
Biophysical Characterization of Proteins in Developing Biopharmaceuticals
Description
Key Features
- Presents basic protein characterization methods and tools applicable to (bio)pharmaceutical research and development
- Highlights the capabilities and limitations of each technique
- Discusses the underlining science of each tool
- Empowers industrial biophysical chemists by providing a roadmap for applying biophysical tools
- Outlines the needs for new characterization and analytical tools in the biopharmaceutical industry
Readership
Researchers in academia and corporate laboratories who develop new instrumental methods for characterisation of proteins in general and biopharmaceutical proteins specifically; researchers in industry who develop these proteins and need characterisation methods
Table of Contents
I: Proteins and Biophysical Characterization in the Biopharmaceutical Industry
1. The Complexity of Protein Structure and the Challenges it Poses in Developing Biopharmaceuticals
2. Biophysical Characterization and Its Role in the Biopharmaceutical Industry
3. Biopharmaceutical Industry's Biophysical ToolboxII: The Selected Biophysical Tools in the Biopharmaceutical Industry
4. An Introduction and Hierarchical Organization of the Biophysical Tool
5. The Value of UV, Fluorescence, and FTIR Spectroscopy in Biopharmaceutical Development
6. Circular Dichroism Spectroscopy for Protein Characterization: Biopharmaceutical Applications
7. Size-Exclusion Chromatograph (SEC) in Biopharmaceutical Process Development
8. Scattering Techniques for the Characterization of Biopharmaceuticals
9. Characterizing Biopharmaceuticals using Analytical Ultracentrifugation
10. Sub-visible and Visible Particle Analysis in Biopharmaceutical Research and Development
11. Differential Scanning Calorimetry in the Biopharmaceutical Sciences
12. Biophysical Mass Spectrometry for Biopharmaceutical Process Development: Focus on Hydrogen/Deuterium Exchange
13. One- and Two-Dimensional NMR Techniques for Biopharmaceuticals
14. Use of Chromatography and Electrophoresis for indirectly assessing Biophysical CharacterizationIII: Concluding Remarks on the Biophysical Characterization of Biopharmaceuticals
15. Biophysically Characterization of very large Biopharmaceuticals
16. Statistical Analysis of Biophysical Characterization Data
17. Biopharmaceutical Developability
18. Technical Decision-making dealing with Biophysical Characterization Data
19. Biophysical Characterization: An Integral Part of the "Totality of the Evidence" Concept
Product details
- No. of pages: 586
- Language: English
- Copyright: © Elsevier 2019
- Published: September 1, 2019
- Imprint: Elsevier
- eBook ISBN: 9780444641748
- Paperback ISBN: 9780444641731
About the Editors
Damian Houde
Affiliations and Expertise
Steven A. Berkowitz
Dr. Berkowitz received a B.S. degree in Biology from Fairleigh Dickinson University and a Ph.D. degree in Biochemistry from New York University. He then spent several years as a post-doctoral fellow at Yale University and the NIH. After his post-doctoral work Dr. Berkowitz held various positions at Celanese Research Company, J.T. Baker, and Lederle Laboratories before taking his present position at Biogen Idec.
Affiliations and Expertise
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