The second edition of Bioscience and Bioengineering of Titanium Materials is an essential resource for anyone researching titanium in its fundamental aspects and in medical/dental applications. The book organizes and processes the findings from over 2,000 published articles and studies into a coherent and easily accessible volume, deftly weaving together older and newer technologies to give a clear overview. Bridging the gap between medical/dental and engineering/technology areas, the book covers material classification, fabrication and modification, as well as applications and biological reactions to titanium implants.

The author, with extensive work in academics and industry, helps medical practitioners and students answer many practical questions, including: What is titanium? What type of titanium materials should I use in this case? How can I fabricate my design using titanium? Are there any alternative materials or methods? In the second edition, macro-, micro-, and nano-texturing of titanium surfaces, tissue engineering-related materials including scaffolds, and functionally graded materials and structures are extensively included and analyzed.

Key Features

  • Provides quick access to the primary literature in this field
  • Up-to-date information on nanoscience and nanotechnology developments
  • Helps answer questions about the most appropriate materials to use and when to use them


Materials scientists, students, and engineers working in biomaterials research and applications.

Table of Contents



Preface for the Second Edition

1. Introduction


2. Materials Classification

2.1. Introduction

2.2. General Classification

2.3. Medical/Dental Titanium Materials


3. Chemical and Electrochemical Reactions

3.1. Introduction

3.2. Discoloration

3.3. Corrosion in Media Containing Fluorine Ion and Bleaching Agents

3.4. Corrosion under Influences of Environmental and Mechanical Actions

3.5. Metal Ion Release and Dissolution

3.6. Galvanic Corrosion

3.7. Microbiology-Induced Corrosion

3.8. Reaction with Hydrogen


4. Oxidation and Oxides

4.1. Introduction

4.2. Formation of Titanium Oxides

4.3. Influences on Biological Processes

4.4. Crystal Structures of Titanium Oxides

4.5. Characterization of Oxides

4.6. Unique Applications of Titanium Oxide

4.7. Oxide Growth, Stability, and Breakdown

4.8. Reaction with Hydrogen Peroxide

4.9. Applications of Advanced Technologies


5. Mechanical and Tribological Behaviors

5.1. Introduction

5.2. Fatigue

5.3. Fretting

5.4. Fracture and Fracture Toughness

5.5. Biotribological Actions

5.6. Improvement for Antitribological Deterioration


6. Biological Reactions

6.1. Introduction

6.2. Toxicity

6.3. Cytocompatibility (Toxicity to Cells)

6.4. Allergic Reaction

6.5. Metabolism

6.6. Biocompatibility

6.7. Biomechanical Compatibility


7. Implant-Related Biological Reactions

7.1. Introduction

7.2. Bone Healing

7.3. Bone Grafting

7.4. Hemocompatibility

7.5. Cell Adhesion, Adsorption, Spreading, and Proliferation

7.6. Roughness and Cellular Response t


No. of pages:
© 2013
eBook ISBN:
Print ISBN:
Print ISBN:

About the author

Yoshiki Oshida

Affiliations and Expertise

Professor Emeritus, School of Dentistry, Indiana University, Bloomington, IN, USA Research Professor, College of Engineering, Syracuse University, Syracuse, NY, USA Adjunct Professor, School of Dentistry, University of California San Francisco, San Francisco, CA, USA


"Oshida…reviews published research in engineering and in medicine and dentistry, notes differences and similarities, and fills in the gaps when possible based on his 20 years of experience in each field…topics are chemical and electrochemical reactions; oxidation and oxides; mechanical and tribological behaviors; biological reactions; implant-related biological reactions; implant applications; other applications; fabrication technologies; surface modifications; and advanced materials, technologies, and processes."--Reference & Research Book News, December 2013