Biological DNA Sensor

1st Edition

The Impact of Nucleic Acids on Diseases and Vaccinology

Editors: Ken Ishii Choon Kit Tang
Hardcover ISBN: 9780124047327
eBook ISBN: 9780124051683
Imprint: Academic Press
Published Date: 7th November 2013
Page Count: 368
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Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines.

Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics.

Key Features

  • Multi-authored by a distinguished panel of world-class experts
  • Ideal source of information for those wanting to learn about DNA sensing
  • Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them


Students, scientists and practitioners in innate immunology, autoimmune diseases and vaccinology

Table of Contents

List of Contributors


Section A: The Discovery of dsDNA Immunogenicity and the Definition of DNA Sensing Pathways

Chapter 1. Route to Discovering the Immunogenic Properties of DNA from TLR9 to Cytosolic DNA Sensors


The Importance of the Innate Immune System

Endosomal-Membrane Bound DNA Sensor – TLR9

Cytosolic DNA Sensors




Chapter 2. The PYHIN Family of Molecules and their Functions Sensing dsDNA


Members of the Pyhin Family

Structural Basis of DNA Recognition by PYHIN Proteins

Microbial DNA Sensing and Signaling by PYHIN Proteins

Transcriptional Regulation by PYHIN Proteins

Role of PYHIN Proteins in the Development of Autoimmunity

Regulation of PYHIN Proteins



Chapter 3. Cytosolic DNA-Sensing and the STING Pathway


The Toll-Like Pathway: TLR9 and CpG DNA

The STING Pathway and Intracellular DNA Signaling

STING and Inflammatory Disease

Other Sensors of Intracellular DNA



Chapter 4. Regulation of Intracellular dsDNA-Induced Innate Immune Responses by Autophagy-Related Proteins

Part I. Autophagy-Related Proteins and STING-Dependent IFN Responses

Part II. Autophagy and STING-Dependent Bactericidal Responses

Part III. Autophagy and AIM2-Dependent Inflammatory Responses



Section B: dsDNA and Its Part in Modulating Human Diseases

Chapter 5. Host DNA Induced Inflammation and Autoimmune Diseases


The Type I IFN System as the Crux of Autoimmunity

Self and Non-Self-DNA Recognition

Heterogeneity in Innate Receptors for DNA

Mechanisms Underlying Host DNA Induced Inflammation and Autoimmunity


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© Academic Press 2014
Academic Press
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About the Editor

Ken Ishii

Affiliations and Expertise

Vaccine Science Laboratory, Immunology Frontier Research Centre (IFReC), Osaka University, Japan

Choon Kit Tang

Affiliations and Expertise

Vaccine Science Laboratory, Malaria Immunology Laboratory, Host Defense Laboratory, Immunology Frontier Research Centre (IFReC), Osaka University, Osaka, Japan


"The overall themes are the discovery of double-stranded DNA immunogenicity and the definition of DNA sensing pathways, double-stranded DNA and its part in modulating human diseases, and the DNA sensing pathway and its impact on vaccinology.", April 2014