Bioreactor Modeling

Bioreactor Modeling

Interactions between Hydrodynamics and Biology

1st Edition - September 29, 2017

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  • Author: Jerome Morchain
  • Hardcover ISBN: 9781785481161
  • eBook ISBN: 9780081011669

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Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors.By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena.

Key Features

  • Presents a multiphase description of bioreactor modeling
  • Includes a combination of concepts issued from different scientific fields to address a practical issue
  • Provides a detailed description of the population balance concept as applied to biological systems
  • Covers a set of illustrative examples of the interaction between hydrodynamics and biological response


Graduate, postgraduate and researchers in Bioprocess Engineering

Table of Contents

  • 1. Basic Concepts for Bioreactor Modelling
    2. Mixing, Transfer and Reaction
    3. Flow Characterization and Particle Trajectory
    4. From Average Cell to Population Balance Approach
    5. Mechanical Interactions

Product details

  • No. of pages: 218
  • Language: English
  • Copyright: © ISTE Press - Elsevier 2017
  • Published: September 29, 2017
  • Imprint: ISTE Press - Elsevier
  • Hardcover ISBN: 9781785481161
  • eBook ISBN: 9780081011669

About the Author

Jerome Morchain

Jérôme Morchain has been a process engineer and a lecturer at INSA Toulouse in France since 2003. He conducts research on the modeling of biological reactors at the Biosystems and Process Engineering Laboratory (LISBP).

Affiliations and Expertise

INSA, France

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