Biological Function of Gangliosides, Volume 101

1st Edition

Editors: L. Svennerholm A.K. Asbury R.A. Reisfeld K. Sandhoff G. Tettamanti G. Toffano K. Suzuki
Hardcover ISBN: 9780444816580
eBook ISBN: 9780080862262
Imprint: Elsevier Science
Published Date: 1st February 1994
Page Count: 408
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Table of Contents

List of contributors. Preface. Designation of schematic structure of gangliosides and allied glycosphingolipids. 1. Molecular basis of cell adhesion (Plenary lecture) (Gerald Edelman). Section I - Structure and metabolism of gangliosides. 2. Ganglioside metabolism: enzymology, topology and regulation. 3. Developmental regulation of ganglioside metabolism. 4. New mass spectral approaches to ganglioside structure determinations. 5. Principles of glycosphingolipid-oligosaccharide constitution. Section II - Gangliosides in neuronal differentiation and development. 6. Ganglioside turnover and neural cells function: a new perspective. 7. Gangliosides as modulators of neuronal calcium. 8. Cell adhesion molecule (NCAM and N-cadherin) dependent neurite outgrowth is modulated by gangliosides. 9. Significance of ganglioside-mediated glycosignal transduction in neuronal differentiation and development. 10. Ca2+-ganglioside-interactions in neuronal differentiation and development. Section III - Receptor and cell surface activities of gangliosides. 11. A GM1-ganglioside-binding protein in rat brain. 12. Receptors for cholera toxin and Escherichia coli heat-labile enterotoxin revisited. 13. Carbohydrate ligands of leukocyte adhesion molecules and their therapeutic potential. 14. Receptors for gangliosides and related glycosphingolipids on central and peripheral nervous system cell membranes. Section IV - Gangliosides and cancer. 15. Potential of genetically engineered anti-ganglioside GD2 antibodies for cancer immunotherapy. 16. Ganglioside phenotype of human gliomas in vivo and in vitro. 17. Gangliosides associated with primary brain tumors and their expression in cell lines established from these tumors. 18. Role of gangliosides in tumor progression. 19. Tumor gangliosides as targets for active specific immunotherapy of melanoma in man. Section V - Gangliosides and peripheral neuropathies.

Description

This book focuses on the role of gangliosides in three areas of medicine in which rapid progress has been made in the last decade: cancer, peripheral neuropathies and Alzheimer's disease. The volume further reflects progress in the pathogenesis of peripheral neuropathies, and the controversial role of gangliosides, also in therapeutic administration. There is a section on the role of gangliosides in neuronal differentiation and development and their receptor functions and cell surface activities. This excellent addition to the renowned Progress in Brain Research series also contains an invaluable plenary lecture on molecular basis of cell adhesion by Nobel prizewinner Gerald Edelman.


Details

No. of pages:
408
Language:
English
Copyright:
© Elsevier Science 1994
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080862262
Hardcover ISBN:
9780444816580

Reviews

This book focuses on the role of gangliosides in three areas of medicine in which rapid progress has been made in the last decade: cancer, peripheral neuropathies and Alzheimer's disease. The volume further reflects progress in the pathogenesis of peripheral neuropathies, and the controversial role of gangliosides, also in therapeutic administration. There is a section on the role of gangliosides in neuronal differentiation and development and their receptor functions and cell surface activities. This excellent addition to the renowned Progress in Brain Research series also contains an invaluable plenary lecture on molecular basis of cell adhesion by Nobel prizewinner Gerald Edelman.


About the Editors

L. Svennerholm Editor

Affiliations and Expertise

Dept. Psychiatry and Neurochemistry, Mölndal Hospital, Sweden

A.K. Asbury Editor

R.A. Reisfeld Editor

K. Sandhoff Editor

G. Tettamanti Editor

G. Toffano Editor

K. Suzuki Editor

Affiliations and Expertise

University of North Carolina, Pathology & Lab Medicine, 410 Brinkhous Bullitt Bldg, Chapel Hill, NC 27599, USA