Biomechanics of the Aorta

Biomechanics of the Aorta

Modelling for Patient Care

1st Edition - August 1, 2023

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  • Editors: T. Christian Gasser, Stéphane Avril, John Elefteriades
  • Hardcover ISBN: 9780323954846

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Description

Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.

Key Features

  • Represents a comprehensive means for those involved in the aortic research and the related developments in the industry
  • Introduces the most recent imaging technologies to characterize factors, such as aortic geometry, mechanical properties of the aortic tissue, and the local cellular activity in the vessel wall
  • Synthesizes advances in vascular biomechanics, medical imaging and computational finite element fluid and solid models to increase understanding of aorta function

Readership

Graduate students, post-docs, and professionals in biomedical and biomechanical engineering, biomedical and clinical researchers, all who need to: understand fundamental properties of the aorta, conduct experimental procedures, perform animal experiments, design and test clinical devices, and develop biomechanical finite element computations of the aorta

Table of Contents

  • Part 1 Anatomy, Biology, Physiopathology
    1. Physiopathology
    2. Genetics and aortic mechanisms
    3. Patho-Physiology and mechanobiology of the aortic valve
    4. Mechanobiology of aortic cells
    5. Clinical treatment options

    Part 2 Imaging and tissue/rheology characterization
    6. Rheology of aortic tissue - novel methods
    7. Imaging aortic flows - 4DMRI
    8. US imaging for aortic biomechanics
    9. Functional imaging FDG PET
    10. Image processing – deep learning for model reconstruction

    Part 3 Tissue modelling and rupture
    11. Aortic valves modelling
    12. AAA and thrombus modelling
    13. Aneurysm growth mechanical and biology coupled
    14. Rupture modelling - novel approaches
    15. Multiscale modeling from protein to aortic tissue

    Part 4 Flow modelling and algorithm
    16. Multiphysics flow modeling in the aorta
    17. Novel approaches in FSI for the aorta
    18. Turbulence modeling of blood flow
    19. Inverse problems in aortic flow modelling
    20. Modeling of Flow induced mechanosignaling
    21. Reduced order modeling

    Part 5 Applications
    22. TAVI aortic valve
    23. AAA rupture prediction
    24. (T)EVAR simulation
    25. FSI in aortic dissections
    26. Biomechanics of drug treatment
    27. Artificial Intelligence-based approaches

Product details

  • No. of pages: 450
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: August 1, 2023
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323954846

About the Editors

T. Christian Gasser

T. Christian Gasser is Professor of Biomechanics at KTH Royal Institute of Technology in Stockholm, Sweden, and Adjunct Professor at the University of Southern Denmark in Odense, Denmark. Professor Gasser is principal founder of VASCOPS GmbH, Graz, Austria and ARTEC Vascular Diagnosis AB, Stockholm Sweden. His scientific interest relates to vascular biomechanical problems, with particular emphasis on numerical techniques to solve clinically-relevant questions. Constitutive models developed by Professor Gasser have been implemented in many major Finite Element simulation packages, and translational research led to diagnostic software that is used at many clinical centers. He has authored almost 100 papers published in peer-reviewed premium journals, two international patents, 15+ book chapters, and gave more than 200 presentations at international conferences. Professor Gasser is amongst the highest-cited researchers in vascular biomechanics. He has taught numerous courses at undergraduate and graduate levels, served as supervisor for many engineering and clinical PhD students, is frequent member of examination and grading committees, and reviewer of several science councils as well as the most relevant scientific journals in the field.

Affiliations and Expertise

Professor, KTH Solid Mechanics, Stockholm, Sweden

Stéphane Avril

Stéphane Avril is a distinguished Full Professor at Institut Mines Telecom affiliated at Mines Saint-Etienne in France. Stéphane received his PhD in mechanical and civil engineering in 2002 at Mines Saint-Etienne (France). After positions at Arts et Métiers ParisTech (France) and Loughborough University (UK), Stéphane returned to his alma mater in 2008 and extended his experience of inverse problems to soft tissue biomechanics, especially regarding aortic aneurisms in close collaboration with vascular surgeons. Stéphane was a visiting Professor at Yale University between 2014 and 2019 and is currently a guest professor at TU Vienna and TU Graz in Austria. Stéphane has received many awards and distinctions including an ERC (European Research Council) consolidator grant for the Biolochanics project on: Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine. Most of Stéphane’s research is aimed at improving the treatment of cardiovascular diseases by assisting physicians and surgeons with biomechanical numerical simulations. In 2017, Stéphane co-founded Predisurge, a spin-off company of IMT at Mines Saint-Etienne. PrediSurge offers innovative software solutions for patient-specific numerical simulation of surgical procedures with first applications in endovascular aneurysm repair (EVAR).

Affiliations and Expertise

Full Professor, Institut Mines Telecom affiliated, Mines Saint-Etienne, France

John Elefteriades

John Elefteriades
John A. Elefteriades serves on multiple scientific advisory and editorial boards. He is a past President of the Connecticut Chapter of the American College of Cardiology and member of the national Board of Governors of the College. Dr. Elefteriades is also past President of the International College of Angiology. He serves on the editorial board of the American Journal of Cardiology, the Journal of Cardiac Surgery, Cardiology, and the Journal of Thoracic and Cardiovascular Surgery as well as being Editor-in-Chief of the journal AORTA. He has been a member of the Thoracic Surgery Director's Association and has been named consistently in The Best Doctors in America. He is a frequently requested international lecturer, visiting professor and guest surgeon. He is the author of over 400 scientific publications on a wide range of cardiac and thoracic topics. He was selected as one of the ten best doctors in America by Men’s Health magazine. He has been featured in many dozens of print, radio, and television presentations. He has received the Walter Bleifeld Memorial Award for Distinguished Contribution in Clinical Research in Cardiology and the John B. Chang Research Achievement Award. In 2005 he was selected to lecture at the Leadership in Biomedicine Series at the Yale University School of Medicine. In 2006, he received the Socrates Award from the Thoracic Residents Association, Thoracic Surgery Directors' Association, and the Society of Thoracic Surgeons, recognizing exceptional achievement in teaching and mentorship of residents. Dr. Elefteriades was named the William W.L. Glenn Professor of Cardiothoracic Surgery in 2006. This endowed chair honors the memory of Dr. Elefteriades’ mentor, Dr. Glenn. Dr. Elefteriades is the author of the books House Officer Guide to ICU Care (1st, 2nd, and 3rd Editions), Advanced Treatment Options for the Failling Left Ventricle, Your Heart: The Owner's Guide, Acute Aortic Disease, Extraordinary Hearts: A Journey of Cardiac Medicine and the Human Spirit, The Woman's Heart: An Owner's Guide, and the medical ethics thriller Transplant. In 2017, Dr. Elefteriades was awarded an Honorary Phd degree from the University of Liege (Belgium) in recognition of his work in diagnosis and treatment of aortic diseases. In 2020, Dr. Elefteriades was recognized by expertscape as the top aortic specialist in the world.

Affiliations and Expertise

William W.L. Glenn Professor of Surgery; Director, Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven Connecticut, USA

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