Biomechanics of Coronary Atherosclerotic Plaque

Biomechanics of Coronary Atherosclerotic Plaque

From Model to Patient

1st Edition - March 15, 2020

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  • Editors: Jacques Ohayon, Gerard Finet, Roderic Pettigrew
  • eBook ISBN: 9780128171967
  • Paperback ISBN: 9780128171950
  • Hardcover ISBN: 9780323859332

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Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient, First Edition, is the first comprehensive text to focus on important biomechanical studies conducted in the last decade that have increased our understanding of coronary atherosclerotic plaque initiation, growth, and rupture, as well as improving the design of medical devices and clinical interventions, including surgical procedures. The book provides students, researchers, engineers, clinicians, and interventional cardiologists with an overview of the main topics related to the biomechanics of atherosclerosis, in a single volume written by several experts in the field. This volume is part of the Biomechanics of Living Organs book series. The biomechanics of human soft tissues and organs has been an emerging research field since the publication of Y.C. Fung’s original book series in the 1990s. The publication of such books entirely dedicated to a specific biomechanical subject is necessary to advance scientific research in the field of biomechanics and to transfer important knowledge to future generations. Therefore, this series of volumes on the biomechanics of living organs has been created. This series began in July 2017 with the publication of a first volume on the fundamentals of Hyperelastic Constitutive Laws for Finite Element Modeling of Living Organs. The current volume on the Biomechanics of Coronary Atherosclerotic Plaque, is the latest in this new series.

Key Features

  • Presents the main computational fluid dynamic studies performed, describing blood flow in healthy and pathological artery branches, including in coronary bifurcations
  • Highlights the correlation between plaque initiation regions and blood shear stress amplitude
  • Discusses the main biomechanical and mechanobiological models to highlight the importance of quantifying the residual and peak cap stresses and the presence of μ-calcifications to evaluate the risk of plaque rupture
  • Introduces the most recent intravascular imaging biomarker techniques (elastography, palpography and modulography)


Biomedical engineers, biomechanical engineers, graduate students of biomedical engineering, clinicians, tissue engineers

Table of Contents

  • Part 1: Biology, Physiopathology, Hemodynamics, Myogenic Response and Clinical Intravascular Imaging of the Coronary Vascular Wall
    1. Biomechanical Regulation of Endothelial Function in Atherosclerosis
    Catherine Demos, Ian Tamargo, Hanjoong Jo
    2. Molecular mechanisms of the vascular responses to hemodynamic forces
    Stephanie Lehoux
    3. Advanced atherosclerotic plaques in animal models versus human lesions: key elements to translation
    Emmanuelle Canet Soulas, Saami K. Yazdani
    4. Modeling the Glagov’s compensatory enlargement of human coronary atherosclerotic plaque
    Pak-Wing Fok, Navid Mohammad Mirzaei
    5. Measuring coronary arterial compliance and vasomotor response in clinical and research settings
    Allison G. Hays, Matthias Stuber, Erin Goerlich, Robert G. Weiss
    6. Coronary intravascular ultrasouind and optical coherence tomography imaging and clinical contexts in coronary hemodynamics
    François Derimay, Gilles Rioufol
    7. The interaction of biochemical, biomechanical and clinical factors of coronary disease: review and outlook
    T. Christian Gasser, Ulf Hedin, Joy Roy

    Part 2: Modeling Blood Flow in Arterial Branches and Bifurcations
    8. Local blood flow parameters and atherosclerosis in coronary artery bifurcations
    Antonios P. Antoniadis, Yiannis S. Chatzizisis
    9. Effect of regional analysis methods on assessing the association between wall shear stress and coronary artery disease progression in the clinical setting
    Lucas H. Timmins, Habib Samady, John Oshinski
    10. Hemodynamic disturbance due to serial stenosis in human coronary bifurcations: A computational fluid dynamics study
    Mauro Malve, Gerard Finet, Manuel Lagache, Ricardo Coppel, Roderic I. Pettigrew, Jacques Ohayon
    11. Hemodynamic perturbations due to the presence of stents
    Claudio Chiastra, Gabriele Dubini, Francesco Migliavacca
    12. A new reduced-order model to assess the true fractional flow reserve of a left main coronary artery stenosis with downstream lesions and collateral circulations: an in vitro study
    Manuel Lagache , Ricardo Coppel, Gerard Finet, Mauro Malve, Roderic I. Pettigrew, Jacques Ohayon

    Part 3: Fluid-Structure Interaction, Stress Distribution and Plaque Rupture in Arterial Wall
    13. In vitro, primarily microfluidic models for atherosclerosis
    Sarah E. Shelton, Roger D. Kamm
    14. Prediction of the coronary plaque growth and vulnerability change by using patient-specific 3D fluid-structure interaction models based on intravascular ultrasound and optical coherence tomography follow-up data
    Dalin Tang, Liang Wang, Xiaoya Guo, Akiko Maehara, David Molony, Habib Samady, Jie Zheng, Chun Yang, Jian Zhu, Genshan Ma, Haibo Jia, Kristen Billiar, Mitsuaki Matsumura, Gary S. Mintz, Don P. Giddens
    15. Atheromatous plaque initiation and growth: a multiphysical process explored by an in-silico mass transport model
    Myriam Cilla, Estefania Pena, Miguel-Angel Martinez
    16. Emergent biomechanical factors predicting vulnerable coronary atherosclerotic plaque rupture
    Estefania Pena, Myriam Cilla, Alvaro T. Latorreal, Miguel-Angel Martinez, Armida Gomez, Roderic I Pettigrew, Gerard Finet, Jacques Ohayon
    17. Microcalcifications and plaque rupture
    Luis Cardoso, Sheldon Weinbaum
    18. Identification of coronary plaque mechanical properties from ex-vivo testing
    Ali C. Akyildiz, Hilary E. Barrett, Frank J. H. Gijsen
    19. Importance of residual stress and basal tone in healthy and pathological human coronary arteries
    Jean-Louis Martiel, Gerard Finet, Gerhard A. Holzapfel, Matthias Stuber, Takeo Matsumoto, Roderic I. Pettigrew, Jacques Ohayon

    Part 4: Imaging Inflammatory Biomarkers for in vivo Intravascular Plaque Characterization
    20. Intravascular ultrasound imaging of human coronary atherosclerotic plaque: novel morpho-elastic biomarkers of instability
    Armida Gomez, Antoine Tacheau, Simon Le Floc’h, Roderic I. Pettigrew, Guy Cloutier, Gérard Finet, Jacques Ohayon
    21. Magnetic resonance elastography for arterial wall characterization
    Arunark Kolipaka, Richard D. White, Richard L. Ehman
    22. Noninvasive ultrafast ultrasound for imaging the coronary vasculature and assessing the arterial wall’s biomechanics
    Mathieu Pernot, Guillaume Goudot
    23. Pulse wave imaging for the mechanical assessment of atherosclerotic plaques
    Elisa E. Konofagou

    Part 5: Stenting, Coated Balloon, Drug Elution Systems and Modelling
    24. Structure-function relation in the coronary artery tree: Theory and applications in interventional cardiology
    François Derimay, Ghassan S. Kassab, Gerard Finet
    25. Sequential technique for the stenting of a coronary bifurcation: The re-proximal optimizing technique strategy
    François Derimay, Gilles Rioufol, Gerard Finet
    26. Modeling the stent deployment in coronary arteries and coronary bifurcations
    Claudio Chiastra, Gabriele Dubini, Francesco Migliavacca
    27. The coated balloon protocol: An emergent clinical technique
    Emily A. Turner, Claire Cawthon, William L. Pomeroy, Saami K. Yazdani
    28. Endovascular drug delivery and drug elution systems
    Farhad Rikhtegar Nezami, Lambros Athanasiou, Elazer R. Edelman

Product details

  • No. of pages: 686
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: March 15, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128171967
  • Paperback ISBN: 9780128171950
  • Hardcover ISBN: 9780323859332

About the Series Volume Editors

Jacques Ohayon

Jacques Ohayon received his MSc degree in Biomechanical Engineering at University of Compiègne (UTC) in France in 1982 and his PhD in Cardiac Mechanics in 1985 at the University of Paris 12 Val-de-Marne (UPVM). Since 2003, he performs his research at the Laboratory TIMC-CNRS UMR 5525 of Grenoble in the group Cellular/Tissular Dynamics and Functional Microscopy (DyCTiM). From 2006 to 2007 he was an invited senior scientist at the Laboratory of Integrative Cardiovascular Imaging Science at the NIH, USA. His current research interests are in biomechanics of atherosclerotic plaque, plaque detection, plaque rupture prediction, plaque growth and development of new clinical tools for imaging the elasticity of vulnerable plaque based on clinical OCT, MRI and IVUS sequences.

Affiliations and Expertise

Research, Cullular/Tissualr Dynamics and Functional Microscopy (DyCTiM), Laboratory TIMC-CNRS UMR 5525 of Grenoble, La Tronche, France

Gerard Finet

Gérard Finet is the Director of the Medical and interventional Cardiology Departments at the Cardiovascular Hospital Louis Pradel, Lyon, France. He received his MD in 1984 and his PhD in Biomedical Engineering and Intravascular Ultrasound Imaging in 1994 at the University Claude Bernard of Lyon, France. He joined the University of Lyon-1 in 1996 as a full Professor of Cardiology. The activities of Dr. Gérard Finet are dedicated to coronary IVUS imaging, coronary artery diseases and valvular diseases. In 1998, he was appointed head of the Interventional Cardiology Department at the Cardiovascular Hospital Louis Pradel. In 2000 he was an invited senior scientist at the Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC, USA. He is known internationally for his pioneering works performed at the University of Lyon, INSERM and Hospices Civils de Lyon on: 1) Multiple plaque ruptures in acute coronary syndrome, 2) Fractal nature of the coronary vascular trees, and 3) Sequential proximal optimizing technique in provisional coronary bifurcation stenting. He has published more than 170 peer-reviewed articles in these fields.

Affiliations and Expertise

Professor of Cardiology, University Claude Bernard of Lyon, France and Director of the Medical and Interventional Cardiology Departments at the Cardiovascular Hospital Louis Pradel, Lyon, France

Roderic Pettigrew

Roderic I. PETTIGREW is the CEO of the EnHealth and Executive Dean for EnMed at Texas A&M University and Houston Methodist Hospital. In 1977, Dr. Pettigrew received his Ph.D. in applied radiation physics from the Department of Nuclear Engineering at MIT. In 1979, he received his M.D. from the Leonard M. Miller School of Medicine, University of Miami. From 2002 to 2017, he was the founding Director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the NIH. Prior to his appointment at the NIH, Dr. Pettigrew was Professor of Radiology, Medicine (Cardiology) at Emory University in Atlanta, Georgia, Professor of Bioengineering at the Georgia Institute of Technology, and Director of the Emory Center for MR Research at the Emory University School of Medicine. He is known internationally for his pioneering work at Emory University involving four-dimensional imaging of the cardiovascular system using magnetic resonance (MRI). His current research focuses on integrated imaging and predictive modeling of coronary atherosclerotic disease. Dr. Pettigrew has been elected to membership in the US National Academy of Medicine, the National Academy of Engineering, and the National Academy of Inventors. He has also been elected a foreign member of the National Academy of Sciences, India. Other awards include Phi Beta Kappa, the Bennie Award for Achievement at Morehouse College, the Most Distinguished Alumnus of the University of Miami (1990), the Hall of Fame of the Miller School of Medicine, the Pritzker Distinguished Achievement Award of the Biomedical Engineering Society, the Distinguished Service Award of the National Medical Association, the Pierre Galletti Award of the American Institute of Medical and Biological Engineering, the Inaugural Gold Medal Award of the Academy of Radiology Research, the Distinguished Service Award of the International Society of Magnetic Resonance in Medicine, the Spirit of the Heart Award of the Association of Black Cardiologist, and the Gold Medal of the Radiological Society of North America (RSNA).

Affiliations and Expertise

Chief Executive Officer of Engineering Health (EnHealth) and executive Dean, Engineering Medicine (EnMed), Texas A&M and Houston Methodist Hospital, USA

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