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Part I: History and Reflections
Section 1. Solution Methods
Binding: A Polemic and Rough Guide Nichola C. Garbett, Jonathan B. Chaires
Linked Equilibria in Regulation of Transcription Initiation Dorothy Beckett
Biosensor-Surface Plasmon Resonance Methods for Quantitative Analysis of Biomolecular Interactions Farial A. Tanious, Binh Nguyen, and W. David Wilson
Isothermal Titration Calorimetry: Experimental Design, Data Analysis, and Probing Macromolecule/Ligand Binding and Kinetic Interactions Matthew W. Freyer and Edwin A. Lewis
Differential Scanning Calorimetry Charles H. Spink
Analytical Ultracentrifugation: A) Sedimentation Velocity, B) Sedimentation Equilibrium Tom Laue, Tom Moody, James Cole, and Jeff Lary
Determination of membrane protein molecular weights and association equilibrium constants using sedimentation equilibrium and sedimentation velocity Nancy K. Burgess, Ann Marie Stanley, and Karen G. Fleming
Basic Aspects of Absorption and Fluorescence Spectroscopy and Resonance Energy Transfer Methods Susan Bane and Natasha Shanker
Applications of Fluorescence Anisotropy to the Study of Protein-DNA Interactions Vince J. LiCata and Andy J. Wowor
Circular Dichroism and Its Application to the Study of Biomolecules Stephen R. Martin and Maria J. Schilstra
Folding and Stability Timothy O. Street, Naomi Courtemanche and Doug Barrick
Hydrodynamic shape modelling of analytical ultracentrifugation data Olwyn Byron
X-ray and neutron scattering data and their constrained molecular modelling Stephen J Perkins, Azubuike I. Okemefuna, Anira N. Fernando, Alexandra Bonner, Hannah E. Gilbert and Patricia B. Furtado
Structural Investigations into Microtubule-MAP Complexes Andreas Hoenger and Heinz Gross
Rapid Kinetic Techniques John F. Eccleston, Stephen Martin, and Maria J. Schilstra
Mutagenic Analysis of the Membrane Protein Functional Mechanisms: Bacteriorhodopsin as a Model Example George J. Turner
Quantifying DNA-protein interactions by single molecule stretching Mark C. Williams, Ioulia Rouzina, and Richard L. Karpel
Isotopomer-based metabolomic analysis by NMR and mass spectrometry Andrew N Lane, Teresa W-M. Fan, and Richard M. Higashi
Following molecular transitions with single residue spatial and millisecond time resolution Inna Shcherbakova, Somdeb Mitra, Robert Beer and Michael Brenowitz
Methods and applications of site-directed spin labeling EPR spectroscopy Candice S. Klug and Jimmy B. Feix
Fluorescence Correlation Spectroscopy and its application to the characterization of molecular properties and interactions Hacène Boukari and Dan L. Sackett
Practical Guide to Osmolytes Jorg Rosgen and Daniel Harries
Stupid Statistics Joel Tellinghuisen
Nonlinear Least Squares Fitting Methods Michael L. Johnson
Methods for Simulating the Dynamics of Complex Biological Processes Maria J Schilstra, Stephen R. Martin, and Sarah M. Keating
Computational Methods for Biomolecular Electrostatics Feng Dong, Brett Olsen and Nathan A. Baker
Ligand effects on the protein ensemble: Unifying the descriptions of ligand binding, local conformational fluctuations, and protein stability Steven T Whitten, Bertrand García-Moreno E., and Vincent J. Hilser
Molecular Modeling of Cytoskeletal Proteins Xiange Zheng and David Sept
Mathematical Modeling of Cell Motility Anders E. Carlsson and David Sept
Driven in part by the development of genomics, proteomics, and bioinformatics as new disciplines, there has been a tremendous resurgence of interest in physical methods to investigate macromolecular structure and function in the context of living cells. This volume in Methods in Cell Biology is devoted to biophysical techniques in vitro and their applications to cellular biology. Biophysical Tools for Biologists covers methods-oriented chapters on fundamental as well as cutting-edge techniques in molecular and cellular biophysics. This book is directed toward the broad audience of cell biologists, biophysicists, pharmacologists, and molecular biologists who employ classical and modern biophysical technologies or wish to expand their expertise to include such approaches. It will also interest the biomedical and biotechnology communities for biophysical characterization of drug formulations prior to FDA approval.
- Describes techniques in the context of important biological problems
- Delineates critical steps and potential pitfalls for each method
- Includes full-color plates to illustrate techniques
Cell biologists, biophysicists, pharmacologists, and molecular biologists.
- No. of pages:
- © Academic Press 2007
- 5th November 2007
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
University of Mississippi Medical Center, Jackson, USA
Professor of Biochemistry and Marine Biology at Northeastern University, promoted 1996. Joined Northeastern faculty in 1987. Previously a faculty member in Dept. of Biochemistry at the University of Mississippi Medical Center, 1983-1987.Principal Investigator in the U.S. Antarctic Program since 1984. Twelve field seasons "on the ice" since 1981. Research conducted at Palmer Station, Antarctica, and McMurdo Station, Antarctica.Research areas: Biochemical, cellular, and physiological adaptation to low and high temperatures. Structure and function of cytoplasmic microtubules and microtubule-dependent motors from cold-adapted Antarctic fishes. Regulation of tubulin and globin gene expression in zebrafish and Antarctic fishes. Role of microtubules in morphogenesis of the zebrafish embryo. Developmental hemapoiesis in zebrafish and Antarctic fishes. UV-induced DNA damage and repair in Antarctic marine organisms.
Northeastern University, Boston, MA, USA
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