Biological Identification

1st Edition

DNA Amplification and Sequencing, Optical Sensing, Lab-On-Chip and Portable Systems

Editors: R. Paul Schaudies
Hardcover ISBN: 9780857095015
eBook ISBN: 9780857099167
Imprint: Woodhead Publishing
Published Date: 7th May 2014
Page Count: 470
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Table of Contents

  • Contributor contact details
  • Woodhead Publishing Series in Electronic and Optical Materials
  • Preface
  • Part I: Technology for DNA and RNA analysis of pathogens
    • 1. Nucleic acid sequencing for characterizing infectious and/or novel agents in complex samples
      • Abstract:
      • 1.1 Pathogen sequencing and applications in public health and biosecurity
      • 1.2 Next-generation sequencing (NGS) technologies and the sequencing landscape
      • 1.3 Characterization of known pathogens
      • 1.4 Discovery of novel agents
      • 1.5 Future trends
      • 1.6 Acknowledgments
      • 1.7 References
    • 2. Multiplexed, lateral flow, polymerase chain reaction (PCR) techniques for biological identification
      • Abstract:
      • 2.1 Introduction
      • 2.2 Real-time PCR: development and description
      • 2.3 Considerations when developing a real-time PCR assay
      • 2.4 Real-time PCR instrument platforms
      • 2.5 References
    • 3. Isothermal amplification of specific sequences
      • Abstract:
      • 3.1 Introduction
      • 3.2 Melting temperature (Tm) estimation and categories of isothermal amplification technologies
      • 3.3 Isothermal amplification based on DNA polymerases
      • 3.4 Isothermal amplification based on RNA polymerases
      • 3.5 Future prospects
      • 3.6 References
    • 4. Bead array technologies for genetic disease screening and microbial detection
      • Abstract:
      • 4.1 Introduction
      • 4.2 Luminex® xMAP® Technology
      • 4.3 Illumina VeraCode
      • 4.4 NanoString nCounter
      • 4.5 Applications
      • 4.6 Conclusion
      • 4.7 References
  • Part II: Lab-on-chip and portable systems for biodetection and analysis
    • 5. Electrochemical detection for biological identification
      • Abstract:
      • 5.1 Introduction
      • 5.2 Electrochemical techn

Description

Biological Identification provides a detailed review of, and potential future developments in, the technologies available to counter the threats to life and health posed by natural pathogens, toxins, and bioterrorism agents. Biological identification systems must be fast, accurate, reliable, and easy to use. It is also important to employ the most suitable technology in dealing with any particular threat. This book covers the fundamentals of these vital systems and lays out possible advances in the technology.

Part one covers the essentials of DNA and RNA sequencing for the identification of pathogens, including next generation sequencing (NGS), polymerase chain reaction (PCR) methods, isothermal amplification, and bead array technologies. Part two addresses a variety of approaches to making identification systems portable, tackling the special requirements of smaller, mobile systems in fluid movement, power usage, and sample preparation. Part three focuses on a range of optical methods and their advantages. Finally, part four describes a unique approach to sample preparation and a promising approach to identification using mass spectroscopy.

Biological Identification is a useful resource for academics and engineers involved in the microelectronics and sensors industry, and for companies, medical organizations and military bodies looking for biodetection solutions.

Key Features

  • Covers DNA sequencing of pathogens, lab-on-chip, and portable systems for biodetection and analysis
  • Provides an in-depth description of optical systems and explores sample preparation and mass spectrometry-based biological analysis

Readership

Biological Identification is a useful resource for academics and engineers involved in the microelectronics and sensors industry, and for companies, medical organisations and military bodies looking for biodetection solutions.


Details

No. of pages:
470
Language:
English
Copyright:
© Woodhead Publishing 2014
Published:
Imprint:
Woodhead Publishing
eBook ISBN:
9780857099167
Hardcover ISBN:
9780857095015
Paperback ISBN:
9780081015148

Reviews

A veritable encyclopedia of some of the latest advances in technology and procedures for biological detection and analysis., Dr. John Vitko, former Director of the Chemical and Biological Defense Division of the Science and Technology Directorate of the Department of Homeland Security


About the Editors

R. Paul Schaudies Editor

R. Paul Schaudies is the president and chief executive officer of GenArraytion. He served as scientific advisor to the EPA during the Anthrax incident in Washington D.C. and served on a dozen National Research Council committees due to his expertise in bio- and nanotechnology. He has also held research posts in the US Army, and is an author of several papers and reports on biological identification.

Affiliations and Expertise

GenArraytion Inc., USA