Biomaterials for Spinal Surgery - 1st Edition - ISBN: 9781845699864, 9780857096197

Biomaterials for Spinal Surgery

1st Edition

Editors: Luigi Ambrosio Elizabeth Tanner
eBook ISBN: 9780857096197
Hardcover ISBN: 9781845699864
Imprint: Woodhead Publishing
Published Date: 12th March 2012
Page Count: 640
Tax/VAT will be calculated at check-out
300.00
185.00
230.00
Unavailable
File Compatibility per Device

PDF, EPUB, VSB (Vital Source):
PC, Apple Mac, iPhone, iPad, Android mobile devices.

Mobi:
Amazon Kindle eReader.

Institutional Access


Table of Contents

Contributor contact details

Chapter 1: Introduction to biomaterials for spinal surgery

Abstract:

1.1 Introduction

1.2 Total disc replacement

1.3 Nucleus pulposus replacement

1.4 Materials for spinal applications

1.5 Conclusions

Part I: Fundamentals of biomaterials for spinal surgery

Chapter 2: An overview of the challenges of bringing a medical device for the spine to the market

Abstract:

2.1 Introduction

2.2 Selection and sourcing of materials in medical device developments

2.3 Biocompatibility testing

2.4 Medical device regulation

2.5 Conclusions

2.6 Acknowledgement

Chapter 3: Introduction to spinal pathologies and clinical problems of the spine

Abstract:

3.1 Introduction

3.2 Degenerative spine disease

3.3 Spinal trauma

3.4 Spinal deformity

3.5 Malignancy

3.6 Infection

3.7 Conclusions

Chapter 4: Forces on the spine

Abstract:

4.1 Introduction

4.2 In vivo measured components of spinal loads

4.3 In vitro measured spinal load components

4.4 Analytical models for spinal load estimation

4.5 Recommendations for the simulations of loads for in vitro and numerical studies

4.6 Conclusions

Chapter 5: Finite element modelling of the spine

Abstract:

5.1 Introduction

5.2 Functional spine biomechanics and strength of numerical explorations

5.3 Geometrical approximations in spine finite element modelling

5.4 Numerical approximations: accuracy and computational cost

5.5 Constitutive models for the spine tissues

5.6 Simulating the mechanical loads on the spine

5.7 Model verifications and interpretations: the validation concept and quantitative validation

5.8 Future trends and conclusions: the virtual physiological spine

Chapter 6: Osteobiologic agents in spine surgery

Abstract:

6.1 Introduction

6.2 Bone formation and healing

6.3 Osteobiologics for spine fusion

6.4 Bone growth factors

6.5 Cellular biologics

6.6 Conclusions

Part II: Spinal fusion and intervertebral discs

Chapter 7: Spine fusion: cages, plates and bone substitutes

Abstract:

7.1 Introduction

7.2 Spine fusion: historical concerns and surgical skills

7.3 Bone substitutes in spine fusion

7.4 Bone growth factors

7.5 Autologous bone marrow

7.6 Future trends

Chapter 8: Artificial intervertebral discs

Abstract:

8.1 Introduction

8.2 Structure and function of the intervertebral disc

8.3 The artificial intervertebral disc: design and materials

8.4 Fibre-reinforced composite materials: basic principles

8.5 Composite biomimetic artificial intervertebral discs

8.6 Future trends and conclusions

Chapter 9: Biological response to artificial discs

Abstract:

9.1 Introduction

9.2 The healing response to intervertebral disc implants

9.3 Infection as a cause of failure of implants

9.4 Loosening and the reaction to the products of wear and corrosion

9.5 Carcinogenicity and genotoxicity of metal implants

9.6 Conclusions

Part III: Vertebroplasty and scoliosis surgery

Chapter 10: The use of polymethyl methacrylate (PMMA) in neurosurgery

Abstract:

10.1 Introduction: a history of polymethyl methacrylate (PMMA)

10.2 Characteristics of polymethyl methacrylate (PMMA)

10.3 Preparation of polymethyl methacrylate (PMMA) for use in clinical practice

10.4 Clinical use of polymethyl methacrylate (PMMA) in neurosurgery

10.5 Developments in polymethyl methacrylate (PMMA)

10.6 Conclusions

Chapter 11: Optimising the properties of injectable materials for vertebroplasty and kyphoplasty

Abstract:

11.1 Introduction

11.2 Polymethyl methacrylate (PMMA) based bone cements

11.3 Calcium phosphate and calcium sulfate based bone cements

11.4 Conclusions

Chapter 12: Injectable calcium phosphates for vertebral augmentation

Abstract:

12.1 Introduction

12.2 Polymethyl methacrylate (PMMA)

12.3 Calcium phosphate cements

12.4 Conclusions

Chapter 13: Composite injectable materials for vertebroplasty

Abstract:

13.1 Introduction: a background on the use of composites in vertebroplasty

13.2 Properties of composites for vertebroplasty

13.3 Further development in composite injectable materials

13.4 Conclusions

Chapter 14: Scoliosis implants: surgical requirements

Abstract:

14.1 Introduction

14.2 Definition of scoliosis

14.3 Management of scoliosis

14.4 General principles for spinal fusion

14.5 Outcomes in scoliosis surgery

14.6 Future development of biomechanical implants

14.7 Conclusions

14.8 Sources of further information

Chapter 15: Shape memory, superelastic and low Young’s modulus alloys

Abstract:

15.1 Introduction

15.2 Fundamental characteristics of shape memory and superelastic alloys

15.3 Low Young’s modulus alloys

15.4 Metals required for spinal surgery

15.5 Conclusions

15.6 Acknowledgements

Part IV: Regenerative medicine in the spine

Chapter 16: Cell-based tissue engineering approaches for disc regeneration

Abstract:

16.1 Introduction

16.2 Rationale behind the use of cells

16.3 Choice of cell type (not including mesenchymal stem cells)

16.4 Current issues to be addressed

16.5 Future trends and conclusions

16.6 Sources of further information

Chapter 17: Angiogenesis control in spine regeneration

Abstract:

17.1 Introduction

17.2 The role and the mechanisms of angiogenesis

17.3 Physiological and pathological vascularisation of different intervertebral disc (IVD) histological compartments

17.4 Strategies to promote angiogenesis in tissue regeneration

17.5 Angiogenesis inhibition in intervertebral disc (IVD) regeneration and other clinical applications

17.6 Future trends

17.7 Sources of further information

17.8 Acknowledgements

Chapter 18: Stem cells for disc regeneration

Abstract:

18.1 Introduction

18.2 Tissue engineering solutions for intervertebral disc (IVD) disease

18.3 Mesenchymal stem cells (MSC) and regeneration of the intervertebral disc (IVD)

18.4 Regeneration of the annulus

18.5 Use of scaffolds with mesenchymal stem cells (MSC) for intervertebral disc (IVD) regeneration

18.6 Future trends

18.7 Conclusions

Chapter 19: Nucleus regeneration

Abstract:

19.1 Introduction

19.2 The intervertebral disc: anatomy, structure and function

19.3 Mechanics–biology interrelation

19.4 Annulus, nucleus and entire intervertebral disc: the tissue engineering approach

19.5 Conclusions

Chapter 20: In vivo models of regenerative medicine in the spine

Abstract:

20.1 Introduction

20.2 Selecting an animal model

20.3 Intervertebral spinal fusion

20.4 Degenerative disc disease

20.5 Future trends and conclusions

20.6 Acknowledgements

Index


Description

There have been important developments in materials and therapies for the treatment of spinal conditions. Biomaterials for spinal surgery summarises this research and how it is being applied for the benefit of patients.

After an introduction to the subject, part one reviews fundamental issues such as spinal conditions and their pathologies, spinal loads, modelling and osteobiologic agents in spinal surgery. Part two discusses the use of bone substitutes and artificial intervertebral discs whilst part three covers topics such as the use of injectable biomaterials like calcium phosphate for vertebroplasty and kyphoplasty as well as scoliosis implants. The final part of the book summarises developments in regenerative therapies such as the use of stem cells for intervertebral disc regeneration.

With its distinguished editors and international team of contributors, Biomaterials for spinal surgery is a standard reference for both those developing new biomaterials and therapies for spinal surgery and those using them in clinical practice.

Key Features

  • Summarises recent developments in materials and therapies for the treatment of spinal conditions and examines how it is being applied for the benefit of patients
  • Reviews fundamental issues such as spinal conditions and their pathologies, spinal loads, modelling and osteobiologic agents in spinal surgery
  • Discusses the use of bone substitutes and artificial intervertebral discs and covers topics such as the use of injectable biomaterials like calcium phosphate for vertebroplasty and kyphoplasty

Readership

Materials scientists and engineers in industry, biologists and clinicians, biomaterials academics and orthopedic surgeons.


Details

No. of pages:
640
Language:
English
Copyright:
© Woodhead Publishing 2012
Published:
Imprint:
Woodhead Publishing
eBook ISBN:
9780857096197
Hardcover ISBN:
9781845699864

Reviews

This is a good reference on biomaterials. It will be of most interest to materials engineers, bioengineers and spine surgeons. It is well written and provides an extensive list of references., Doody's Book Reviews


About the Editors

Luigi Ambrosio Editor

Luigi Ambrosio received the doctoral degree in Chemical Engineering (1982) from the University of Naples "Federico II'. He was a Research Associate at the University of Naples (1983-1985), Research Associate at University of Connecticut, USA (1985-1986), and Visiting Scientist at Kontron Medical Inc., USA (1985- 1988). From 1989 he was appointed at the Institute of Composite and Biomedical Materials, CNR, as Research Scientist (1989-2002), Senior Research Scientist (2002-2003) and Research Director (2003-today). From September 1997 to 2004 he was Adjunct Professor in Biomaterials at the University of Connecticut, USA and Treasurer of the European Society for Biomaterials (ESB). He is a member of the Advisory Board and Guest Editor of International and National Scientific Journals, Council Member of the European Society for Biomaterials (ESB), Vice-President of the Italian Society of Biomaterials (SIB), President of the Interdisciplinary Biomaterials Group of the Italian Chemical Society and Past-President of the European Society for Biomaterials (ESB). He has been nominated as a Fellow of the American Institute for Medical and Biological Engineering (March 2001), and Fellow of Biomaterials Science and Engineering (May 2004).

Affiliations and Expertise

Director, Institute for Composite and Biomedical Materials, National Research Council, Adjunct Professor, Biomaterials, University of Naples "Federico II'

Elizabeth Tanner Editor

Elizabeth Tanner is Professor of Mechanics of Materials and Structures at the University of Glasgow, UK. Both are noted for their research in bone biomaterials and therapies.

Affiliations and Expertise

University of Glasgow, UK