Biomechanics of Living Organs - 1st Edition - ISBN: 9780128040096, 9780128040607

Biomechanics of Living Organs

1st Edition

Hyperelastic Constitutive Laws for Finite Element Modeling

Authors: Yohan Payan Jacques Ohayon
eBook ISBN: 9780128040607
Hardcover ISBN: 9780128040096
Imprint: Academic Press
Published Date: 14th June 2017
Page Count: 602
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Biomechanics of Living Organs: Hyperelastic Constitutive Laws for Finite Element Modeling is the first book to cover finite element biomechanical modeling of each organ in the human body. This collection of chapters from the leaders in the field focuses on the constitutive laws for each organ.

Each author introduces the state-of-the-art concerning constitutive laws and then illustrates the implementation of such laws with Finite Element Modeling of these organs. The focus of each chapter is on instruction, careful derivation and presentation of formulae, and methods.

When modeling tissues, this book will help users determine modeling parameters and the variability for particular populations. Chapters highlight important experimental techniques needed to inform, motivate, and validate the choice of strain energy function or the constitutive model.

Remodeling, growth, and damage are all covered, as is the relationship of constitutive relationships of organs to tissue and molecular scale properties (as net organ behavior depends fundamentally on its sub components). This book is intended for professionals, academics, and students in tissue and continuum biomechanics.

Key Features

  • Covers hyper elastic frameworks for large tissue deformations
  • Considers which strain energy functions are the most appropriate to model the passive and active states of living tissue
  • Evaluates the physical meaning of proposed energy functions


Biomedical Engineers, Biomechanical Engineers, Graduate Students of Biomedical Engineering, Clinicians, Tissue Engineers

Table of Contents

Part 1: Constitutive laws for biological living tissues

Hyperelasticity Modeling for Incompressible Passive Biological Tissues

  1. Current Hyperelastic Models for Contractile Tissues: Application to Cardiovascular Mechanics
  2. Visco-hyperelastic strain energy function
  3. Constitutive Formulations for Soft Tissue Growth and Remodeling
  4. Strain energy function for damaged tissues
  5. Part 2: Passive soft organs

  6. Brain – Biomechanical modeling of brain soft tissues for medical applications
  7. Oesophagus – Modeling of esophageal structure and function in health and disease
  8. Aorta – Mechanical properties, histology, and biomechanical modeling
  9. Arteries & Coronaries Arterial – Wall Stiffness and Atherogenesis in Human Coronaries
  10. Breast – Clinical applications of breast biomechanics
  11. Liver – Non linear Biomechanical model of the Liver
  12. Abdomen – Mechanical modeling and clinical applications
  13. Small Intestine
  14. Bladder/prostate/rectum – Biomechanical Models of the Mobility of Pelvic Organs in the Context of Prostate Radiotherapy
  15. Uterus – Biomechanical modeling of uterus. Application to a childbirth simulation
  16. Skin – Skin mechanics
  17. Part 3: Active soft organs

  18. Skeletal muscle – Three-dimensional modeling of active muscle tissue: The why, the how, and the future
  19. Face – Computational modelling of the passive and active components of the face
  20. Tongue – Human tongue biomechanical modeling
  21. Upper airways – FRANK: a Hybrid 3D Biomechanical Model of the Head and Neck
  22. Heart – Adaptive reorientation of myofiber orientation in a model of biventricular cardiac mechanics: the effect of triaxial active stress, passive shear stiffness, and activation sequence
  23. Part 4: Musculo-skeletal models

  24. Spine – Relative contribution of structure and materials in the biomechanical behavior of the human spine
  25. Thigh – Modeling of the Thigh: a 3D deformable approach considering
    muscle interactions
  26. Calf – Subject-specific computational prediction of the effects of elastic compression in the calf

Foot – Biomechanical modeling of the foot


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About the Author

Yohan Payan

Yohan Payan leads the CAMI team (Computer Assisted Medical Interventions) of TIMC-IMAG Laboratory. With an engineering background, his main research interests concern the biomechanical modelling of soft tissues. He received the 2012 Senior Prize of the French Biomechanics Society. During the last fifteen years, he has co-supervised 25 PhD students, written close to 300 papers and edited two books focused on biomechanics for CAMI. During the same period, he spent two sabbatical years in Chile (Univ. of Santiago) and Canada (UBC, Vancouver) and was invited as a keynote speaker in more than twenty international conferences.

Affiliations and Expertise

TIMC-IMAG Laboratory, University of Grenoble, France

Jacques Ohayon

Jacques Ohayon received his MSc degree in Biomechanical Engineering at University of Compiègne (UTC) in France in 1982 and his PhD in Cardiac Mechanics in 1985 at the University of Paris 12 Val-de-Marne (UPVM). Since 2003, he performs his research at the Laboratory TIMC-CNRS UMR 5525 of Grenoble in the group Cellular/Tissular Dynamics and Functional Microscopy (DyCTiM). From 2006 to 2007 he was an invited senior scientist at the Laboratory of Integrative Cardiovascular Imaging Science at the NIH, USA. His current research interests are in biomechanics of atherosclerotic plaque, plaque detection, plaque rupture prediction, plaque growth and development of new clinical tools for imaging the elasticity of vulnerable plaque based on clinical OCT, MRI and IVUS sequences.

Affiliations and Expertise

TIMC-IMAG Laboratory, University of Savoie, France

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