Biotechnology in Healthcare, Volume 1

Biotechnology in Healthcare, Volume 1

Technologies and Innovations

1st Edition - March 30, 2022

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  • Editor: Debmalya Barh
  • eBook ISBN: 9780323898782
  • Paperback ISBN: 9780323898379

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Description

Biotechnology in Healthcare, Technologies and Innovations, Volume One presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare industry. Sections cover 3D printing, tissue engineering, synthetic biology, nano-biotechnology, omics, precision medicine, gene therapy, vaccine development, predictive healthcare, entrepreneurship, financing, business models, product development and marketing in the sector. This is a valuable source for biotechnologists, bioinformaticians, clinicians and members of biomedical and healthcare fields who need to understand more about the promising developments of the emerging field of biotechnology in healthcare.

Key Features

  • Presents the progress and innovations that biotechnology has accomplished in the field of healthcare
  • Discusses the impact of healthcare biotechnology in global economics and business prospects
  • Explains how biotechnology revolutionizes future healthcare approaches

Readership

Graduate students and researchers in biotechnology, systems biology, bioinformatics, and several members of biomedical field, clinicians, health policy makers, healthcare providers

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • List of contributors
  • About the editor
  • Preface
  • Chapter 1. Overview of healthcare biotechnology
  • Abstract
  • 1.1 Introduction
  • 1.2 Genomics
  • 1.3 Transcriptomics
  • 1.4 Proteomics
  • 1.5 Metabolomics
  • 1.6 Conclusion
  • Acknowledgments
  • References
  • Chapter 2. Three-dimensional printing in healthcare
  • Abstract
  • 2.1 Introduction
  • 2.2 Three-dimensional printing technology (hardware and software)
  • 2.3 Materials of three-dimensional printing
  • 2.4 Three-dimensional printing in surgical planning and medical education
  • 2.5 Three-dimensional printing in oral and maxillofacial surgery
  • 2.6 Three-dimensional printing in orthopedics
  • 2.7 Three-dimensional printing in neurosurgery
  • 2.8 Bioprinting tissue and organ fabrication
  • 2.9 Three-dimensional printing in pharmaceutical industry
  • 2.10 Future of three-dimensional printing
  • 2.11 Conclusion
  • References
  • Chapter 3. Synthetic biology in healthcare: technologies and applications
  • Abstract
  • 3.1 Introduction
  • 3.2 Technologies for synthetic DNA, proteins, and organisms
  • 3.3 Gen9 technology—microfluidic devices and methods for gene synthesis
  • 3.4 Transcriptional, posttranslational, and hybrid biosensing and applications
  • 3.5 Applications
  • 3.6 Synthetic biology for creating living systems to produce small molecules, for instance, aspirin, that characteristically come from chemical rather than the biological processes
  • 3.7 Living therapies—engineering microbes and bacteriophage to treat disease
  • 3.8 Future challenges and conclusions
  • Acknowledgment
  • References
  • Chapter 4. Nanotechnology in healthcare: nanoparticles for diagnostic and therapy
  • Abstract
  • 4.1 Introduction
  • 4.2 Classification and properties of nanoparticles
  • 4.3 Nanoparticle-based biosensors for medical diagnosis
  • 4.4 Nanoparticle-based therapy and imaging
  • 4.5 Conclusion and future perspective
  • References
  • Chapter 5. Analysis and applications of sequencing in healthcare
  • Abstract
  • 5.1 Introduction
  • 5.2 Method of de-novo and reference-based DNA sequencing
  • 5.3 Generation of DNA reads
  • 5.4 Quality assessment of reads
  • 5.5 Trimming of DNA reads
  • 5.6 Mapping of DNA reads
  • 5.7 Assembly
  • 5.8 Analysis of DNA sequences for marker-based surveillance of diseases
  • 5.9 Phylomedicine of genetic diseases
  • 5.10 Method of de-novo and reference-based RNA sequencing
  • 5.11 Generation of short RNA reads and quality assessment
  • 5.12 Trimming of RNA reads
  • 5.13 Mapping of RNA reads
  • 5.14 Assembly of RNA reads
  • 5.15 Analysis of differential expression of genes in diseases states and in prognosis of disease
  • 5.16 Analysis of alternative splicing of genes and gene fusion in disease states
  • 5.17 Analysis of long noncoding RNA and its relevance to disease
  • 5.18 Gene coexpression analysis and annotation of TF-TFBS and gene regulatory network
  • 5.19 Method of DAP-sequencing and genome-wide annotation of cistrome
  • 5.20 Analysis of DAP sequences and its application in healthcare
  • 5.21 Genome-wide mapping of TF-TFBS and visualization of gene-regulatory network
  • References
  • Chapter 6. Innovative technologies in precision healthcare
  • Abstract
  • 6.1 Defining precision and personalized medicine
  • 6.2 Databases applications in precision healthcare
  • 6.3 Bioengineering, machine learning for personalized medicine
  • 6.4 Application of bioinformatics machine learning and in-depth data analysis
  • 6.5 BIG DATA
  • Acknowledgments
  • References
  • Chapter 7. Omics applications in reproductive medicine
  • Abstract
  • 7.1 Genetic testing and molecular methods of female infertility
  • 7.2 Genetic testing and molecular methods of male infertility
  • 7.3 Genetic testing and molecular methods of embryonic analysis and monitoring during the in vitro fertilization process
  • 7.4 Omics methods of infertility
  • Acknowledgment
  • References
  • Chapter 8. Biotechnology approaches in developing novel drug-delivery systems
  • Abstract
  • 8.1 Introduction
  • 8.2 Drug-delivery mechanism
  • 8.3 Basic components of a drug-delivery system
  • 8.4 Different routes of a drug-delivery system
  • 8.5 Drug carriers
  • 8.6 Conclusions
  • References
  • Chapter 9. Gene therapy and gene editing in healthcare
  • Abstract
  • 9.1 Introduction: gene therapy and gene editing
  • 9.2 Gene-editing technologies
  • 9.3 Clinical trials of gene therapy and gene editing (in vivo and ex vivo): an update
  • 9.4 Gene therapy and gene editing in diseases/disorders: current progress
  • 9.5 Miscellaneous diseases and disorders
  • 9.6 Obstacles and ethical concerns
  • 9.7 Conclusions and future prospective
  • Acknowledgments
  • References
  • Chapter 10. Algae biotechnology for nutritional and pharmaceutical applications
  • Abstract
  • 10.1 Introduction
  • 10.2 Food algae feature
  • 10.3 Fermenting algae
  • 10.4 Pharmaceutical algae feature
  • 10.5 Future perspectives
  • 10.6 Conclusion
  • Acknowledgments
  • References
  • Chapter 11. Phage therapy: a promising approach to counter antimicrobial drug resistance
  • Abstract
  • 11.1 Overview of antimicrobial drug resistance
  • 11.2 Phage therapy to counter antibacterial resistance
  • 11.3 Phages against antimicrobial resistance—an alternative strategy
  • 11.4 Mode of action of phage
  • 11.5 Journey of phage therapy
  • 11.6 Different approaches for phage therapy
  • 11.7 Strategies and recent advances in phage therapy
  • 11.8 Options for the administration of phage therapy
  • 11.9 Real-time use of phage therapy
  • 11.10 Upside and flipside of phage therapy
  • 11.11 Regulatory requirements
  • 11.12 Outstanding challenges in phage therapy
  • 11.13 Conclusion and future directions
  • Acknowledgment
  • References
  • Chapter 12. Biotechnology strategies for the development of novel therapeutics and vaccines against the novel COVID-19 pandemic
  • Abstract
  • 12.1 Antiviral COVID-19 drugs
  • 12.2 Monoclonal antibodies against COVID-19
  • 12.3 Vaccines against COVID-19
  • 12.4 Conclusion
  • References
  • Chapter 13. Applications of microbial omics in healthcare
  • Abstract
  • 13.1 Introduction to microbial omics
  • 13.2 Phylogenomics: inferring evolutionary relationships between microorganisms
  • 13.3 Metagenomics: concepts in reconstructing genomes from metagenomes
  • 13.4 Applications of microbial omics in diagnosis
  • 13.5 Pan-genomics: comparative genomics in the era of omics data explosion
  • 13.6 Therapeutic approaches employing microbial genomes and proteomes
  • 13.7 Conclusion
  • 13.8 Future prospects
  • References
  • Chapter 14. Artificial intelligence applied to healthcare and biotechnology
  • Abstract
  • 14.1 Introduction
  • 14.2 Data analytics
  • 14.3 Algorithms used in artificial intelligence applications
  • 14.4 Supervised and unsupervised classification methods
  • 14.5 Machine learning and deep learning
  • 14.6 Steps needed during the application of artificial intelligence
  • 14.7 Analysis and interpretation of the data
  • 14.8 The need for validation
  • 14.9 Outliers, overfitting, and underfitting
  • 14.10 Interpretation
  • 14.11 The significance of the multidisciplinary approach
  • 14.12 Conclusion and future directions
  • References
  • Chapter 15. Intellectual property rights in healthcare: an overview
  • Abstract
  • 15.1 Introduction
  • 15.2 Intellectual properties
  • 15.3 Rights protected under intellectual property laws
  • 15.4 Intellectual property right in healthcare
  • 15.5 Chemical products and pharmaceutical drugs
  • 15.6 Healthcare information technology
  • 15.7 Gene patents and personalized medicines
  • 15.8 Indian patent advanced search system
  • 15.9 Indian pharmaceutical industries and scope of patents
  • 15.10 Patent licensing and transfer of rights
  • 15.11 Conclusion
  • References
  • Index

Product details

  • No. of pages: 290
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: March 30, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323898782
  • Paperback ISBN: 9780323898379

About the Editor

Debmalya Barh

Debmalya Barh
Debmalya Barh, PhD, holds Master’s and PhD’s degree on Biotechnology and Post-Doc on Bioinformatics. He is honorary Principal Scientist at Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology, a global platform of multidisciplinary research and advocacy. He has experience with both academic and industrial research and has more than 12 years on bioinformatics and personalized diagnostic/medicine industry experience, with focus on translating academic research into high value commercial products. He has published more than 150 articles in reputed international journals and has edited 15 cutting-edge biotechnology related reference books. He has also co-authored 30+ book chapters. Due to his significant contribution in the field, he has been recognized by Who's Who in the World and Limca Book of Records.

Affiliations and Expertise

Principal Scientist, Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology, Nonakuri, Purba Medinipur, West Bengal, India

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