Biotin and Other Interferences in Immunoassays

Biotin and Other Interferences in Immunoassays

A Concise Guide

1st Edition - January 15, 2019

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  • Author: Amitava Dasgupta
  • eBook ISBN: 9780128167410
  • Paperback ISBN: 9780128164297

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Biotin and Other Interferences in Immunoassays: A Concise Guide is aimed at clinical laboratory scientists, medical technologists and pathologists who are often the first individuals contacted by a clinician when a laboratory test result does not correlate with clinical presentation. Research scientists working in diagnostics companies will also find this information essential. Sources of errors in non-immunoassay based methods used in clinical chemistry and toxicology laboratory are also discussed so readers can get all important information from one concise guide. This succinct, user-friendly reference provides the necessary information to address high levels of biotin in clinical laboratory results.

Key Features

  • Discusses issues of biotin interferences and ways to avoid them for accurate clinical laboratory results
  • Provides sources of errors in non-immunoassay based methods used in clinical chemistry and toxicology laboratories
  • Highlights how to handle specimens in the lab and how to eliminate the effect of biotin in precious samples


Pathologists, clinical chemists, and toxicologists; practicing clinicians, fellows and residents in pathology, internal medicine, emergency medicine and family practice

Table of Contents

  • 1. Immunoassay design and mechanism of biotin interference
    2. Biotin: Pharmacology, Pathophysiology and Assessment of Biotin Status
    3. Biotin: From Supplement to Therapy
    4. Effect of Biotin on Clinical Laboratory Test Results: How to Avoid such Interferences?
    5. Issues of Interferences in Clinical Chemistry Tests including Heterophilic Antibody Interferences
    6. Issues of Interferences in Therapeutic Drug Monitoring
    7. Issues of Interference in Drugs of Abuse Testing and Toxicology

Product details

  • No. of pages: 144
  • Language: English
  • Copyright: © Elsevier 2019
  • Published: January 15, 2019
  • Imprint: Elsevier
  • eBook ISBN: 9780128167410
  • Paperback ISBN: 9780128164297

About the Author

Amitava Dasgupta

Amitava Dasgupta
Dr. Amitava Dasgupta received his Ph.D degree in Chemistry from Stanford University and received his medical training in Toxicology and Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School Of Medicine at Seattle. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. He is also the Director of Clinical Chemistry and Toxicology Laboratory of Memorial-Hermann Laboratory Services, the major clinical teaching hospital of the University of Texas. In addition, he is also the Medical Director of Memorial-TIRR Hospital laboratory services. Dr. Dasgupta has published over 235 scientific papers and edited, co-edited, authored or co-authored 20 books including books published by Elsevier. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis. He lectures both nationally and internationally on drug and alcohol testing and acts as an expert witness for the State of Texas for alcohol and drug related criminal prosecutions.

Affiliations and Expertise

Professor, Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas, Houston, TX, USA

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