Biosynthesis of Antibiotics

Biosynthesis of Antibiotics

1st Edition - January 1, 1966

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  • Editor: J Snell
  • eBook ISBN: 9780323159197

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Biosynthesis of Antibiotics, Volume I focuses on research conducted on the properties, compositions, and chemical reactions of antibiotics. Composed of contributions of authors, the book discusses the microbial processes for the preparation of radioactive antibiotics. Areas of discussions include an introduction; microbial methods used in the preparation of radioactive antibiotics; and the presence of radioactive antibiotics prepared through microbial processes. The volume also focuses on the biosynthesis of penicillin and cephalosporins. Areas of interest include biosynthesis of penicillins; penicillin acylases; and cephalosporin C biosynthesis. The text also provides information on the biosynthesis of tetracycline antibiotics, streptomycin, and macrolide antibiotics. Numerical representations and schematic diagrams are presented to show the properties, compositions, and chemical reactions of antibiotics when exposed to varying conditions. This volume is a great source of data for workers, graduate students, and faculties of biological sciences in the conduct of academic and industrial research.

Table of Contents

  • List of Contributors


    1. Microbial Processes for the Preparation of Radioactive Antibiotics

    I. Introduction

    II. Microbial Methods Used in the Preparation of Radioactive Antibiotics

    III. Some Radioactive Antibiotics Prepared by Microbial Processes

    IV. Summary


    2. Biosynthesis of Penicillins and Cephalosporins

    I. Introduction

    II. Biosynthesis of Penicillins by Penicillium

    III. Penicillin Acylases

    IV. New Penicillins

    V. Penicillin Ν Biosynthesis by Cephalosporium and Emericellopsis

    VI. Cephalosporin C Biosynthesis by Cephalosporium

    VII. Derivatives of Cephalosporin C (New Cephalosporins)

    VIII. Enzymes Which Act on Cephalosporin C

    IX. Hypothetical Pathway of Cephalosporin C and Penicillin Biosynthesis

    X. Summary


    3. Biosynthesis of Tetracycline Antibiotics

    I. Introduction

    II. General Considerations

    III. Origin of Carbon Atoms in the Tetracycline Molecule

    IV. Mechanisms and Intermediates

    V. Cell-Free Systems

    VI. Summary


    4. Biosynthesis of Streptomycin

    I. Introduction

    II. Biosynthesis of Streptidine

    III. Biosynthesis of 2-Deoxy-2-methylamino-L-glucose

    IV. Biosynthesis of Streptose

    V. Transglycosylation Reactions in the Formation of Streptomycin


    5. Biosynthesis of Polyacetylenes in Fungi

    I. Introduction

    II. Precursor Units

    III. Origin of Triple Bonds

    IV. Dynamics of Polyacetylene Synthesis

    V. Prospects


    6. Biochemistry of the Macrolide Antibiotics

    I. Introduction

    II. Structural Variation within the Macrolide Group

    III. Mechanisms Implicated in Macrolide Biogenesis

    IV. Sources of the Macrolide Precursors

    V. Biological Role of the Macrolides


    Author Index

    Subject Index

Product details

  • No. of pages: 246
  • Language: English
  • Copyright: © Academic Press 1966
  • Published: January 1, 1966
  • Imprint: Academic Press
  • eBook ISBN: 9780323159197

About the Editor

J Snell

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