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Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient’s life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology.
Biosensor Based Advanced Cancer Diagnostics helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems.
- Covers design and development of advanced platforms for rapid diagnosis of cancerous biomarkers
- Takes a multidisciplinary approach to sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical systems, and device packaging for point-of-care applications
- Offers an insight into how to develop cost-effective diagnostics for early detection of cancer
Biomedical engineers, computer scientists, electronic engineers. Clinicians, oncologists, pathologists, molecular biologists, medical practitioners, analytical chemists and academic institutes etc for development of novel diagnostic technologies
1. Introduction: background, state-of-art for design and development of biosensor-based techniques strategy
2. Types of Biomarkers associated with cancer and other disease associated health risk factors
(a) Protein Biomarkers
(b) Transcriptome Biomarkers
(c) Genomic Biomarkers
(d) Metabolomic Biomarkers
(e) Microbiota Biomarkers
3. Basic concept for Biosensor based devices
(a) Point of Care
(b) Microfluidic System
(b) Miniaturized total analysis systems
(c) Emerging Disease
4. Type of Biosensors based on Biorecognition element
(a) Antibody based
(b) Enzyme Based
(c) Aptamer Based
5. Type of Biosensors based on transducers
(h) Fluorescence Based
6. Multidisciplinary approach to device design
(a) Sensitive transducers development
(b) Miniaturized analytical system
(c) Microfluidic Device with Integrated Biosensors
(d) Device packaging for point-of-care application
7. Fabrication technique of Biosensor-devices
(a) 3D Printed Microfluidic Device
(b) Membrane strip biosensor system for point-of-care testing
(c) Paper-based microfluidic devices
(d) Microchip-based immunomagnetic detection
8. Lab-on-chip devices-based type of cancer cell targeting
(a) Biosensor based for cancer cell detection
(b) Microfluidic platforms for biomarker
(c) Lab-on-Chip Prototype for the Detection
(d) The future of microfluidics for biomarker detection
9. Challenges and future prospects and commercial viability of Biosensor-based diagnosis
- No. of pages:
- © Academic Press 2021
- 1st September 2021
- Academic Press
- Paperback ISBN:
Raju Khan is currently working as Principal Scientist & Associate Professor at Microfluidics & MEMS Centre, CSIR-Advanced Materials and Processes Research Institute (AMPRI), Bhopal, India. His current research is on electrochemical point-of-care diagnostics, nanostructure materials based electrochemical biosensor devices integrated with microfluidics for clinical applications, food analysis and antimicrobial applications. Dr Khan is also working on SARS-CoV-2 diagnostics project funded by DST-SERB. He has completed several National & International collaborative projects, Indo-Czech Republic & Indo-Russia etc. He awarded the reputed BOYSCAST fellowship from DST Govt of India and worked as a visiting scientist for one year at UTSA, USA. Since then, Dr. Khan is continuously very productive along with more than 15 years R&D and teaching experiences with producing high quality research, mentoring students, and supporting analytical & microfluidics division as outsource facility. His research is highly interdisciplinary and overlaps with Material Science, Biochemistry, Microbiology, Biotechnology and Analytical Chemistry.
Principal Scientist & Associate Professor, Microfluidics & MEMS Centre, CSIR-Advanced Materials and Processes Research Institute (AMPRI), India.
Arpana Parihar is currently working as Scientist under the DST WoS B scheme, at Microfluidics & MEMS Centre, CSIR-AMPRI, Bhopal, India. She did her PhD from Raja Rammana Centre for Advanced technology, Indore under the ages of HBNI, Mumbai. Her doctoral research work involves evaluation of tumor selectivity and photodynamic therapy (PDT) efficacy of Chlorin p6 through receptor mediated targeted delivery. After her PhD, she worked as a post-doctoral researcher at CBME, IIT Delhi. At IITD her research work was to enhance the osteoinductive and osteoconductive properties of various implants made up of metals, ceramic and polymers. Dr. Parihar is awarded with GATE, CSIR-NET, DST-WoS A and WoS B fellowship. She has more than 6 years of research and teaching experience at various prestigious institutes. Her current research interest includes Fabrication of biosensor for early diagnosis of cancer, Docking and simulation, Tissue engineering, Targeted Cancer therapy, 3D cell culture.
DST Women Scientist B, Microfluidics & MEMS Centre, CSIR-Advanced Materials and Processes Research Institute (AMPRI), India.
Sunil Kumar Sanghi was working as Chief Scientist, Professor and head at Microfluidics & MEMS Centre, CSIR-Advanced Materials and Processes Research Institute, Bhopal, India. His past research areas were development of manual and automated procedures for all kinds of analytes in biomedical, pharmaceutical and environmental samples using micro liquid, capillary gas chromatographic and capillary electrophoretic separation techniques in combination with sample preparation, derivatization and reaction-detection systems, micro-chip-based separation under the concept of lab-on-a-chip. Dr. Sanghi has successfully completed several International and national collaborative R & D projects viz. Indo- European Union, Indo – French, NMITLI etc. He was awarded the reputed Marie Curie Fellowship of European Union, and worked as a visiting scientist for three years at the University of Amsterdam and Institute Curie, Paris. He holds an experience of 35 years in R&D and teaching. Recently, Dr. Sanghi has received the National Meritorious Innovation Award 2021 from Government of India.
Chief Scientist & Head, Microfluidics & MEMS Centre & Materials for Radiation Shielding and Cement free Concrete CSIR-Advanced Materials and Processes Research Institute (AMPRI), India.
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