Biological Research on Addiction examines the neurobiological mechanisms of drug use and drug addiction, describing how the brain responds to addictive substances as well as how it is affected by drugs of abuse. The book's four main sections examine behavioral and molecular biology; neuroscience; genetics; and neuroimaging and neuropharmacology as they relate to the addictive process.

This volume is especially effective in presenting current knowledge on the key neurobiological and genetic elements in an individual’s susceptibility to drug dependence, as well as the processes by which some individuals proceed from casual drug use to drug dependence.

Biological Research on Addiction is one of three volumes comprising the 2,500-page series, Comprehensive Addictive Behaviors and Disorders. This series provides the most complete collection of current knowledge on addictive behaviors and disorders to date. In short, it is the definitive reference work on addictions.

Key Features

  • Each article provides glossary, full references, suggested readings, and a list of web resources
  • Edited and authored by the leaders in the field around the globe – the broadest, most expert coverage available
  • Discusses the genetic basis of addiction
  • Covers basic science research from a variety of animal studies


Researchers and students in psychology, psychiatry, neuroscience and neurology

Table of Contents


Scope and Format

Volume 2: Biological Research on Addiction

Editors: Biographies

List of Contributors

Section I: Behavioral Biology, Preclinical Animal Studies of Addiction

Chapter 1. Neurobiological Mechanisms of Drug Addiction: An Introduction

Conceptual Framework for Neurobiology of Addiction

Neurobiology of the Binge/Intoxication Stage

Neurobiology of the Withdrawal/Negative Affect Stage

Neurobiology of the Preoccupation/Anticipation Stage

Molecular and Cellular Targets within the Brain Circuits Associated with Addiction

Brain Imaging Circuits Involved in Human Addiction



See also


Further Reading

Chapter 2. Mice and Alcohol


Drinking Studies

Operant Oral Self-Administration

Conditioned Taste Aversion and Conditioned Place Preference

Motor Behavior

Alcohol Withdrawal and Dependence

Anxiety and Novelty Seeking


Further Reading

Chapter 3. Alcohol and Rats


Drinking Studies

Conditioned Place Preference

Conditioned Taste Aversion

Sensitivity to Alcohol and Tolerance/Sensitization Phenomenon

Alcohol Dependence, Withdrawal, Operant Oral Self-Administration, and Relapse


See also

Further Reading

Relevant Websites

Chapter 4. Nonhuman Primate Models of Alcohol Abuse and Alcoholism


Use of Nonhuman Primates in Alcohol Research

Pharmacological Models

Behavioral Models



See also


Further Reading

Chapter 5. Zebrafish and Alcohol

Alcohol-Related Human Diseases Represent a Large Unmet Medical Need

Animal Models and Their Role in Alcohol Re


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© 2013
Academic Press
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"The book considers the neurobiological mechanisms of drug use and drug addiction as well as the animal models developed to gain this knowledge…This volume provides an in-depth, detailed review of the wide range of literature on the key neurobiological and genetic elements involved in the development of addictions. This is an exceptional comprehensive reference." Rating: 4, January 24, 2014
"Miller aims to improve the lives of addicts and their families through a comprehensive and detailed understanding of the addictive process, while providing a science-based approach to the study, prevention and treatment of addictions… It targets advanced undergraduates, graduates, and postdoc students, professors, researchers, clinicians, and policymakers."--Reference & Research Book News, December 2013