Biomaterials Science

Biomaterials Science

An Introduction to Materials in Medicine

2nd Edition - July 29, 2004

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  • Authors: Buddy Ratner, Allan Hoffman, Frederick Schoen, Jack Lemons
  • eBook ISBN: 9780080470368

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The second edition of this bestselling title provides the most up-to-date comprehensive review of all aspects of biomaterials science by providing a balanced, insightful approach to learning biomaterials. This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials.

Key Features

  • Provides comprehensive coverage of principles and applications of all classes of biomaterials
  • Integrates concepts of biomaterials science and biological interactions with clinical science and societal issues including law, regulation, and ethics
  • Discusses successes and failures of biomaterials applications in clinical medicine and the future directions of the field
  • Cover the broad spectrum of biomaterial compositions including polymers, metals, ceramics, glasses, carbons, natural materials, and composites
  • Endorsed by the Society for Biomaterials


Biomaterials Engineers, Materials Scientists and Engineers, Clinical Enginners

Table of Contents

    PART I: Materials Science & Engineering
    Properties of Materials
    Bulk Properties of Materials
    Finite Element Analysis
    Surface Properties of Materials
    Role of Water in Biomaterials
    Classes of Materials Used in Medicine
    A Brief History of Silicone Biomaterials
    Bioresorbable and Biodegradable Materials
    Ceramics, Classes and Class-Ceramics
    Natural Materials
    Thin Films, Grafts, Coatings
    Medical Fibers and Biotextiles
    Biological Functional Materials
    Smart Materials
    Pyrolytic Carbon for Long-Term Medical Implants
    Textured and Porous Materials
    Non-fouling Surfaces
    PART II: Biology, Biochemistry and Medicine
    Background Concepts
    The Role of Absorbed Proteins in Tissue Response to Biomaterials
    Calls and Cell Injury
    Tissues: The Extracellular Matrix and Call-Biomaterials Interactions
    Mechanical Forces on Cells
    Host Reactions to Biomaterials and Their Evaluation
    Testing Biomaterials

    Inflammation, Wound Healing and the Foreign Body Response
    The Complement Systems
    Systemic Toxicity and Hypersensitivity
    Blood Coagulation and Blood-Materials Interactions
    Tumorigenesis and Biomaterials
    Testing Biomaterials
    In Vitro Assessment of Tissue Compatibility
    In Vivo Assessment of Tissue Compatibility
    Testing of Blood-Materials Interactions
    Large Animal Models in Cardiac and Vascular Biomaterials Research and Testing
    Microscopy for Biomaterials Science
    Degradation of Materials in the Biological Environment
    Degradation of Materials in the Biological Environment
    Degradative Effects of the Biological Environment on Metals and Ceramics
    Pathologic Calcification of Biomaterials
    Applications of Materials in Medicine, Dentistry and Biology
    Cardiovascular Medical Devices
    Nonthrombogenic Treatments and Strategies
    Dental Implantation
    Adhesive and Sealants
    Ophthalmologic Applications
    Intraocular Lens Implants: A Scientific Perspective
    Clinical Aspects of Orthopedic Biomaterial Performance
    Drug Delivery Systems
    Burn Dressings and Skin Substitutes
    Biomedical Sensors and Biosensors
    Diagnostics and Biomaterials
    Artificial Organs and Tissues
    Implantable Cardiac Assist Devices
    Extracorporeal Artificial Organs
    Cochlear Implants
    Artificial Red Blood Cell Substitutes
    Tissue Engineering
    Overview of Tissue Engineering
    Synthetic Bioresorbable Polymer Scaffolds
    PART III: Practical Aspects of Biomaterials
    Implants & Devices - Special Concerns
    Sterilization of Implants and Devices
    Implants and Device Failure
    Correlations of Materials Surface Properties with Biological Responses
    Implant Retrieval and Evaluation
    New Products and Standards
    Voluntary Consensus Standards
    Development and Regulation of Medical Products Using Biomaterials
    Ethical Issues in the Development of New Biomaterials
    Legal Aspects of Biomaterials
    Perspectives and Possibilities in Biomaterials Science

Product details

  • No. of pages: 864
  • Language: English
  • Copyright: © Academic Press 2004
  • Published: July 29, 2004
  • Imprint: Academic Press
  • eBook ISBN: 9780080470368

About the Authors

Buddy Ratner

Buddy D. Ratner, Michael L. and Myrna Darland Endowed Chair in Bioengineering and Professor of Chemical Engineering at the University of Washington, received his Ph.D. (1972) in polymer chemistry from the Polytechnic Institute of Brooklyn. From 1985-1996 he directed the NIH-funded National ESCA and Surface Analysis Center for Biomedical Problems (NESAC/BIO), and in 1996 he assumed the directorship of University of Washington Engineered Biomaterials (UWEB), an NSF Engineering Research Center. He is the editor of the Journal of Undergraduate Research in Bioengineering, a past president of the Society for Biomaterials and author of 400 scholarly works. Ratner is a fellow of the American Institute of Medical and Biological Engineering (AIMBE), the American Vacuum Society and a Fellow, Biomaterials Science and Engineering (FBSE). He served as president of AIMBE, 2002-2003. He is vice president of the Tissue Engineering Society International (TESI) 2003-2005. In 2002 Ratner was elected a member of the National Academy of Engineering, USA, and in 2004 he won the Founder’s Award for the Society For Biomaterials. His research interests include biomaterials, tissue engineering, polymers, biocompatibility, surface analysis of organic materials, self-assembly, nanobiotechnology and RF-plasma thin film deposition. Summary of Buddy Ratner’s awards and honors: 1989 Clemson Award for Contributions to the Biomaterials Literature 1990 Burlington Resources Foundation Faculty Achievement Award for Outstanding Research 1991 Perkin-Elmer Physical Electronics Award for Excellence in Surface Science 1991–1992 President, Society For Biomaterials 1993 Founding Fellow, American Institute of Medical and Biological Engineering (AIMBE) 1993 Fellow, American Vacuum Society; Vice President, AIMBE 1993 Fellow, Society For Biomaterials; Van Ness Lecturer, Rensselaer Polytechnic Institute 1998 C.M.A. Stine Award in Materials Science (AIChE); American Vacuu

Affiliations and Expertise

Professor of Chemical Engineering and Bioengineering, University of Washington, USA

Allan Hoffman

Allan Hoffman
Professor Hoffman studied at M.I.T., where he received B.S., M.S., and Sc.D. degrees in Chemical Engineering between 1953 and 1957. He taught on the faculty of M.I.T. Chemical Engineering Department for a total of ten years. He also spent four years in industry. Since 1970 he has been Professor of Bioengineering at the University of Washington in Seattle, Washington. Professor Hoffman has over 330 publications, several books and chapters, 21 patents and several other patents pending. He is on the Editorial Boards of seven scientific journals. Summary of professional activities and awards include: •President, Society for Biomaterials, 1983-1984 •Clemson Award in Biomaterials, 1984 •Board of Governors, Controlled Release Society, 1991-1994 •Biomaterials Science Prize, Japanese Biomaterials Society, 1990 •Founders’ Award of the Society for Biomaterials, 2000 •Election to the National Academy of Engineering, 2005 In December, 1992, Hoffman's colleagues organized a symposium in Maui, Hawaii in honor of his 60th birthday. In December, 2002 his 70th birthday was celebrated at another special symposium, once again in Maui, Hawaii. Papers from the first symposium were published in the Journal of Biomaterials Science (Polymer Edition), along with a Festschrift book, and similar publications are in press at this time from the second symposium.

Affiliations and Expertise

Professor of Bioengineering, University of Washington, USA

Frederick Schoen

Frederick J. Schoen is Professor of Pathology and Health Sciences and Technology, Harvard Medical School; Director of Cardiac Pathology and Executive Vice-Chairman in the Department of Pathology at the Brigham and Women's Hospital (BWH) in Boston. Schoen received a B.S.E. (Materials and Metallurgical Engineering) from the University of Michigan (1966), a Ph.D. in Materials Science from Cornell University (1970) and an M.D. from the University of Miami School of Medicine (1974). Following a Surgery internship followed by residency in Anatomic Pathology and fellowship in Thoracic and Cardiovascular Pathology at the University of Florida, he joined BWH in 1980. Schoen has focused his research career on tissue-biomaterial interactions, structure-function-pathology correlations in the native heart valves, heart valve substitutes and other cardiovascular prostheses, calcification of bioprosthetic tissues, heart transplantation, and cardiovascular applications of tissue engineering. Schoen has leadership responsibilities in academic programs in the Department of Pathology, Harvard Medical School and the Harvard-MIT Division of Health Sciences and Technology (HST); he currently chairs the HST Faculty Appointments Committee and the Graduate (Curriculum) Committee, and is an active teacher of courses in pathology, cardiovascular pathology, and biomaterials and tissue engineering. He chairs the BWH Education Committee. Schoen is author or co-author of approximately 375 manuscripts in journals and books. He authored Interventional and Surgical Cardiovascular Pathology: Clinical Correlations and Basic Principles (1989); and was Co-Editor of Biomaterials Science: An Introduction to Materials in Medicine (1st Edition 1996, 2nd Edition 2004), and Silver’s Cardiovascular Pathology, 3rd Edition (2001). He is Past-President of the Society For Biomaterials (SFB) and the Society for Cardiovascular Pathology, and was Founding Fellow of the American In

Affiliations and Expertise

Professor of Pathology and Health Sciences and Technology, Harvard Medical School, USA

Jack Lemons

Affiliations and Expertise

Professor and Director of Biomaterials Laboratory Surgical Research, University of Alabama, USA

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