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Biotechnology in Healthcare, Volume 1
Technologies and Innovations
1st Edition - March 30, 2022
Editor: Debmalya Barh
Language: English
Paperback ISBN:9780323898379
9 7 8 - 0 - 3 2 3 - 8 9 8 3 7 - 9
eBook ISBN:9780323898782
9 7 8 - 0 - 3 2 3 - 8 9 8 7 8 - 2
Biotechnology in Healthcare, Technologies and Innovations, Volume One presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare indust…Read more
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Biotechnology in Healthcare, Technologies and Innovations, Volume One presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare industry. Sections cover 3D printing, tissue engineering, synthetic biology, nano-biotechnology, omics, precision medicine, gene therapy, vaccine development, predictive healthcare, entrepreneurship, financing, business models, product development and marketing in the sector. This is a valuable source for biotechnologists, bioinformaticians, clinicians and members of biomedical and healthcare fields who need to understand more about the promising developments of the emerging field of biotechnology in healthcare.
Presents the progress and innovations that biotechnology has accomplished in the field of healthcare
Discusses the impact of healthcare biotechnology in global economics and business prospects
Explains how biotechnology revolutionizes future healthcare approaches
Graduate students and researchers in biotechnology, systems biology, bioinformatics, and several members of biomedical field, clinicians, health policy makers, healthcare providers
Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
About the editor
Preface
Chapter 1. Overview of healthcare biotechnology
Abstract
1.1 Introduction
1.2 Genomics
1.3 Transcriptomics
1.4 Proteomics
1.5 Metabolomics
1.6 Conclusion
Acknowledgments
References
Chapter 2. Three-dimensional printing in healthcare
Abstract
2.1 Introduction
2.2 Three-dimensional printing technology (hardware and software)
2.3 Materials of three-dimensional printing
2.4 Three-dimensional printing in surgical planning and medical education
2.5 Three-dimensional printing in oral and maxillofacial surgery
2.6 Three-dimensional printing in orthopedics
2.7 Three-dimensional printing in neurosurgery
2.8 Bioprinting tissue and organ fabrication
2.9 Three-dimensional printing in pharmaceutical industry
2.10 Future of three-dimensional printing
2.11 Conclusion
References
Chapter 3. Synthetic biology in healthcare: technologies and applications
Abstract
3.1 Introduction
3.2 Technologies for synthetic DNA, proteins, and organisms
3.3 Gen9 technology—microfluidic devices and methods for gene synthesis
3.4 Transcriptional, posttranslational, and hybrid biosensing and applications
3.5 Applications
3.6 Synthetic biology for creating living systems to produce small molecules, for instance, aspirin, that characteristically come from chemical rather than the biological processes
3.7 Living therapies—engineering microbes and bacteriophage to treat disease
3.8 Future challenges and conclusions
Acknowledgment
References
Chapter 4. Nanotechnology in healthcare: nanoparticles for diagnostic and therapy
Abstract
4.1 Introduction
4.2 Classification and properties of nanoparticles
4.3 Nanoparticle-based biosensors for medical diagnosis
4.4 Nanoparticle-based therapy and imaging
4.5 Conclusion and future perspective
References
Chapter 5. Analysis and applications of sequencing in healthcare
Abstract
5.1 Introduction
5.2 Method of de-novo and reference-based DNA sequencing
5.3 Generation of DNA reads
5.4 Quality assessment of reads
5.5 Trimming of DNA reads
5.6 Mapping of DNA reads
5.7 Assembly
5.8 Analysis of DNA sequences for marker-based surveillance of diseases
5.9 Phylomedicine of genetic diseases
5.10 Method of de-novo and reference-based RNA sequencing
5.11 Generation of short RNA reads and quality assessment
5.12 Trimming of RNA reads
5.13 Mapping of RNA reads
5.14 Assembly of RNA reads
5.15 Analysis of differential expression of genes in diseases states and in prognosis of disease
5.16 Analysis of alternative splicing of genes and gene fusion in disease states
5.17 Analysis of long noncoding RNA and its relevance to disease
5.18 Gene coexpression analysis and annotation of TF-TFBS and gene regulatory network
5.19 Method of DAP-sequencing and genome-wide annotation of cistrome
5.20 Analysis of DAP sequences and its application in healthcare
5.21 Genome-wide mapping of TF-TFBS and visualization of gene-regulatory network
References
Chapter 6. Innovative technologies in precision healthcare
Abstract
6.1 Defining precision and personalized medicine
6.2 Databases applications in precision healthcare
6.3 Bioengineering, machine learning for personalized medicine
6.4 Application of bioinformatics machine learning and in-depth data analysis
6.5 BIG DATA
Acknowledgments
References
Chapter 7. Omics applications in reproductive medicine
Abstract
7.1 Genetic testing and molecular methods of female infertility
7.2 Genetic testing and molecular methods of male infertility
7.3 Genetic testing and molecular methods of embryonic analysis and monitoring during the in vitro fertilization process
7.4 Omics methods of infertility
Acknowledgment
References
Chapter 8. Biotechnology approaches in developing novel drug-delivery systems
Abstract
8.1 Introduction
8.2 Drug-delivery mechanism
8.3 Basic components of a drug-delivery system
8.4 Different routes of a drug-delivery system
8.5 Drug carriers
8.6 Conclusions
References
Chapter 9. Gene therapy and gene editing in healthcare
Abstract
9.1 Introduction: gene therapy and gene editing
9.2 Gene-editing technologies
9.3 Clinical trials of gene therapy and gene editing (in vivo and ex vivo): an update
9.4 Gene therapy and gene editing in diseases/disorders: current progress
9.5 Miscellaneous diseases and disorders
9.6 Obstacles and ethical concerns
9.7 Conclusions and future prospective
Acknowledgments
References
Chapter 10. Algae biotechnology for nutritional and pharmaceutical applications
Abstract
10.1 Introduction
10.2 Food algae feature
10.3 Fermenting algae
10.4 Pharmaceutical algae feature
10.5 Future perspectives
10.6 Conclusion
Acknowledgments
References
Chapter 11. Phage therapy: a promising approach to counter antimicrobial drug resistance
Abstract
11.1 Overview of antimicrobial drug resistance
11.2 Phage therapy to counter antibacterial resistance
11.3 Phages against antimicrobial resistance—an alternative strategy
11.4 Mode of action of phage
11.5 Journey of phage therapy
11.6 Different approaches for phage therapy
11.7 Strategies and recent advances in phage therapy
11.8 Options for the administration of phage therapy
11.9 Real-time use of phage therapy
11.10 Upside and flipside of phage therapy
11.11 Regulatory requirements
11.12 Outstanding challenges in phage therapy
11.13 Conclusion and future directions
Acknowledgment
References
Chapter 12. Biotechnology strategies for the development of novel therapeutics and vaccines against the novel COVID-19 pandemic
Abstract
12.1 Antiviral COVID-19 drugs
12.2 Monoclonal antibodies against COVID-19
12.3 Vaccines against COVID-19
12.4 Conclusion
References
Chapter 13. Applications of microbial omics in healthcare
Abstract
13.1 Introduction to microbial omics
13.2 Phylogenomics: inferring evolutionary relationships between microorganisms
13.3 Metagenomics: concepts in reconstructing genomes from metagenomes
13.4 Applications of microbial omics in diagnosis
13.5 Pan-genomics: comparative genomics in the era of omics data explosion
13.6 Therapeutic approaches employing microbial genomes and proteomes
13.7 Conclusion
13.8 Future prospects
References
Chapter 14. Artificial intelligence applied to healthcare and biotechnology
Abstract
14.1 Introduction
14.2 Data analytics
14.3 Algorithms used in artificial intelligence applications
14.4 Supervised and unsupervised classification methods
14.5 Machine learning and deep learning
14.6 Steps needed during the application of artificial intelligence
14.7 Analysis and interpretation of the data
14.8 The need for validation
14.9 Outliers, overfitting, and underfitting
14.10 Interpretation
14.11 The significance of the multidisciplinary approach
14.12 Conclusion and future directions
References
Chapter 15. Intellectual property rights in healthcare: an overview
Abstract
15.1 Introduction
15.2 Intellectual properties
15.3 Rights protected under intellectual property laws
15.4 Intellectual property right in healthcare
15.5 Chemical products and pharmaceutical drugs
15.6 Healthcare information technology
15.7 Gene patents and personalized medicines
15.8 Indian patent advanced search system
15.9 Indian pharmaceutical industries and scope of patents
15.10 Patent licensing and transfer of rights
15.11 Conclusion
References
Index
No. of pages: 290
Language: English
Edition: 1
Published: March 30, 2022
Imprint: Academic Press
Paperback ISBN: 9780323898379
eBook ISBN: 9780323898782
DB
Debmalya Barh
Dr. Debmalya Barh is currently a Visiting Full Professor (Titular, Grade-E) in Bioinformatics and Precision Health at the Department of Genetics, Ecology, and Evolution, ICB, Federal University of Minas Gerais, Brazil and honorary scientist of the Institute of Integrative Omics and Applied Biotechnology (IIOAB), India. With over 20 years of experience, he has led academic, healthcare, molecular diagnostic, and bioinformatics industry endeavors. He works with more than 400 scientists from 100+ top ranked organizations across 40+ countries and has 220+ publications and a branded editor for 10+ cutting-edge omics related reference books. He is an expert in in precision/personalized health and integrative omics-based biomarker and target discovery in infectious and complex lifestyle diseases.
Affiliations and expertise
Federal University of Minas Gerais, Belo Horizonte, Brazil
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