Biofluid Mechanics

Biofluid Mechanics

An Introduction to Fluid Mechanics, Macrocirculation, and Microcirculation

1st Edition - September 28, 2011

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  • Authors: Wei Yin, Mary Frame
  • eBook ISBN: 9780123813848

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Both broad and deep in coverage, Rubenstein shows that fluid mechanics principles can be applied not only to blood circulation, but also to air flow through the lungs, joint lubrication, intraocular fluid movement and renal transport. Each section initiates discussion with governing equations, derives the state equations and then shows examples of their usage. Clinical applications, extensive worked examples, and numerous end of chapter problems clearly show the applications of fluid mechanics to biomedical engineering situations. A section on experimental techniques provides a springboard for future research efforts in the subject area.

Key Features

  • Uses language and math that is appropriate and conducive for undergraduate learning, containing many worked examples and end of chapter problems
  • All engineering concepts and equations are developed within a biological context
  • Covers topics in the traditional biofluids curriculum, as well as addressing other systems in the body that can be described by biofluid mechanics principles, such as air flow through the lungs, joint lubrication, intraocular fluid movement, and renal transport
  • Clinical applications are discussed throughout the book, providing practical applications for the concepts discussed.


Undergraduate and graduate students in biomedical engineering and mechanical engineering

Table of Contents

  • Preface

    Chapter 1. Introduction

    1.1. Note to Students About the Textbook

    1.2. Biomedical Engineering

    1.3. Scope of Fluid Mechanics

    1.4. Scope of Biofluid Mechanics

    1.5. Dimensions and Units

    Chapter 2. Fundamentals of Fluid Mechanics

    2.1. Fluid Mechanics Introduction

    2.2. Fundamental Fluid Mechanics Equations

    2.3. Analysis Methods

    2.4. Fluid as a Continuum

    2.5. Elemental Stress and Pressure

    2.6. Kinematics: Velocity, Acceleration, Rotation and Deformation

    2.7. Viscosity

    2.8. Fluid Motions

    2.9. Two-Phase Flows

    2.10. Changes in the Fundamental Relationships on the Microscale

    2.11. Fluid Structure Interaction

    Chapter 3. Conservation Laws

    3.1. Fluid Statics Equations

    3.2. Buoyancy

    3.3. Conservation of Mass

    3.4. Conservation of Momentum

    3.5. Momentum Equation with Acceleration

    3.6. The First and Second Laws of Thermodynamics

    3.7. The Navier-Stokes Equations

    3.8. Bernoulli Equation

    Chapter 4. The Heart

    4.1. Cardiac Physiology

    4.2. Cardiac Conduction System/Electrocardiogram

    4.3. The Cardiac Cycle

    4.4. Heart Motion

    4.5. Heart Valve Function

    4.6. Disease Conditions

    Chapter 5. Blood Flow in Arteries and Veins

    5.1. Arterial System Physiology

    5.2. Venous System Physiology

    5.3. Blood Cells and Plasma

    5.4. Blood Rheology

    5.5. Pressure, Flow, and Resistance: Arterial System

    5.6. Pressure, Flow, and Resistance: Venous System

    5.7. Wave Propagation in Arterial Circulation

    5.8. Flow Separation at Bifurcations and at Walls

    5.9. Flow Through Tapering and Curved Channels

    5.10. Pulsatile Flow and Turbulence

    5.11. Disease Conditions

    Chapter 6. Microvascular Beds

    6.1. Microcirculation Physiology

    6.2. Endothelial Cell and Smooth Muscle Cell Physiology

    6.3. Local Control of Blood Flow

    6.4. Pressure Distribution Throughout the Microvascular Beds

    6.5. Velocity Distribution Throughout the Microvascular Beds

    6.6. Interstitial Space Pressure and Velocity

    6.7. Hematocrit/Fahraeus-Lindquist Effect/Fahraeus Effect

    6.8. Plug Flow in Capillaries

    6.9. Characteristics of Two-phase Flow

    6.10. Interactions Between Cells and the Vessel Wall

    6.11. Disease Conditions

    Chapter 7. Mass Transport and Heat Transfer in the Microcirculation

    7.1. Gas Diffusion

    7.2. Glucose Transport

    7.3. Vascular Permeability

    7.4. Energy Considerations

    7.5. Transport through Porous Media

    7.6. Microcirculatory Heat Transfer

    7.7. Cell Transfer During Inflammation/White Blood Cell Rolling and Sticking

    Chapter 8. The Lymphatic System

    8.1. Lymphatic Physiology

    8.2. Lymph Formation

    8.3. Flow Through the Lymphatic System

    8.4. Disease Conditions

    Chapter 9. Flow in the Lungs

    9.1. Lung Physiology

    9.2. Elasticity of the Lung Blood Vessels and Alveoli

    9.3. Pressure-Volume Relationship for Air Flow in the Lungs

    9.4. Oxygen/Carbon Dioxide Diffusion

    9.5. Oxygen/Carbon Dioxide Transport in the Blood

    9.6. Compressible Fluid Flow

    9.7. Disease Conditions

    Chapter 10. Intraocular Fluid Flow

    10.1. Eye Physiology

    10.2. Aqueous Humor Formation

    10.3. Aquaporins

    10.4. Flow of Aqueous Humor

    10.5. Intraocular Pressure

    10.6. Disease Conditions

    Chapter 11. Lubrication of Joints

    11.1. Skeletal Physiology

    11.2. Formation of Synovial Fluid

    11.3. Synovial Fluid Flow

    11.4. Mechanical Forces Within Joints

    11.5. Disease Conditions

    Chapter 12. Flow Through the Kidney

    12.1. Kidney Physiology

    12.2. Glomerular Filtration

    12.3. Tubule Reabsorption/Secretion

    12.4. Sodium Balance/Water Balance

    12.5. Compartmental Analysis for Urine Formation

    12.6. Extracorporeal Flows: Dialysis

    12.7. Disease Conditions

    Chapter 13. In Silico Biofluid Mechanics

    13.1. Computational Fluid Dynamics

    13.2. Fluid Structure Interaction Modeling

    13.3. Buckingham Pi Theorem and Dynamic Similarity

    Chapter 14. In vitro Biofluid Mechanics

    14.1. Particle Imaging Velocimetry

    14.2. Laser Doppler Velocimetry

    14.3. Flow Chambers: Parallel Plate/Cone-and-Plate Viscometry

    Chapter 15. In vivo Biofluid Mechanics

    15.1. Live Animal Preparations

    15.2. Doppler Ultrasound

    15.3. Phase Contrast Magnetic Resonance Imaging

    15.4. Review of Other Techniques

    Further Readings Section


Product details

  • No. of pages: 410
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: September 28, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780123813848

About the Authors

Wei Yin

Dr. Yin conducts research into coronary artery disease, specifically how altered blood flow and stress distribution affect platelet and endothelial cell behavior and lead to cardiovascular disease initiation.

Affiliations and Expertise

Associate Professor and Undergraduate Program Director, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA

Mary Frame

The focus of Dr. Frame’s research is in integrating signal transduction events with physical properties of blood flow at the microvascular level, with the long term research goal of understanding the two phase question of how solute distribution and transport are coupled in the microcirculation.

Affiliations and Expertise

Professor, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA

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