Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling

1st Edition - August 20, 2020

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  • Editors: Subhas Kundu, Rui Reis
  • Paperback ISBN: 9780128181287
  • eBook ISBN: 9780128181294

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Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine.

Key Features

  • Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles
  • Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types
  • Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery


Materials Scientists, those working in Regenerative Medicine, those working in Biochemistry, those working in drug delivery, academics and those working in the clinic

Table of Contents

  • 1. Trends in biomaterials for 3D cancer modeling
    2. Causes of cancers: physical, chemical, biological carcinogens and viruses
    3. Three-dimensional in vitro models of angiogenesis
    4. Metastasis in 3D biomaterials
    5. Biomatrices that mimic the cancer extracellular environment
    6. Marine derived biomaterials for cancer treatment
    7. 3D scaffold materials for skin cancer modeling
    8. Three-dimensional tumor model and their implication in drug screening for tackling chemoresistance
    9. In vitro 3D modelling for prostate cancer
    10. Biomaterial based in vitro models for pancreatic cancer
    11. Mesoporous silica nanoparticles for cancer theranostics applications
    12. Microfluidic systems in cancer research
    13. Bio-detection and sensing for cancer diagnostics
    14. Biomaterials as ECM-like matrices for 3D in vitro tumor models
    15. 3D cancer spheroids and microtissues
    16. Co-culture and 3D tumor models for drug and gene therapy testing
    17. Engineering of 3D in vitro models for cancer research
    18. Tissue engineered 3D cancer microenvironment for screening therapeutics
    19. 3D neuroblastoma models using engineered cell-derived matrices
    20. 3D cancer models for chemotherapy using biomaterials
    21. 3D tumor-on-chip devices with perfusion for anti-cancer drug testing
    22. A predictive oncology framework: Modelling tumor proliferation using a FEM platform
    23. Understanding the impact of controlled oxygen delivery to 3D cancer cell culture
    24. 3D full skin models for skin cancer research
    25. Tissue engineering strategies for treatment of skeletal maxillofacial defects resulting from neoplasms resections
    26. 3D culture systems as models for solid tumors and cancer metabolism
    27. Biofabrication of 3D tumor models in cancer research
    28. Engineering breast cancer models in vitro with 3D printing

Product details

  • No. of pages: 772
  • Language: English
  • Copyright: © Elsevier 2020
  • Published: August 20, 2020
  • Imprint: Elsevier
  • Paperback ISBN: 9780128181287
  • eBook ISBN: 9780128181294

About the Editors

Subhas Kundu

Prof. Subhas C. Kundu is a European Research Area Chair and Professor at the 3B´s Research Group, I3Bs – Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho (Portugal). Earlier Prof. Kundu was a Professor in the Department of Biotechnology at the Indian Institute of Technology Kharagpur (India). He obtained his post-graduation and PhD in Genetics from Banaras Hindu University (India) and received his post-doctoral trainings at the Institute of Molecular Biology in Moscow, the York University in Canada, the Medical University in Lubeck (Germany), and the Brunel University in UK. His research interests include silk biomaterial matrices for biomedical applications including 3D cancer modelling for investigating tumor growth and progression. His present area of interest is the use of natural-based biomaterials for 3D cancer modelling and drug screening.

Affiliations and Expertise

European Research Area Chair and Professor, 3B´s Research Group, I3Bs – Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Portugal

Rui Reis

Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.

Affiliations and Expertise

Director and Professor, 3B´s Research Group, I3Bs – Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Portugal

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