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Bioprocess Engineering - 2nd Edition - ISBN: 9780444637833, 9780444637932

Bioprocess Engineering

2nd Edition

Kinetics, Sustainability, and Reactor Design

Author: Shijie Liu
Paperback ISBN:
eBook ISBN: 9780444637932
Hardcover ISBN: 9780444637833
Imprint: Elsevier
Published Date: 29th August 2016
Page Count: 1172
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Bioprocess Engineering: Kinetics, Sustainability, and Reactor Design, Second Edition, provides a comprehensive resource on bioprocess kinetics, bioprocess systems, sustainability, and reaction engineering. Author Dr. Shijie Liu reviews the relevant fundamentals of chemical kinetics, batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction engineering, and bioprocess systems engineering, also introducing key principles that enable bioprocess engineers to engage in analysis, optimization, and design with consistent control over biological and chemical transformations.

The quantitative treatment of bioprocesses is the central theme in this book, with more advanced techniques and applications being covered in depth. This updated edition reflects advances that are transforming the field, ranging from genetic sequencing, to new techniques for producing proteins from recombinant DNA, and from green chemistry, to process stability and sustainability.

The book introduces techniques with broad applications, including the conversion of renewable biomass, the production of chemicals, materials, pharmaceuticals, biologics, and commodities, medical applications, such as tissue engineering and gene therapy, and solving critical environmental problems.

Key Features

  • Includes the mechanistic description of biotransformations and chemical transformations
  • Provides quantitative descriptions of bioprocesses
  • Contains extensive illustrative drawings, which make the understanding of the subject easy
  • Includes bioprocess kinetics and reactor analysis
  • Contains examples of the various process parameters, their significance, and their specific practical use
  • Incorporates sustainability concepts into the various bioprocesses


Senior undergraduate students and graduate students in Chemical and Bioprocess Engineering and Biological Engineering Research Engineers and Scientists in Biotechnology and Bioprocess Design

Table of Contents

Chapter 1. Introduction

Chapter 2. An Overview of Biological Basics

Chapter 3. An Overview of Chemical Reaction Analysis

Chapter 4. Batch Reactor

Chapter 5. Ideal Flow Reactors

Chapter 6. Kinetic Theory and Reaction Kinetics

Chapter 7 Parametric Estimation

Chapter 8. Enzymes

NEW! Chapter 9. Allosteric Enzymes and Regulations

9.1. Reactions in Life

9.2. Allostericity and cooperativity

9.2.1 Single binding site and saturation binding

9.2.2 Multiple binding sites and Morpheein mechanism

9.3. Enzyme binding and transport

9.4. Kinetics of allosteric enzyme

9.5. Allosteric regulations

9.6. Summary

Recommended Reading Materials


NEW! Chapter 10. Adsorption

10.1 Introduction

10.2 Thermodynamics of adsorption

10.3 Ideal surface and Langmuir adsorption

10.3.1 Collision theory and adsorption rate

10.3.2 Langmuir adsorption isotherm

10.4 Idealization of non-ideal adsorption and multilayer adsorption

10.4.1 Idealization of non-uniform surface and surface interaction

10.4.2 Multilayer adsorption kinetics

10.4.3 Adsorption isotherm

10.4.4 BET isotherm

10.5 Pore Size and Surface Characterization

10.6. Applications of adsorption

10.7 Summary

Recommended Reading Materials


Chapter 11. Catalysis and Chemical Reactions on Solid Surfaces

Chapter 12. Cell Growth and Metabolism

Chapter 13. Kinetics of Cell Growth and Batch Cultivation

Chapter 14. Cell Growth and Fermentation

Chapter 15 Ideal Fed-Batch Reactor

Chapter 16. Evolution and Genetic Engineering

Chapter 17. Sustainability: Perspective

Chapter 18 Sustainability and Stability

Chapter 19. Mass Transfer Effects: Immobilized and Heterogeneous Reaction Systems

Chapter 20. Bioreactor Design & Operation

NEW! Chapter 21. Bioprocess Kinetics Experimental Design

21.1 Introduction

21.2 Identification of objectives

21.3 Experimental design

20.4 Model construction

20.5 Summary

Reading Materials


NEW! Chapter 22. Bioprocess Safety

22.1 Introduction

22.2 Chemicals and materials safety

22.3 Biosafety

22.4 Chemical process hazard

22.5 Bioprocess hazard

22.6 Reactive hazard

22.7 Summary

Reading Materials



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© Elsevier 2016
29th August 2016
Paperback ISBN:
eBook ISBN:
Hardcover ISBN:

About the Author

Shijie Liu

Shijie Liu

Dr. Shijie Liu is a professor of bioprocess engineering at the State University of New York – College of Environmental Science and Forestry (SUNY ESF), Syracuse, NY, USA. His contributions include volume averaging in porous media, kinetics of reactions on solid surfaces, cooperative adsorption theory, the theory of interactive enzymes, and the kinetic modeling of polyauxic growth / fermentation. Much of his childhood was spent in the country side of Sichuan Province in China, finished high school in 1978 from Luxi High School, in a little town just a few kilometers away from his home of birth. He graduated from Chengdu University of Science and Technology (now merged into Sichuan University) with a BS degree in Chemical Engineering in 1982. His early career started in the chemical industrial city of Lanzhou, China before moving to Canada. He obtained his PhD degree in Chemical Engineering from the University of Alberta in 1992 under Prof. Jacob H. Masliyah. Since then, he worked in the University of Alberta and Alberta Research Council before joining SUNY ESF in 2005. He has over 150 peer-reviewed publications today and maintains strong collaborations with colleagues in China from various universities. He taught a variety of courses including transport phenomena, numerical methods, mass transfer, chemical kinetics, pulp and paper technology, colloids and interfaces, chemical reaction engineering, bioreaction engineering, bioprocess kinetics and systems engineering, bioefinery processes, advanced biocatalysis, advanced bioprocess kinetics, and bioprocess engineering. Dr. Liu currently serves as the Editor-In-Chief of the Journal of Biobased Materials and Bioenergy, as well as the Editor-In-Chief of the Journal of Bioprocess Engineering and Biorefinery.

Affiliations and Expertise

College of Environmental Science and Forestry (SUNY ESF), State University of New York, NY, USA

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