Biological Activities of Steroids in Relation to Cancer

Biological Activities of Steroids in Relation to Cancer

Proceedings of a Conference Sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, U. S. Department of Health, Education and Welfare

1st Edition - January 1, 1960

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  • Editors: Gregory Pincus, Erwin P. Vollmer
  • eBook ISBN: 9781483270579

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Description

Biological Activities of Steroids in Relation to Cancer covers the proceedings of the conference sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, and the U. S. Department of Health, Education and Welfare. The text focuses on the influence of steroids on medical approaches to the cure of cancer, including steroid chemistry, estrogen metabolism, and mammary cancer. The selection first offers information on steroids growth and cancer, advances in steroid chemistry, and the physiology and pharmacology of steroids affecting tumor growth. Discussions focus on rapid development of mammary cancer, pituitary functions, androgens, estrogens, and progestins. The book also ponders on the binding of steroid hormones by plasma proteins; the effects of steroids on the levels of the plasma 17-hydroxycorticosteroids and the serum protein-bound iodine; and the metabolism of dehydroisoandrosterone. The text evaluates studies on estrogen metabolism, biochemical parameters of estrogen action, and enzymatic transport of hydrogen by estrogenic hormones. The manuscript also elaborates on the fate of steroid estrogens in target tissues, effect of steroids on calcium dynamics, and steroids and experimental mammary cancer. The selection is a valuable source of information for readers interested in the use of steroids in treating cancer.

Table of Contents


  • Contents

    Contributors

    Preface

    I. Introduction

    1. Steroids, Growth, and Cancer

    Discussion

    II. Steroid Structure and Function

    2. Some Recent Advances in Steroid Chemistry

    Discussion

    3. Physiology and Pharmacology of Steroids Affecting Tumor Growth

    Discussion

    III. Steroid Metabolism and Biochemistry

    4. The Binding of Steroid Hormones by Plasma Proteins

    Discussion

    5. The Effects of Steroids on the Levels of the Plasma 17-Hydroxycorticosteroids and the Serum Protein-Bound Iodine

    Discussion

    6. The Metabolism of Dehydroisoandrosterone

    Discussion

    7. Recent Studies on Estrogen Metabolism

    Discussion

    8. Biochemical Parameters of Estrogen Action

    Discussion

    9. Enzymatic Transport of Hydrogen by Estrogenic Hormones

    Discussion

    10. Fate of Steroid Estrogens in Target Tissues

    Discussion

    11. The Prostate As a Target Organ for Steroids

    Discussion

    12. Effect of Steroids on Calcium Dynamics

    Discussion

    13. The Effect of Estrogen Therapy on Incorporation of Formate-C14 into Human Breast Cancer in Vitro

    Discussion

    IV. Steroids and Experimental Tumors

    14. Studies of Hormone Dependency Employing Interstitial Cell Testicular Tumors of Mice

    Discussion

    15. Steroid-Responsive Neoplasms in Rats and Mice

    Discussion

    16. Steroids and Experimental Mammary Cancer

    Discussion

    17. Steroid Effects on Heterologously-Transplanted Human Tumors

    Discussion

    18. Steroid-Induced Tumors in Animals

    Discussion

    V. Hormones and Human Cancer

    19. Evaluation of Endocrine Ablative Surgery in the Treatment of Mammary Carcinoma: A Preliminary Study on Survival

    Discussion

    20. Testosterone Propionate Therapy of Breast Cancer—A Report for the Cooperative Breast Cancer Group

    21. Hormonal Therapy of Breast Cancer

    Discussion

    22. Evaluation of 4-Androstene-3ß,l7ß-diol Diacetate in the Treatment of Advanced Breast Cancer

    23. Δ1-Testololactone, Androsterone, and 5α-Androstane-3α,l7ß-diol Dipropionate in the Treatment of Advanced Breast Cancer

    24. An Evaluation of 9α-Bromo-ll-ketoprogesterone in the Treatment of Metastatic Breast Carcinoma

    25. Comparison of the Antitumor Effects of 17α-Methyl-19-Nortestosterone and Testosterone Propionate in Advanced Mammary Carcinoma

    26. The Cooperative Study Program in Therapy of Advanced Prostatic Cancer

    Discussion

    27. The Sex Hormones and Cortisone in the Treatment of Inoperable Bronchogenic Carcinoma

    Discussion

    28. Clinical Observations on the Effect of Progesterone in the Treatment of Metastatic Endometrial Carcinoma

    Discussion

    29. Steroid Metabolism in Endocrine Tumors

    Discussion

    30. Regression of Adrenal Cancer and Suppression of Adrenal Function in Man by o,p'-DDD

    Discussion

    31. Serum Proteins in Breast Carcinoma: Effects of Androgen Therapy

    32. Cellular Prognostic Factors in Breast Cancer Hormone Therapy

    Discussion

    Glossary

    Author Index

    Subject Index


Product details

  • No. of pages: 546
  • Language: English
  • Copyright: © Academic Press 1960
  • Published: January 1, 1960
  • Imprint: Academic Press
  • eBook ISBN: 9781483270579

About the Editors

Gregory Pincus

Erwin P. Vollmer

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