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Biomaterials for 3D Tumor Modeling - 1st Edition - ISBN: 9780128181287

Biomaterials for 3D Tumor Modeling

1st Edition

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Editors: Subhas Kundu Rui Reis
Paperback ISBN: 9780128181287
Imprint: Elsevier
Published Date: 28th August 2020
Page Count: 772
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Table of Contents

1. Trends in biomaterials for 3D cancer modeling
2. Causes of cancers: physical, chemical, biological carcinogens and viruses
3. Three-dimensional in vitro models of angiogenesis
4. Metastasis in 3D biomaterials
5. Biomatrices that mimic the cancer extracellular environment
6. Marine derived biomaterials for cancer treatment
7. 3D scaffold materials for skin cancer modeling
8. Three-dimensional tumor model and their implication in drug screening for tackling chemoresistance
9. In vitro 3D modelling for prostate cancer
10. Biomaterial based in vitro models for pancreatic cancer
11. Mesoporous silica nanoparticles for cancer theranostics applications
12. Microfluidic systems in cancer research
13. Bio-detection and sensing for cancer diagnostics
14. Biomaterials as ECM-like matrices for 3D in vitro tumor models
15. 3D cancer spheroids and microtissues
16. Co-culture and 3D tumor models for drug and gene therapy testing
17. Engineering of 3D in vitro models for cancer research
18. Tissue engineered 3D cancer microenvironment for screening therapeutics
19. 3D neuroblastoma models using engineered cell-derived matrices
20. 3D cancer models for chemotherapy using biomaterials
21. 3D tumor-on-chip devices with perfusion for anti-cancer drug testing
22. A predictive oncology framework: Modelling tumor proliferation using a FEM platform
23. Understanding the impact of controlled oxygen delivery to 3D cancer cell culture
24. 3D full skin models for skin cancer research
25. Tissue engineering strategies for treatment of skeletal maxillofacial defects resulting from neoplasms resections
26. 3D culture systems as models for solid tumors and cancer metabolism
27. Biofabrication of 3D tumor models in cancer research
28. Engineering breast cancer models in vitro with 3D printing


Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer.

This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine.

Key Features

  • Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles
  • Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types
  • Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery


Materials Scientists, those working in Regenerative Medicine, those working in Biochemistry, those working in drug delivery, academics and those working in the clinic


No. of pages:
© Elsevier 2020
28th August 2020
Paperback ISBN:

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About the Editors

Subhas Kundu

S. C. Kundu, Ph. D. is now European Research Area Chair and Full Professor at 3Bs Research Group, I3Bs-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Tissue Engineering and Regenerative Medicine, Portugal under European Commission Programme (FoReCaST). Before joining 3Bs Research Group, he was a Full Professor and Founder Head of Department of Biotechnology of Indian Institute of Technology (IIT) Kharagpur, India. In his early career, he was Assistant Professor to Full Professor including Head of Department at Manipur University (erstwhile Jawaharlal Nehru University Centre), Imphal, Manipur. He was also a Distinguished Invited Professor at Dankook University, South Korea. He taught genetics, cell and molecular biology and recombinant DNA technology to under-graduates, post-graduates and pre-doctoral students. Dr. Kundu received his post-doctoral training at Institute of Molecular Biology, Moscow; Department of Biology, York University, Canada; Medical University, Lubeck, Germany; Department of Biology & Biochemistry, Brunel University, UK. His chief area of interest is silk biomaterials, tissue engineering and 3D cancer modelling for drug screening. He has published 180 major research articles in journals such as Chromosoma, Experimental Cell Research, Methods in Enzymology, J Biological Chemistry, Biotechnology and Bioengineering, Acta Biomaterialia, Biomedical Microdevices, Biomaterials, Progress in Polymer Science, Biotechnology Advances, Tissue Engineering A, Nanoscale, Advanced Materials, Advanced Functional Materials, and others. He is in the editorial board member of Biomaterials, Scientific Reports, Journal of Biological Engineering, and Journal of Biomedical Materials. He is a Fellow of the National Academy of Sciences, India, West Bengal Academy of Sciences, India and Alexander von Humboldt, Germany.

Affiliations and Expertise

European Research Area Chair and Full Professor, 3Bs Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, 4805-017 Barco, Guimarães, Portugal.

Rui Reis

Professor Rui L. Reis, PhD, DSc, Hon. Causa MD, Hon Causa PhD, FBSE, FTERM. He’s Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited several books and has more 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.

Affiliations and Expertise

Director and Professor, 3B´s Research Group, I3Bs – Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Portugal