Biomaterials for 3D Tumor Modeling

1. Introduction: Biomaterials for 3D cancer cell culture models
   2. Causes of cancers: physical, chemical, biological carcinogens and viruses
   3. Existing in vitro and in vivo cancer models
   4. Angiogenesis during tumor progression
   5. Inflammation and cancer progression
   6. Metastasis in 3D biomaterials
   7. 3D tumor organoids
   8. Engineering 3D hydrogels for personalized in vitro human tissue models
   9. 3D culture system of solid tumors and cancer metabolism
   10. 3D matrices and surface architecture for cancer research
   11. 3D (bio) printing of tumor models
   12. E-spun 3D materials for cancer modelling
   13. 3D scaffold materials for skin cancer
   14. 3D models and efficacy of drugs and chemicals
   15. Synthetic biomaterials 3D cancer model
   16. Silica nanoparticles as theranostics cancer treatment
   17. In silico 3D cancer modelling
   18. Cancer immunotherapy
   19. 3D lung cancer tissue model
   20. 3D liver cancer disease model
   21. 3D oral cancer model for tackling drug resistance
   22. In vitro 3D modelling for prostate cancer 23. Pancreatic cancer organoids
   24. Pediatric 3D cancer model
   25. In vitro 3D ovarian cancer therapy
   26. Bio-glass and 3D bone cancer model
   27. Nanoparticles as cancer therapeutic carriers
   28. Tumor angiogenesis using 3D biomaterials
   29. Industrial applications of tumor-on-a-chip
   30. Microfluidic systems in cancer research
   31. Biomaterial based anticancer drug delivery
   32. Bio-detection/biosensor and diagnostics for cancer diseases
   33. Living cancer cell imaging
   34. 3D preclinical cancer models

2D cell culture models are utilized in order to develop an understanding of cancer and to develop potential treatments. However there are many limitations to 2D models, mainly that they do not correctly capture the full picture of a 3D biological system, its architecture and microenvironments. 3D culture models have the potential to provide more accurate pictures of these systems and replicate the complexity and hierarchical organization of natural ECM of tumor cells.

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects.

The book reviews advanced fundamental topics including causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are discussed including lung, liver, oral, prostate, pancreatic, ovarian, bone and paediatric cancer.

Biomaterials for 3D Tumor Modeling is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery, and regenerative medicine.

• Reviews key biomaterials topics including synthetic biomaterials, hydrogels, e-spun materials, nanoparticles, including materials design and processing concepts
• Provides comprehensive overview of 3D cancer models for key biological systems and cancer types
• Includes overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Material Scientists, those working in Regenerative Medicine, those working in Biochemistry, those working in drug delivery, academics and those working in the clinic