Bioreactor Design Fundamentals

Bioreactor Design Fundamentals

1st Edition - October 8, 1991

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  • Author: Norton G. McDuffie
  • eBook ISBN: 9781483221083

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Bioreactor Design Fundamentals presents the development in the bioreactor field. This book discusses the applications of biological kinetics and thermodynamics. Organized into seven chapters, this book begins with an overview of the design of biological reactors that involves determining operating conditions, sizing the reactor, controlling temperature and sterility, and controlling operating variables. This text then examines the significance of pH considerations in biological reactor and process design. Other chapters consider enzyme kinetics and the equations most commonly used as models for overall enzyme kinetics. This book discusses as well the mass transfer rates in bioreactors, which are significant because of their effects on some chemical reaction rates in transformations by enzymes or by living cells. The final chapter deals with the ideal state of the continuous stirred-tank reactors (CSTRs). This book is a valuable resource for biochemical engineers and industrial microbiologists.

Table of Contents

  • Preface

    1 Introduction

    2 Thermodynamics and Stoichiometry for Bioreactor Design


    Standard States

    pH and Buffers


    Energy Balances

    Phase Equilibrium Relationships

    Reaction Equilibrium

    3 Enzyme Kinetics

    Mathematical Models for Enzyme-Catalyzed Reactions

    Effect of Temperature on Enzymatic Reactions

    Effect of pH on Enzyme-Catalyzed Reactions

    Enzyme Inhibition

    Types of Inhibitors

    Reversibility of Inhibition

    Time-Dependent Deactivation

    Equilibrium Inhibition Models for Michaelis-Menten Kinetics

    Kinetics of Polymer Hydrolysis

    4 Mass-Transfer Fundamentals

    Mass-Transfer Limitations

    Intraphase Mass Transfer

    Gas-Liquid Mass Transfer

    Mass Transfer Through Membranes

    Mass Transfer Through Porous Structures

    Interphase Mass Transfer at Liquid-Liquid Interfaces

    Mass Transfer at Solid-Liquid Interfaces

    General Mass-Transfer Considerations

    5 Kinetics of Cellular Multiplication

    Nature of Cell Growth and Multiplication

    Monod Kinetics

    Stoichiometry for Substrate and Product Relationships

    Alternative Mathematical Models

    Temperature Effects on Cell Processes

    Effects of Other Environmental Factors

    Cell Growth Inhibition

    Mass-Transport and Physical Restraint Limitations

    Mixed Cultures

    Autotrophic Growth

    Rate Limit Determinations

    6 Enzyme Reactors


    Nonimmobilized Enzyme Systems

    Immobilized Enzyme Systems

    Stirred-Tank Bioreactors

    Plug-Flow Bioreactors

    Comparison of Plug-Flow and CSTR Reactors

    Reactor Combinations

    7 Cell Culture Bioreactors

    Types of Biological Growth Reactors

    CSTR Biological Growth Systems

    The Batch Stirred-Tank Culture System

    Fed-Batch Cultures

    Single Continuous-Flow CSTR without Recycle

    Graphic Analysis of Single and Multiple CSTRs

    Plug-Flow Reactors for Cell Growth

    Recycle Operations

    Continuous Culture of Photosynthetic Organisms

    Sterilization of Culture Media

    Scale-Up of Cell-Culture Bioreactors

    List of Symbols



Product details

  • No. of pages: 150
  • Language: English
  • Copyright: © Butterworth-Heinemann 1991
  • Published: October 8, 1991
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483221083

About the Author

Norton G. McDuffie

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