Biophysical Aspects of Cardiac Muscle - 1st Edition - ISBN: 9780125061506, 9780323150705

Biophysical Aspects of Cardiac Muscle

1st Edition

Editors: Martin Morad
eBook ISBN: 9780323150705
Imprint: Academic Press
Published Date: 1st January 1978
Page Count: 430
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Description

Biophysical Aspects of Cardiac Muscle is based on the proceedings of the first cardiac muscle symposium held May 1977, at the Pahlavi University in Shiraz, Iran. The compendium deals with topics on the gating processes in excitable membranes; ionic transport mechanisms in the generation of cardiac action potential plateau; structure and function of the sarcotubular system; excitation-contraction coupling in heart muscle; and mechanisms of drug action in cardiac muscle. The book will be of value to physicians, cardiologists, physiologists, and researchers in the field of medicine and anatomy.

Table of Contents


List of Contributors


Foreword


Preface


I. The A. F. Huxley Symposium Lecture


On Arguing from One Kind of Muscle to Another


II. Gating Processes in Excitable Membranes


Intramembranous Charge Movement and Control of Cellular Functions by Membrane Voltage


Electrical Properties of Amphibian Slow Muscle Fibers


Charge Movement in the Membrane of Striated Muscle


Local Anesthetic Action on Inactivation of the Na Channel in Nerve and Skeletal Muscle: Possible Mechanisms for Antiarrhythmic Agents


Models of Gating Current and Sodium Conductance Inactivation


III. Ionic Transport Mechanisms in Generation of Cardiac Action Potential Plateau


Inward Rectifier: Carriers Vs. Channels


Calcium Transport in Excitable Membranes


Voltage Dependence of Tetrodotoxin Action in Mammalian Cardiac Muscle


The Effect of Cesium Ions on 42K Efflux in Cardiac Purkinje Fibers


Potassium Currents in Ventricular Muscle


General Discussion on "The Inward Rectifier"


IV. Structure and Function of the Sarcotubular System


Introductory Remarks: Structural Basis of E-C Coupling


Three-Dimensional Structure of Muscle Fiber


Optical Indications of Excitation-Contraction Coupling in Striated Muscle


Fluorescence Signals from Skeletal Muscle Fibers


The Aequorin Signal During Activation of Muscle


V. E-C Coupling in Heart Muscle


The Effect of Extracellular Potassium on the Excitation Contraction Coupling in Frog Heart


A Ca-Transport System for Activation of Tension in Frog Ventricular Muscle


E-C Coupling Studies on Skinned Cardiac Fibers


Membrane Control of Cardiac Contractile Systems


VI. Mechanisms of Drug Action in Cardiac Muscle


Digitalis: In

Details

No. of pages:
430
Language:
English
Copyright:
© Academic Press 1978
Published:
Imprint:
Academic Press
eBook ISBN:
9780323150705

About the Editor

Martin Morad

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