Biomarkers of Hip Implant Function

Biomarkers of Hip Implant Function

1st Edition - October 1, 2022

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  • Editor: Ilona Swiatkowska
  • Paperback ISBN: 9780128215968

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Description

Biomarkers of Hip Implant Function brings together established and potential new biomarkers, critically evaluating their clinical usefulness based on recent evidence. Researchers will benefit from a comprehensive view of the topic to identify underexplored areas. Orthopedic surgeons and general practitioners will use the book to monitor implant performance and facilitate management of their patients. Additionally, the work will benefit engineers and joint implant manufacturers to guide improvements in design. This book will also be of interest to regulators and policymakers by helping them update their guidelines on follow-ups for hip implant recipients. Nearly all orthopedic surgeons have implanted a cobalt-chromium hip and most general practitioners have at least one patient with cobalt-chromium implant on their books. The recent worldwide controversy surrounding metal-on-metal hips means that advice on how to manage patients with these implants is of great interest to these professionals. Hence, this book is a welcomed addition to the conversation.

Key Features

  • Covers all candidate biomarkers of hip implant wear and toxicity in a single source
  • Summarizes recent research into blood titanium levels associated with well-functioning and malfunctioning hip implants to aid implant revision decisions
  • Contains essential clinical cases and tables to illustrate points

Readership

Researchers with crossover for clinicians; orthopaedic surgeons and general practitioners; engineers and joint implant manufacturers; regulators and policy influencers, such as the FDA and the UK's Medicines and Healthcare products Regulatory Agency (MHRA)

Table of Contents

  • Part I: Foundational information

    Chapter 1. Hip arthroplasty and implant materials

    Chapter 2. Degradation of metal hip implants

    Chapter 3. Implant metals and their potential toxicity

    Part II: Assessing hip implant function and risk of local and systemic adverse reactions

    Chapter 4. Markers of hip implant degradation: analytical considerations and clinical interpretation

    Chapter 5. Biomarkers of compromised implant fixation

    Chapter 6. Biomarkers of periprosthetic joint infection

    Chapter 7. Hip implants and systemic cobalt toxicity: a comprehensive review with case studies

    Part III: Translational effect of biomarker research on clinical practice

    Chapter 8. Clinical guidelines on the use of biomarkers for surveillance of hip replacements

Product details

  • No. of pages: 200
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: October 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128215968

About the Editor

Ilona Swiatkowska

Ilona Świątkowska is an experienced researcher and editor who received her doctorate from University College London. Her academic work has centred around the local and systemic adverse effects of cobalt, chromium, and titanium in the setting of hip arthroplasty. The project was supervised by Professor Alister Hart of the Royal National Orthopaedic Hospital (Stanmore, United Kingdom), whose research into blood cobalt and chromium levels in recipients of hip replacements directly influenced the current MHRA guidelines concerning the follow-up of patients with metal-on-metal hips. Ilona has published a comprehensive review on titanium as a biomarker of implant wear and defined updated laboratory reference ranges for blood and plasma titanium concentrations associated with well-functioning titanium-based hip implants.

Affiliations and Expertise

University College London, United Kingdom

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