Bioreactor Design Fundamentals - 1st Edition - ISBN: 9780750691079, 9781483221083

Bioreactor Design Fundamentals

1st Edition

Authors: Norton G. McDuffie
eBook ISBN: 9781483221083
Imprint: Butterworth-Heinemann
Published Date: 8th October 1991
Page Count: 150
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Bioreactor Design Fundamentals presents the development in the bioreactor field. This book discusses the applications of biological kinetics and thermodynamics.

Organized into seven chapters, this book begins with an overview of the design of biological reactors that involves determining operating conditions, sizing the reactor, controlling temperature and sterility, and controlling operating variables. This text then examines the significance of pH considerations in biological reactor and process design. Other chapters consider enzyme kinetics and the equations most commonly used as models for overall enzyme kinetics. This book discusses as well the mass transfer rates in bioreactors, which are significant because of their effects on some chemical reaction rates in transformations by enzymes or by living cells. The final chapter deals with the ideal state of the continuous stirred-tank reactors (CSTRs).

This book is a valuable resource for biochemical engineers and industrial microbiologists.

Table of Contents


1 Introduction

2 Thermodynamics and Stoichiometry for Bioreactor Design


Standard States

pH and Buffers


Energy Balances

Phase Equilibrium Relationships

Reaction Equilibrium

3 Enzyme Kinetics

Mathematical Models for Enzyme-Catalyzed Reactions

Effect of Temperature on Enzymatic Reactions

Effect of pH on Enzyme-Catalyzed Reactions

Enzyme Inhibition

Types of Inhibitors

Reversibility of Inhibition

Time-Dependent Deactivation

Equilibrium Inhibition Models for Michaelis-Menten Kinetics

Kinetics of Polymer Hydrolysis

4 Mass-Transfer Fundamentals

Mass-Transfer Limitations

Intraphase Mass Transfer

Gas-Liquid Mass Transfer

Mass Transfer Through Membranes

Mass Transfer Through Porous Structures

Interphase Mass Transfer at Liquid-Liquid Interfaces

Mass Transfer at Solid-Liquid Interfaces

General Mass-Transfer Considerations

5 Kinetics of Cellular Multiplication

Nature of Cell Growth and Multiplication

Monod Kinetics

Stoichiometry for Substrate and Product Relationships

Alternative Mathematical Models

Temperature Effects on Cell Processes

Effects of Other Environmental Factors

Cell Growth Inhibition

Mass-Transport and Physical Restraint Limitations

Mixed Cultures

Autotrophic Growth

Rate Limit Determinations

6 Enzyme Reactors


Nonimmobilized Enzyme Systems

Immobilized Enzyme Systems

Stirred-Tank Bioreactors

Plug-Flow Bioreactors

Comparison of Plug-Flow and CSTR Reactors

Reactor Combinations

7 Cell Culture Bioreactors

Types of Biological Growth Reactors

CSTR Biological Growth Systems

The Batch Stirred-Tank Culture System

Fed-Batch Cultures

Single Continuous-Flow CSTR without Recycle

Graphic Analysis of Single and Multiple CSTRs

Plug-Flow Reactors for Cell Growth

Recycle Operations

Continuous Culture of Photosynthetic Organisms

Sterilization of Culture Media

Scale-Up of Cell-Culture Bioreactors

List of Symbols




No. of pages:
© Butterworth-Heinemann 1991
eBook ISBN:

About the Author

Norton G. McDuffie

Ratings and Reviews