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Biological NMR Part B - 1st Edition - ISBN: 9780128167625, 9780128167632

Biological NMR Part B, Volume 615

1st Edition

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Serial Volume Editor: A.Joshua Wand
Hardcover ISBN: 9780128167625
eBook ISBN: 9780128167632
Imprint: Academic Press
Published Date: 16th January 2019
Page Count: 544
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Table of Contents

1. Companion Simulations and Modeling to NMR-Based Dynamical Studies of Proteins
Kim A. Sharp
2. Reverse Micelle Encapsulation of Proteins for NMR Spectroscopy
Brian Fuglestad, Bryan S. Marques, Christine Jorge, Nicole E. Kerstetter, Kathleen G. Valentine and A. Joshua Wand
3. Characterizing Protein Hydration Dynamics Using Solution NMR Spectroscopy
Christine Jorge, Bryan S. Marques, Kathleen G. Valentine and A. Joshua Wand
4. Understanding Protein Function Through an Ensemble Description Characterization of Functional States by 19F NMR
Christopher Di Pietrantonio, Aditya Pandey, Jerome Gould, Advait Hasabnis and Robert Scott Prosser
5. Overhauser Dynamic Nuclear Polarization for the Study of Hydration Dynamics, Explained
John M. Franck and Songi Han
6. Chemical Exchange
Arthur G. Palmer III and Hans Koss
7. Characterization of Internal Protein Dynamics and Conformational Entropy by NMR Relaxation
Matthew A. Stetz, José A. Caro, Sravya Kotaru, Xuejun Yao, Bryan Marques, Kathleen G. Valentine and A. Joshua Wand
8. NMR Methods for Characterizing the Basic Side Chains of Proteins: Electrostatic Interactions, Hydrogen Bonds, and Conformational Dynamics
Dan Nguyen, Chuanying Chen, B. Montgomery Pettitt and Junji Iwahara
9. Solid-State NMR Spectroscopy of RNA
Alexander Marchanka and Teresa Carlomagno
10. DNP-Assisted NMR Investigation of Proteins at Endogenous Levels in Cellular Milieu
Whitney N. Costello, Yiling Xiao and Kendra K. Frederick
11. Identification of Unknown Metabolomics Mixture Compounds by Combining NMR, MS, and Cheminformatics
Abigail Leggett, Cheng Wang, Da-Wei Li, Arpad Somogyi, Lei Bruschweiler-Li and Rafael Brüschweiler
12. STD NMR as a Technique for Ligand Screening and Structural Studies
Samuel Walpole, Serena Monaco, Ridvan Nepravishta and Jesus Angulo
13. An ELISA-Based Screening Platform for Ligand-Receptor Discovery
Sinem Ozgul, Sventja von Daake, Sumie Kakehi, Davide Sereni, Natalia Denissova, Carlie Hanlon, Yuanpeng Janet Huang, John K. Everett, Cuifeng Yin, Gaetano T. Montelione and Davide Comoletti
14. Protein–Small Molecule Interactions by waterLOGSY
Renjie Huang and Ivanhoe K.H. Leung
15. Applications of Dissolution-DNP for NMR Screening
Yaewon Kim and Christian Hilty


Biological NMR, Part B, the latest release in the Methods of Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Protein methyl labeling, Membrane protein expression – yeast, Protein aromatic labeling, His-tag/Metal contamination, Bicelles, nanodiscs & micelles MP host, PTM – phosphorylation, PTM – lipidation, Screening platform for receptor-ligand discovery, Solution Spectroscopy, Large protein strategies, NUS data collection/analysis, F19 incl. hydration, ODNP - hydration, Reverse micelle - Hydration, Solid State Spectroscopy, SS NMR membrane proteins, SS NMR soluble/aggregate proteins, SS DNP - general, SS NMR nucleic acids, and much more.

Key Features

  • Authoritative contributors
  • Protocols for state-of-the-art advances
  • Timeliness


A broad survey of recent advances in biological NMR including applications in drug discovery


No. of pages:
© Academic Press 2019
16th January 2019
Academic Press
Hardcover ISBN:
eBook ISBN:

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About the Serial Volume Editor

A.Joshua Wand

Dr. A. Joshua Wand teaches at the Department of Biochemistry & Biophysics, Perelman School of Medicine, University of Pennsylvania, USA

Affiliations and Expertise

University of Pennsylvania, USA