Biothermodynamics, Part D

Biothermodynamics, Part D

1st Edition - February 16, 2011

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  • Editors: Michael Johnson, Jo Holt, Gary Ackers
  • Hardcover ISBN: 9780123860033
  • eBook ISBN: 9780123860040

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The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.

Key Features

  • Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules
  • Provides a "must-have" methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research
  • Offers step-by-step lab instructions, including necessary equipment, from a global research community


Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Table of Contents

  • 1. A Thermodynamic Approach for the Targeting of Nucleic Acid Structures Using Their Complementary Single Strands
    Hui-Ting Lee, Caroline Carr, Hollie Siebler, Lela Waters, Irine Khutsishvili, Fany Iseka, Brian Domack, Chris M. Olsen, and Luis Marky
    2. Thermodynamics of Biological Processes
    Hernan G. Garcia, Jane Kondev, Nigel Orme, Julie Theriot and Rob Phillips
    3. Protein stability in the presence of co-solutes
    Luis Marcelo F. Holthauzen, Matthew Auton, Mikhail Sineva and Jorg Rosgen
    4. Small Angle X-ray Scattering Studies of Peptide-Lipid Interactions using the Mouse Paneth Cell α-Defensin Cryptdin-4
    Abhijit Mishra, Kenneth P. Tai, Nathan W. Schmidt, André J. Ouellette and Gerard C. L. Wong
    5. Synergy of molecular dynamics and isothermal titration calorimetry in studies of allostery
    Rebecca Strawn, Thomas Stockner, Milan Melichercik, Lihua Jin, Wei-Feng Xue, Jannette Carey and Rüdiger Ettrich
    6. Using tryptophan fluorescence to measure the stability of membrane proteins folded in liposomes
    C. Preston Moon1 and Karen G. Fleming
    7. Non-B Conformations of CAG Repeats Using 2-aminopurine
    Natalya N. Degtyareva and Jeffrey T. Petty
    8. Disulfide bond-mediated passenger domain stalling as a structural probe of autotransporter outer membrane secretion in vivo
    Jonathan P. Renn & Patricia L. Clark
    9. Strategies for the Thermodynamic Characterization of Linked Binding/Local Folding Reactions Within the Native State: Application to the LID Domain of Adenylate Kinase from Escherichia coli
    Travis P. Schrank, W. Austin Elam, Jing Li and Vincent J. Hilser
    10. Fluorescence detected sedimentation in dilute and highly concentrated solutions
    Jonathan S. Kingsbury and Thomas M. Laue

Product details

  • No. of pages: 369
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: February 16, 2011
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123860033
  • eBook ISBN: 9780123860040

About the Serial Volume Editors

Michael Johnson

Affiliations and Expertise

University of Virginia Health Sciences Center, Charlottesville, USA

Jo Holt

Affiliations and Expertise

Washington University Medical Center, St. Louis, MO, USA

Gary Ackers

Affiliations and Expertise

Washington University School of Medicine, St. Louis, Mo, USA

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