Biosynthesis, Modification, and Processing of Cellular and Viral Polyproteins

Biosynthesis, Modification, and Processing of Cellular and Viral Polyproteins presents the proceedings of the international conference held in Hamburg-Blankenese on May 27-31, 1980. The book discusses topics on polyproteins, polyfunctional proteins, precursor proteins, as well as the differences in synthesis and processing of ACTH/endorphin peptides in primary cultures of anterior and intermediate lobes of the pituitary. The text also presents evidence for a self-cleaving precursor of virus-coded protease, RNA-replicase, and VPg; and the role of Pr180gag-pol in the characterization and genetic analysis of retrovirus maturation.

Contributors

Foreword

Preface

Opening Remarks

Polyproteins-Polyfunctional Proteins-Precursor Proteins

I. Biosynthesis of Precursors

Neuropolypeptides Illustrate a New Perspective in Mammalian Protein Synthesis—The Composite Common Precursor

A. Hypothalamic Precursors

Biosynthetic Precursors of Neurohormones: High Molecular Weight Immunoreactive Forms of Neurophysin:Vasopressin and of Somatostatin

On the Biosynthetic Origin of Neurophysin-Neurohypophyseal Peptide Hormone Complexes

Hypothalamic mRNA-Directed Synthesis of Neuropolypeptides: Immunological Identification of Precursors to Neurophysin II/Arginine Vasopressin and to Neurophysin I/Oxytocin

Efforts Directed Toward an Understanding of the Biosynthesis of the Hypothalamic-Releasing Hormones

Immunological, Enzymological, and Chemical Characterization of a Large Somatostatin-Like Polypeptide

B. Pituitary Precursors

Pro-Opiomelanocortin: A New Concept Issued from ACTH and LPH Biosynthetic Studies

Biosynthesis of the Enkephalins: Precursors and Intermediates

C. Viral Precursors

Synthesis and Maturation of the Vesicular Stomatitis Virus Glycoprotein

II. Processing and Modifications

Differences in Synthesis and Processing of ACTH/Endorphin Peptides in Primary Cultures of Anterior and Intermediate Lobes of the Pituitary

Post-Translational Processing of Pro-ACTH/Endorphin in Rat Pituitary

The Role of the Carbohydrate in the Stabilization, Processing, and Packaging of Pro-ACTH/αMSH-Endorphin in Frog and Mouse Pituitary Neurointermediate Lobes

Polyadenylylation of Reovirus Proteins

Processing of the Influenza Virus Hemagglutinin

Alte