Bioprocess Development: An Interdisciplinary Challenge:
Steps in Bioprocess Development: A Typical New Product from Recombinant DNA.
A Quantitative Approach.
Introduction to Engineering Calculations:
Physical Variables, Dimensions and Units.
Force and Weight.
Standard Conditions and Ideal Gases.
Physical and Chemical Property Data.
Presentation and Analysis of Data:
Errors in Data and Calculations.
Presentation of Experimental Data.
Graph Paper with Logarithmic Coordinates.
General Procedures for Plotting Data.
Process Flow Diagrams.
Material and Energy Balances:
Law of Conservation of Mass.
Procedure for Material-Balance Calculations.
Material-Balance Worked Examples.
Material Balances with Recycle, By-Pass and Purge Streams.
Stoichiometry of Growth and Product Formation.
Basic Energy Concepts.
General Energy-Balance Equations.
Enthalpy Calculation Procedures.
Enthalpy Change in Non-Reactive Processes.
Procedure for Energy-Balance Calculations without Reaction.
Energy-Balance Worked Examples without Reaction.
Enthalpy Change Due to Reaction.
Heat of Reaction for Processes with Biomass Production.
Energy-Balance Equation for Cell Culture.
Fermentation Energy-Balance Worked Examples.