Biological Oxidation Systems V2

1st Edition - January 1, 1990
Editor: C.C. Reddy
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 5 1 5 - 2

Biological Oxidation Systems, Volume II discusses the various antioxidants and antioxidant enzymes that play significant roles in protecting cells from deleterious reactions… Read more

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Biological Oxidation Systems, Volume II discusses the various antioxidants and antioxidant enzymes that play significant roles in protecting cells from deleterious reactions between their structural/functional components and the free radicals. This book examines the myriad chemical reactions of a cell’s metabolic activity that produce a variety of free radicals. Comprised of three parts encompassing 35 chapters, this volume starts with an overview of the metabolism of xenobiotics during arachidonic acid metabolism. This book then discusses the various causes of human cancers and diseases, which include exposure to environmental chemicals and other toxicants. This text considers the dietary habits and nutritional factors that play an important role in the causation and development of several human cancers, including cancer of the breast, colon, prostate, and other organs. Other chapters discuss the toxic effects of several xenobiotics that involve free-radical mechanisms. Biochemists, biophysicists, microbiologists, organic chemists, food chemists, and medical scientists will find this book extremely useful.

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Foreword

Preface

VI. Oxidation Mechanisms in Carcinogenesis

Oxidations Catalyzed by Prostaglandin H Synthase

Oxidation Reactions by Endoperoxide Synthase

Molecular Mechanisms for the Peroxidase Catalyzed Activation of Arylamine Carcinogens to Cytotoxic Metabolites

Inhibitors of Carcinogenesis

The Role of Iron in Asbestos-Catalyzed Damage to Lipids and DNA

Selective Enhancement of Free Radicals by cis-Unsaturated Fatty Acids in Tumor Cells as a Strategy to Kill Tumor Cells In Vitro and In Vivo

Inhibition of Binding of Aflatoxin Β1 to Renal DNA by Dehydroepiandrosterone

VII. Enzymes in Prostaglandin and Leukotriene Metabolism

Prostaglandin H Synthase

Peroxide Tone and Its Consequences

Involvement of Glutathione Peroxidases in Prostaglandin Biosynthesis

Non-Cyclooxygenase Prostaglandin Biosynthesis: Formation of PGA3 Isomers Via an Allene Oxide

Non-Cyclooxygenase Oxidative Formation of a Series of Novel Prostaglandins: Ramifications for the Measurement of Eicosanoids in Biological Fluids

Lipoxins: Bioactive Eicosanoids Generated by Lipoxygenase Interactions

Novel Hepoxilin Glutathione Conjugates with Biological Activity

Optically Pure Allylic Hydroperoxides: Mechanisms for Hydroperoxide Rearrangements

Arachidonate 12-Lipoxygenases

The Unique Characteristics of the Purified 5-Lipoxygenase from Potato Tubers and the Proposed Mechanism of Formation of Leukotrienes and Lipoxins

Arachidonic Acid Oxidation and Platelet Function

Role of Eicosanoids of the Lipoxygenäse Pathway in Vertebrate Reproduction

Endogenous Formation of Leukotriene C4 In Vivo and Characterization of Novel Metabolites Formed In Vitro and In Vivo

VIII. Lipid Peroxidation and Other Nonenzymatic Reactions of Oxygen

Vitamin E In Vivo

Interaction of Glutathione and α-Tocopherol in the Inhibition of Lipid Peroxidation in Rat Liver Microsomes

Glutathione and Vitamin E and the Control of Lipid Peroxidation of Rat Liver Nuclei

Mechanisms of Vitamin E Control of Lipid Peroxidation: Regeneration, Synergism, Asymmetry, Migration, and Metal Chelation

Vanadium as a Biological Hydrogen-Abstractive Agent

Constitutive and Inducible Repair Systems in Oxidative Stress

Oxidative Damage to Proteins Mediated by Singlet Oxygen

Molecular Mechanisms of Oxidative Cell Damage

Oxidative Myocardial Injury and Cardiac-Derived Experimental Systems

Mitochondrial Generation of Hydroxyl Radical During Reperfusion of Ischemic Myocardium

Role of Lipid Peroxides in Aging

Hepatocellular Regeneration as a Determinant of Halomethane Hepatotoxicity

Structure Activity Correlations of 1,4-Dihydropyridines as Reducing Agents

Modulation of Tubulin Tyrosinolation in Human Neutrophils by the NADPH Oxidase-Mediated Respiratory Burst

Isolation and Characterization of a Mammalian Hydroxyacid-Oxoacid Transhydrogenase

Author Index

Key Word Index

Symposium Delegates