Table of Contents
- The biosynthesis of 5-aminolaevulinic acid and its transformation into uroporphyrinogen III (P.M. Jordan). Early isotopic studies on the origin of the tetrapyrrole ring. The biosynthesis of 5-aminolaevulinic acid from glycine. The biosynthesis of 5-aminolaevulinic acid from glutamate. The biosynthesis of porphobilinogen. The biosynthesis of uroporphyrinogen III. Mechanism and stereochemistry of the enzymes involved in the conversion of uroporphyrinogen III into haem (M. Akhtar). Uroporphyrinogen decarboxylase [uroporphyrinogen carboxylase]. Coproporphyrinogen oxidase. Protoporphyrinogen IX oxidase. Ferrochelatase. The biosynthesis of vitamin B12 (A.I. Scott and P.J. Santander). The carbon balance. Stereochemistry of methyl group insertion in corrinoid biosynthesis. Concerning the fate of the methyl group protons. Uro'gen III is a precursor of vitamin B12. Characterization and intermediacy of the isobacteriochlorins of P.shermanii. The methylation sequence: pulse experiments. Timing of the decarboxylation step. The protein balance of vitamin B12 biosynthesis. Factors S1-S4, isomeric, tetramethylated corphinoids derived from uro'gen I. The methyl transferases. Biosynthesis of the neucleotide loop and coenzyme B12. Evolutionary aspects of B12 biosynthesis. Biochemistry of coenzyme F430, a nickel porphinoid involved in methanogenesis (H.C. Friedman, A. Klein and R.K. Thauer). Structural relations to other tetrapyrroles. Biosynthesis from glutamate via uroporphyrinogen III and dihydrosirohydrochlorin. Properties of free coenzyme F430 including its redox behaviour. Function of coenzyme F430 as prosthetic group of methyl coenzyme M reductase in methanogenesis. Comparative analysis of genes encoding methyl coenzyme M reductase. Biochemistry and regulation of photosynthetic pigment
formation in plants and algae (S.I. Beale and J.D. Weinstein). The variety and functions of plant and algal tetrapyrroles. The biosynthetic route. Regulation. The structure and biosynthesis of bacteriochlorophylls (K.M. Smith). Nomenclature. Occurrence and structures. Biosynthesis. The genes of tetrapyrrole biosynthesis (P.M. Jordan and I.A. Mgbeje). Genes of
haem biosynthesis. Genes of cobalamin (B12) biosynthesis. Genes of bacteriochlorophyll and chlorophyll biosynthesis.
- No. of pages: 308
- Language: English
- Copyright: © Elsevier Science 1991
- Published: November 21, 1991
- Imprint: Elsevier Science
- eBook ISBN: 9780080860794
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