Bioreactor Design Fundamentals

1st Edition - October 8, 1991
Author: Norton G. McDuffie
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 2 1 0 8 - 3

Bioreactor Design Fundamentals presents the development in the bioreactor field. This book discusses the applications of biological kinetics and thermodynamics. Organized into… Read more

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Bioreactor Design Fundamentals presents the development in the bioreactor field. This book discusses the applications of biological kinetics and thermodynamics. Organized into seven chapters, this book begins with an overview of the design of biological reactors that involves determining operating conditions, sizing the reactor, controlling temperature and sterility, and controlling operating variables. This text then examines the significance of pH considerations in biological reactor and process design. Other chapters consider enzyme kinetics and the equations most commonly used as models for overall enzyme kinetics. This book discusses as well the mass transfer rates in bioreactors, which are significant because of their effects on some chemical reaction rates in transformations by enzymes or by living cells. The final chapter deals with the ideal state of the continuous stirred-tank reactors (CSTRs). This book is a valuable resource for biochemical engineers and industrial microbiologists.

Preface1 Introduction2 Thermodynamics and Stoichiometry for Bioreactor Design Thermodynamics Standard States pH and Buffers Stoichiometry Energy Balances Phase Equilibrium Relationships Reaction Equilibrium3 Enzyme Kinetics Mathematical Models for Enzyme-Catalyzed Reactions Effect of Temperature on Enzymatic Reactions Effect of pH on Enzyme-Catalyzed Reactions Enzyme Inhibition Types of Inhibitors Reversibility of Inhibition Time-Dependent Deactivation Equilibrium Inhibition Models for Michaelis-Menten Kinetics Kinetics of Polymer Hydrolysis4 Mass-Transfer Fundamentals Mass-Transfer Limitations Intraphase Mass Transfer Gas-Liquid Mass Transfer Mass Transfer Through Membranes Mass Transfer Through Porous Structures Interphase Mass Transfer at Liquid-Liquid Interfaces Mass Transfer at Solid-Liquid Interfaces General Mass-Transfer Considerations5 Kinetics of Cellular Multiplication Nature of Cell Growth and Multiplication Monod Kinetics Stoichiometry for Substrate and Product Relationships Alternative Mathematical Models Temperature Effects on Cell Processes Effects of Other Environmental Factors Cell Growth Inhibition Mass-Transport and Physical Restraint Limitations Mixed Cultures Autotrophic Growth Rate Limit Determinations6 Enzyme Reactors Overview Nonimmobilized Enzyme Systems Immobilized Enzyme Systems Stirred-Tank Bioreactors Plug-Flow Bioreactors Comparison of Plug-Flow and CSTR Reactors Reactor Combinations7 Cell Culture Bioreactors Types of Biological Growth Reactors CSTR Biological Growth Systems The Batch Stirred-Tank Culture System Fed-Batch Cultures Single Continuous-Flow CSTR without Recycle Graphic Analysis of Single and Multiple CSTRs Plug-Flow Reactors for Cell Growth Recycle Operations Continuous Culture of Photosynthetic Organisms Sterilization of Culture Media Scale-Up of Cell-Culture BioreactorsList of SymbolsReferencesIndex