Bioprocess Engineering

Bioprocess Engineering

Kinetics, Sustainability, and Reactor Design

2nd Edition - August 29, 2016

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  • Author: Shijie Liu
  • eBook ISBN: 9780444637932

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Bioprocess Engineering: Kinetics, Sustainability, and Reactor Design, Second Edition, provides a comprehensive resource on bioprocess kinetics, bioprocess systems, sustainability, and reaction engineering. Author Dr. Shijie Liu reviews the relevant fundamentals of chemical kinetics, batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction engineering, and bioprocess systems engineering, also introducing key principles that enable bioprocess engineers to engage in analysis, optimization, and design with consistent control over biological and chemical transformations. The quantitative treatment of bioprocesses is the central theme in this book, with more advanced techniques and applications being covered in depth. This updated edition reflects advances that are transforming the field, ranging from genetic sequencing, to new techniques for producing proteins from recombinant DNA, and from green chemistry, to process stability and sustainability. The book introduces techniques with broad applications, including the conversion of renewable biomass, the production of chemicals, materials, pharmaceuticals, biologics, and commodities, medical applications, such as tissue engineering and gene therapy, and solving critical environmental problems.

Key Features

  • Includes the mechanistic description of biotransformations and chemical transformations
  • Provides quantitative descriptions of bioprocesses
  • Contains extensive illustrative drawings, which make the understanding of the subject easy
  • Includes bioprocess kinetics and reactor analysis
  • Contains examples of the various process parameters, their significance, and their specific practical use
  • Incorporates sustainability concepts into the various bioprocesses


Senior undergraduate students and graduate students in Chemical and Bioprocess Engineering and Biological Engineering Research Engineers and Scientists in Biotechnology and Bioprocess Design

Table of Contents

  • Chapter 1. Introduction

    Chapter 2. An Overview of Biological Basics

    Chapter 3. An Overview of Chemical Reaction Analysis

    Chapter 4. Batch Reactor

    Chapter 5. Ideal Flow Reactors

    Chapter 6. Kinetic Theory and Reaction Kinetics

    Chapter 7 Parametric Estimation

    Chapter 8. Enzymes

    NEW! Chapter 9. Allosteric Enzymes and Regulations

    9.1. Reactions in Life

    9.2. Allostericity and cooperativity

    9.2.1 Single binding site and saturation binding

    9.2.2 Multiple binding sites and Morpheein mechanism

    9.3. Enzyme binding and transport

    9.4. Kinetics of allosteric enzyme

    9.5. Allosteric regulations

    9.6. Summary

    Recommended Reading Materials


    NEW! Chapter 10. Adsorption

    10.1 Introduction

    10.2 Thermodynamics of adsorption

    10.3 Ideal surface and Langmuir adsorption

    10.3.1 Collision theory and adsorption rate

    10.3.2 Langmuir adsorption isotherm

    10.4 Idealization of non-ideal adsorption and multilayer adsorption

    10.4.1 Idealization of non-uniform surface and surface interaction

    10.4.2 Multilayer adsorption kinetics

    10.4.3 Adsorption isotherm

    10.4.4 BET isotherm

    10.5 Pore Size and Surface Characterization

    10.6. Applications of adsorption

    10.7 Summary

    Recommended Reading Materials


    Chapter 11. Catalysis and Chemical Reactions on Solid Surfaces

    Chapter 12. Cell Growth and Metabolism

    Chapter 13. Kinetics of Cell Growth and Batch Cultivation

    Chapter 14. Cell Growth and Fermentation

    Chapter 15 Ideal Fed-Batch Reactor

    Chapter 16. Evolution and Genetic Engineering

    Chapter 17. Sustainability: Perspective

    Chapter 18 Sustainability and Stability

    Chapter 19. Mass Transfer Effects: Immobilized and Heterogeneous Reaction Systems

    Chapter 20. Bioreactor Design & Operation

    NEW! Chapter 21. Bioprocess Kinetics Experimental Design

    21.1 Introduction

    21.2 Identification of objectives

    21.3 Experimental design

    20.4 Model construction

    20.5 Summary

    Reading Materials


    NEW! Chapter 22. Bioprocess Safety

    22.1 Introduction

    22.2 Chemicals and materials safety

    22.3 Biosafety

    22.4 Chemical process hazard

    22.5 Bioprocess hazard

    22.6 Reactive hazard

    22.7 Summary

    Reading Materials


Product details

  • No. of pages: 1172
  • Language: English
  • Copyright: © Elsevier 2016
  • Published: August 29, 2016
  • Imprint: Elsevier
  • eBook ISBN: 9780444637932

About the Author

Shijie Liu

Shijie Liu
Dr. Shijie Liu is a professor of bioprocess engineering at the State University of New York – College of Environmental Science and Forestry (SUNY ESF), Syracuse, NY, USA. His contributions include volume averaging in porous media, kinetics of reactions on solid surfaces, cooperative adsorption theory, the theory of interactive enzymes, and the kinetic modeling of polyauxic growth / fermentation. Much of his childhood was spent in the country side of Sichuan Province in China, finished high school in 1978 from Luxi High School, in a little town just a few kilometers away from his home of birth. He graduated from Chengdu University of Science and Technology (now merged into Sichuan University) with a BS degree in Chemical Engineering in 1982. His early career started in the chemical industrial city of Lanzhou, China before moving to Canada. He obtained his PhD degree in Chemical Engineering from the University of Alberta in 1992 under Prof. Jacob H. Masliyah. Since then, he worked in the University of Alberta and Alberta Research Council before joining SUNY ESF in 2005. He has over 150 peer-reviewed publications today and maintains strong collaborations with colleagues in China from various universities. He taught a variety of courses including transport phenomena, numerical methods, mass transfer, chemical kinetics, pulp and paper technology, colloids and interfaces, chemical reaction engineering, bioreaction engineering, bioprocess kinetics and systems engineering, bioefinery processes, advanced biocatalysis, advanced bioprocess kinetics, and bioprocess engineering. Dr. Liu currently serves as the Editor-In-Chief of the Journal of Biobased Materials and Bioenergy, as well as the Editor-In-Chief of the Journal of Bioprocess Engineering and Biorefinery.

Affiliations and Expertise

College of Environmental Science and Forestry (SUNY ESF), State University of New York, NY, USA

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  • Chang G. Tue Oct 23 2018

    Great book for reviewing bioprocess

    Well organized and contain many examples