Bioprocess Engineering

1st Edition

Kinetics, Sustainability, and Reactor Design

Authors: Shijie Liu
Hardcover ISBN: 9780444595256
eBook ISBN: 9780444595225
Imprint: Elsevier
Published Date: 28th September 2012
Page Count: 1000
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Bioprocess Engineering involves the design and development of equipment and processes for the manufacturing of products such as food, feed, pharmaceuticals, nutraceuticals, chemicals, and polymers and paper from biological materials. It also deals with studying various biotechnological processes. "Bioprocess Kinetics and Systems Engineering" first of its kind contains systematic and comprehensive content on bioprocess kinetics, bioprocess systems, sustainability and reaction engineering. Dr. Shijie Liu reviews the relevant fundamentals of chemical kinetics-including batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction engineering, and bioprocess systems engineering- introducing key principles that enable bioprocess engineers to engage in the analysis, optimization, design and consistent control over biological and chemical transformations. The quantitative treatment of bioprocesses is the central theme of this book, while more advanced techniques and applications are covered with some depth. Many theoretical derivations and simplifications are used to demonstrate how empirical kinetic models are applicable to complicated bioprocess systems.

Key Features

  • Contains extensive illustrative drawings which make the understanding of the subject easy
  • Contains worked examples of the various process parameters, their significance and their specific practical use
  • Provides the theory of bioprocess kinetics from simple concepts to complex metabolic pathways
  • Incorporates sustainability concepts into the various bioprocesses


Bioprocess Engineering Students and Bioprocess Engineers, along with Chemical Engineers

Table of Contents



Greek Symbols



Chapter 1. Introduction

1.1 Biological Cycle

1.2 Green Chemistry

1.3 Sustainability

1.4 Biorefinery

1.5 Biotechnology and Bioprocess Engineering

1.6 Mathematics, Biology, and Engineering

1.7 The Story of Penicillin: The Dawn of Bioprocess Engineering

1.8 Bioprocesses: Regulatory Constraints

1.9 The Pillars of Bioprocess Kinetics and Systems Engineering

1.10 Summary

Further Reading


Chapter 2. An Overview of Biological Basics

2.1 Cells and Organisms

2.2 Stem Cell

2.3 Cell Chemistry

2.4 Cell Feed

2.5 Summary

Further Reading


Chapter 3. An Overview of Chemical Reaction Analysis

3.1 Chemical Species

3.2 Chemical Reactions

3.3 Reaction Rates

3.4 Approximate Reactions

3.5 Rate Coefficients

3.6 Stoichiometry

3.7 Yield and Yield Factor

3.8 Reaction Rates Near Equilibrium

3.9 Energy Regularity

3.10 Classification of Multiple Reactions and Selectivity

3.11 Coupled Reactions

3.12 Reactor Mass Balances

3.13 Reaction Energy Balances

3.14 Reactor Momentum Balance

3.15 Ideal Reactors

3.16 Bioprocess Systems Optimization

3.17 Summary

Further Reading


Chapter 4. Batch Reactor

4.1 Isothermal Batch Reactors

4.2 Batch Reactor Sizing

4.3 Non-Isothermal Batch Reactors

4.4 Numerical Solutions of Batch Reactor Problems

4.5 Summary

Further Reading


Chapter 5. Ideal Flow Reactors

5.1 Flow Rate, Residence Time, Space Time, Space Velocity, Dilution Rate

5.2 Plug Flow Reactor

5.3 Gasification and Fischer–Tropsch Technology


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About the Author

Shijie Liu

Dr. Shijie Liu is a professor of bioprocess engineering at the State University of New York – College of Environmental Science and Forestry (SUNY ESF), Syracuse, NY, USA. His contributions include volume averaging in porous media, kinetics of reactions on solid surfaces, cooperative adsorption theory, the theory of interactive enzymes, and the kinetic modeling of polyauxic growth / fermentation. Much of his childhood was spent in the country side of Sichuan Province in China, finished high school in 1978 from Luxi High School, in a little town just a few kilometers away from his home of birth. He graduated from Chengdu University of Science and Technology (now merged into Sichuan University) with a BS degree in Chemical Engineering in 1982. His early career started in the chemical industrial city of Lanzhou, China before moving to Canada. He obtained his PhD degree in Chemical Engineering from the University of Alberta in 1992 under Prof. Jacob H. Masliyah. Since then, he worked in the University of Alberta and Alberta Research Council before joining SUNY ESF in 2005. He has over 150 peer-reviewed publications today and maintains strong collaborations with colleagues in China from various universities. He taught a variety of courses including transport phenomena, numerical methods, mass transfer, chemical kinetics, pulp and paper technology, colloids and interfaces, chemical reaction engineering, bioreaction engineering, bioprocess kinetics and systems engineering, bioefinery processes, advanced biocatalysis, advanced bioprocess kinetics, and bioprocess engineering. Dr. Liu currently serves as the Editor-In-Chief of the Journal of Biobased Materials and Bioenergy, as well as the Editor-In-Chief of the Journal of Bioprocess Engineering and Biorefinery.

Affiliations and Expertise

College of Environmental Science and Forestry (SUNY ESF), State University of New York, NY, USA


"Combining biology and chemical engineering, Liu presents this overview of bioprocess engineering, applying typical techniques of the chemical industry to biosynthetic processes…Although formulated as a textbook, the level of detail would also make this suitable as a laboratory reference."--Reference & Research Book News, October 2013