Methods and Applications

1st Edition - October 21, 2021

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  • Editors: Dev Bukhsh Singh, Rajesh Kumar Pathak
  • eBook ISBN: 9780323900058
  • Paperback ISBN: 9780323897754

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Bioinformatics: Methods and Applications provides a thorough and detailed description of principles, methods, and applications of bioinformatics in different areas of life sciences. It presents a compendium of many important topics of current advanced research and basic principles/approaches easily applicable to diverse research settings. The content encompasses topics such as biological databases, sequence analysis, genome assembly, RNA sequence data analysis, drug design, and structural and functional analysis of proteins. In addition, it discusses computational approaches for vaccine design, systems biology and big data analysis, and machine learning in bioinformatics.It is a valuable source for bioinformaticians, computer biologists, and members of biomedical field who needs to learn bioinformatics approaches to apply to their research and lab activities.

Key Features

  • Covers basic and more advanced developments of bioinformatics with a diverse and interdisciplinary approach to fulfill the needs of readers from different backgrounds
  • Explains in a practical way how to decode complex biological problems using computational approaches and resources
  • Brings case studies, real-world examples and several protocols to guide the readers with a problem-solving approach


Graduate students of bioinformatics; biomedical researchers in general

Table of Contents

  • 1. Introduction to Basics of Bioinformatics
    2. Biological Databases and their Applications
    3. Biological Sequence Analysis
    4. Genome Assembly and Annotation
    5. Computational Molecular Phylogeny: Concepts and Applications
    6. Applications and challenges of microarray and RNA-sequencing
    7. RNAseq Data Analysis
    8. Analysis of SSR and SNP Markers
    9. Gene Ontology (GO): Application and Importance in Functional Annotation of the Genomic Data
    10. Metagenomics: The Boon for Microbial World Knowledge and Current Challenges
    11. Protein structure Prediction
    12. Structural and Functional analysis of protein
    13. Computational Approaches in Drug designing
    14. Structure-Based Drug Designing
    15. Ligand-Based Drug Designing
    16. Discovery and Optimization of Lead Molecules in Drug Designing
    17. Pharmacophore modeling and its applications
    18. Molecular Docking and Molecular Dynamics Simulation
    19. Pharmacokinetics and Pharmacodynamics analysis of Drug Candidates
    20. Computational Approaches for Vaccine Designing
    21. Metabolomics and Flux Balance Analysis
    22. Topological Parameters, Patterns, and Motifs in Biological Networks
    23. Network Biology and its Application
    24. Pathway Modeling and Simulation Analysis
    25. Systems Biology and Big Data Analytics
    26. Machine Leaning in Bioinformatics
    27. Bioinformatics and Biological Data mining

Product details

  • No. of pages: 510
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: October 21, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780323900058
  • Paperback ISBN: 9780323897754

About the Editors

Dev Bukhsh Singh

He received BSc, and MSc from University of Allahabad and MTech (Bioinformatics) at Indian Institute of Information Technology. He is PhD in Biotechnology from Gautam Buddha University. He has been actively involved in teaching and research since 2009, is teaching Bioinformatics, Biostatistics, Proteomics and Genomics, and other courses to BSc and MSc Biotechnology students and his areas of research are molecular modeling, chemo-informatics, and drug designing. He authored numerous research articles and book chapters in the fields of computational biology, medicinal research, molecular modeling, drug design, and systems biology. He published two edited books: "Frontiers in Protein Structure, Function, and Dynamics" and "Computer-Aided Drug Design". He is a member of various national and international academic bodies and is a reviewer for several international journals.

Affiliations and Expertise

Assistant Professor at Department of Biotechnology, Institute of Biosciences and Biotechnology, Chhatrapati Shahu Ji Maharaj University, India

Rajesh Kumar Pathak

Rajesh Kumar Pathak completed his BSc from Barkatullah University, Bhopal, MSc from Chhatrapati Shahu Ji Maharaj University, Kanpur, and PhD from Uttarakhand Technical University, Dehradun, India. He has authored several articles in international journals including, Scientific Reports, Computational Biology and Chemistry, OMICS: A Journal of Integrative Biology, Frontiers in Plant Science, 3 Biotech, Journal of Biomolecular Structure and Dynamics, etc. His research interests lie in the areas of the genome and transcriptome assembly and annotation, microarray data analysis, pathway modeling, and network analysis, molecular docking, virtual screening, and molecular dynamics simulation. He has worked as a Teaching Personnel at G. B. Pant University of Agriculture & Technology, Pantnagar, India, and Teaching Assistant at the School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India.

Affiliations and Expertise

Post-Doctoral Researcher at Chung-Ang University, Anseong, Gyeonggi-do, Republic of Korea

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