Biomedical Imaging Instrumentation

Biomedical Imaging Instrumentation

Applications in Tissue, Cellular and Molecular Diagnostics

1st Edition - November 26, 2021

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  • Editors: Mrutyunjay Suar, Namrata Misra, Neel Sarovar Bhavesh
  • Paperback ISBN: 9780323856508
  • eBook ISBN: 9780323899918

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Biomedical Imaging Instrumentation: Applications in Tissue, Cellular and Molecular Diagnostics provides foundational information about imaging modalities, reconstruction and processing, and their applications. The book provides insights into the fundamental of the important techniques in the biomedical imaging field and also discusses the various applications in the area of human health. Each chapter summarizes the overview of the technique, the various applications, and the challenges and recent innovations occurring to further improve the technique. Chapters include Biomedical Techniques in Cellular and Molecular Diagnostics, The Role of CT Scan in Medical and Dental Imaging, Ultrasonography - Technology & Applications in Clinical Radiology, Magnetic Resonance Imaging, Instrumentation and Utilization of PET-CT Scan in Oncology, Gamma Camera and SPECT, Sentinel of Breast Cancer Screening; Hyperspectral Imaging; PA Imaging; NIR Spectroscopy, and The Advances in Optical Microscopy and its Applications in Biomedical Research. This book is ideal for supporting learning, and is a key resource for students and early career researchers in fields such as medical imaging and biomedical instrumentation.

Key Features

  • A basic, fundamental, easy to understand introduction to medical imaging techniques
  • Each technique is accompanied with detailed discussion on the application in the biomedical field in an accessible and easy to understand way
  • Provides insights into the limitations of each technology and innovations that are occurring related to that technology


Graduate and master’s students in the fields of imaging and biomedical instrumentation. Researchers in the fields of imaging, biomedical instrumentation, biotechnology, cellular biology, molecular biology

Table of Contents

  • Cover Image
  • Title Page
  • Copyright
  • Table of Contents
  • Contributors
  • Preface
  • Chapter 1 Biomedical techniques in cellular and molecular diagnostics: Journey so far and the way forward
  • Abstract
  • 1.1 Biomedical imaging technology
  • 1.2 Way forward
  • References
  • Chapter 2 Role of CT scan in medical and dental imaging
  • Abstract
  • 2.1 Introduction to computed tomography
  • 2.2 Benefits and uses of CT scan
  • 2.3 Issues regarding CT scan
  • 2.4 Technical parameters and clinical applications
  • 2.5 Advancement in CT scans
  • 2.6 Application of CBCT in dentistry
  • 2.7 Conclusion
  • References
  • Chapter 3 Ultrasonography technology and applications in clinical radiology
  • Abstract
  • 3.1 Introduction
  • 3.2 Properties of sound
  • 3.3 Interaction between ultrasound and matter
  • 3.4 Fundamental technology
  • 3.5 Instrumentation and image formation
  • 3.6 Image representation and clinical application
  • 3.7 Conclusion
  • Chapter 4 Magnetic resonance imaging: Basic principles and advancement in clinical and diagnostics approaches in health care
  • Abstract
  • 4.1 Introduction
  • 4.2 Basic principles of MRI
  • 4.3 Components of MRI
  • 4.4 The basic concept of image acquisition and formation in an mri system
  • 4.5 Contrast agents used in MRI
  • 4.6 Intravenous agents
  • 4.7 MRI contrast agents: based on the specific area of interest
  • 4.8 Types of MRI and their applications
  • 4.9 Current clinical applications of mri in cardiovascular diseases
  • 4.10 Role of MRI in diagnosis, staging, and disease evaluation in cancers
  • 4.11 Contraindications and limitations of MRI
  • 4.12 Conclusion
  • References
  • Chapter 5 Current update about instrumentation and utilization of PET-CT scan in oncology and human diseases
  • Abstract
  • 5.1 Introduction
  • 5.2 PET imaging and instrumentation
  • 5.3 Clinical significances of PET in cancer
  • 5.4 Role of PET in the diagnosis of human diseases other than cancer
  • 5.5 Conclusion
  • References
  • Chapter 6 Revolutionizing medical diagnosis with SPECT imaging: Clinical applications of a nuclear imaging technology
  • Abstract
  • 6.1 Introduction
  • 6.2 Components and working of spect imaging device
  • 6.3 Spect applications
  • 6.4 Targeted imaging of prostate cancer with radioligands
  • 6.5 Spect imaging using 67ga-citrate spect/ct in lymphoma
  • 6.6 Spect imaging: nononcologic diseases
  • 6.7 Conclusion
  • References
  • Chapter 7 Mammography—sentinel of breast cancer management
  • Abstract
  • 7.1 Introduction
  • 7.2 Evolution of mammography
  • 7.3 Dissecting the mammography machine
  • 7.4 How a mammogram is captured
  • 7.5 Deciphering a mammogram
  • 7.6 Limitations
  • 7.7 Recent advances in mammography
  • 7.8 Alternatives
  • 7.9 Conclusion
  • References
  • Chapter 8 Hyperspectral Imaging: Current and Potential Clinical Applications
  • Abstract
  • 8.1 Introduction
  • 8.2 Concept
  • 8.3 Principles
  • 8.4 Techniques
  • 8.5 Analysis
  • 8.6 Biomedical uses
  • 8.7 Use externally to the human body
  • 8.8 Use in endoscopies
  • 8.9 Applications in surgery
  • 8.10 Applications for imaging the eye
  • 8.11 In vitro imaging
  • 8.12 Conclusion
  • References
  • Chapter 9 PA Imaging: A promising tool for targeted therapeutic implications in Cancer
  • Abstract
  • 9.1 Introduction
  • 9.2 Angiogenesis
  • 9.3 Metastasis
  • 9.4 Nanomedicine
  • 9.5 Biomedical applications of PAI in cancer
  • References
  • Further reading
  • Chapter 10 Near-infrared spectroscopy: An important noninvasive and sensitive tool for point-of-care biosensing application
  • Abstract
  • 10.1 Introduction
  • 10.2 Fundamentals of near-infrared spectroscopy
  • 10.3 Instrumentation of near-infrared spectrophotometer
  • 10.4 Analyzing an infrared spectrum
  • 10.5 General applications of near-infrared spectroscopy
  • 10.6 Nanomaterial-assisted near-infrared spectroscopy–based biosensing
  • References
  • Chapter 11 Advances in Microscopy and Their Applications in Biomedical Research
  • Abstract
  • 11.1 Microscopy as an integral part of biomedical research
  • 11.2 Photon-based imaging
  • 11.3 Automated imaging workstations for optical microscopy
  • 11.4 Near-field scanning optical microscopy (NSOM): Principle and biomedical applications
  • 11.5 Electron-based imaging: electron microscopy (EM)
  • 11.6 Resolution for photon-based and electron-based microscopes
  • 11.7 Conclusion
  • References
  • Index

Product details

  • No. of pages: 238
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: November 26, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780323856508
  • eBook ISBN: 9780323899918

About the Editors

Mrutyunjay Suar

Dr. Suar is a PhD in Molecular Microbiology from University of Delhi and Postdoc at ETH Zurich from 2004-2007. In June 2007 he joined KIIT University and established the School of Biotechnology. During this short span of time, the School of Biotechnology became a centre of excellence, supported by the Department of Biotechnology, Govt of India. Dr. Suar is involved in research related to interdisciplinary science with specialized focus on infection biology. His research group includes multidimensional researchers working on bacterial infection and development of vaccines. He is also involved in research related to nanobiotechnology focusing on development of nanomaterials for health application and understanding their toxicological aspects with different animal models. He established KIIT Technology Business Incubator (KIIT-TBI) in 2009 as the CEO, nurturing 200+companies in the area of engineering, energy, biotechnology and allied areas. He has received several recognitions including the American Society of Microbiology (ASM) Professorship award in 2012 during a visit to UCLA, USA; GP Chatterjee memorial award during 102nd Indian Science Congress and the Future Young Technical Leaders by STARS Switzerland in 2010. He also attended the Global Entrepreneurship leadership Symposium at HAAS Business School, USA and visited UC Berkley.

Affiliations and Expertise

Director General R&D and KIIT University CEO, KIIT-Technology Business Incubator, Bhubaneswar, India

Namrata Misra

Namrata Misra PhD received a M.Sc. degree in Bioinformatics from IIT (BHU) Varanasi, India, and a Ph.D. degree in Biological Science from AcSIR - Academy of Scientific & Innovative Research, CSIR-IMMT. She also received National Post-Doctoral Fellowship from Science and Engineering Research Board, Department of Science & Technology, Government of India. She is currently an Assistant Professor in the Department of Biotechnology, KIIT University. She is also the Head Bio innovations at KIIT Technology Business Incubator, among other key positions. Her research focus is on study of vital metabolic pathways and in-depth sequence-structural analysis of underpinning enzymes and also vaccine development using computational approach. She has also developed several cutting-edge computations tools, databases and webservers. She has authored or coauthored more than 30 international journal publications, and book chapters. She is the principal Investigator of a grant examining the metabolic pathways of algae using system biology approach for biofuel production. She has received the prestigious Odisha Young Scientist Award-2019 by Science and Technology Department of Government of Odisha and also the Best Researcher Award for 2012 at CSIR-IMMT, Bhubaneswar. Dr. Misra has led a number of workshops and training programs on innovation and entrepreneurship across several Institutes. She regularly mentors to students, startups and many young academicians to facilitate the translation of research discovery from lab to market and product development in healthcare sector. She has also visited to University of Edinburgh -UK under the Training-SinnoLABs Managers program in 2018 under the EU Erasmus Mundus Program. Also, she was selected to attend the ENPRENDIA Training of trainers and management meeting in Santiago de Compostela, Spain in January 2020.

Affiliations and Expertise

Assistant Professor, KIIT School of Biotechnology; Head, Bio-innovations, KIIT Technology Business Incubator, KIIT Deemed to Be University, Bhubaneswar, India

Neel Sarovar Bhavesh

Dr. Neel Sarovar Bhavesh is Group Leader at the International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India. His group uses an interdisciplinary approach encompassing a wide array of biophysical, biochemical and molecular biology techniques for understanding the structure and function of macromolecules with special thrust on molecular mechanism of Protein-RNA interactions. He is member of the editorial board of Nature Scientific Reports and reviews scientific manuscripts for international journals in the fields of structural biology and grant applications from various granting bodies in India. He presents regularly his research activity at international meetings and seminars.

Affiliations and Expertise

Group Leader, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India

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