted a psychiatric residency in adult psychiatry at the University of Sao Paulo and a research tract residency in general psychiatry at the Western Psychiatric Institute and Clinic at the University of Pittsburgh. Subsequently, Soares received a brain imaging fellowship with the Yale University School of Medicine Department of Psychiatry. He obtained a PhD in medical sciences at the Federal University of Rio Grande do Sul in Brazil. Prior to joining UTHealth, Soares served as the Distinguished Professor of Psychiatry and Director of the Center of Excellence in Research and Treatment for Bipolar Disorders at the University of North Carolina at Chapel Hill and as Deputy Chair for Research and Division Chief for Mood and Anxiety Disorders with the Department of Psychiatry at The University of Texas Health Science Center at San Antonio. Soares has received numerous honors and awards, including the National Plaque of Honor, Republic of Panama, the Devereux Clinic Emy Award, and the “Best Doctor Award.” He published more than 200 peer-reviewed articles and book chapters in the psychiatric literature and has held editorial positions on a number of national and international medical journals. Since April 2015, he is also the co-editor in chief for the Journal of Affective Disorders.

Affiliations and Expertise

University of Texas Health Medical School, Houston, TX USA

Consuelo Walss-Bass

Dr. Walss-Bass is Associate Professor and Director of the University of Texas Health Brain Collection for Research in Psychiatric Disorders in the Department of Psychiatry and Behavioral Sciences in Houston.

Affiliations and Expertise

University of Texas Health Brain Collection for Research in Psychiatric Disorders in the Department of Psychiatry and Behavioral Sciences in Houston, TX USA

Paolo Brambilla

Dr. Brambilla is Associate Professor of Psychiatry at the University of Milan and Chair of the European Psychiatric Association (EPA) Neuroimaging Section.

Affiliations and Expertise

University of Milan, Milan Italy

Ratings and Reviews