Bioenergetics

Bioenergetics

3rd Edition - July 3, 2002

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  • Authors: David Nicholls, Stuart Ferguson
  • eBook ISBN: 9780080527932

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Description

This new edition of Bioenergetics presents a clear and up-to-date explanation of the chemiosmotic theory and covers mitochondria, bacteria, and chloroplasts. It takes account of the many newly determined structures, such as ATP synthase and the two photosystems of photosynthesis, that provide molecular insight into chemiosmotic energy transduction. This edition includes additional color figures of protein structures and many newly drawn illustrations designed to enable the reader to grasp the fundamental insights that are derived from knowing the structure. Every chapter has been extensively revised and updated and a new chapter on the study of the bioenergetics of mitochondria in the intact cell is included to satisfy the enormous interest in this topic. Written for students and researchers alike, this book is the most current text on the chemiosmotic theory and membrane bioenergetics available.

Key Features

Key Features
* Chapter on the study of bioenergetics of mitochondria in the intact cell
* Appendix listing protein structure resources
* Additional colour plates of protein structures
* Many newly drawn illustrations
* Website

Readership

Undergraduates, graduates, postgraduates, and researchers working in biochemistry and the biological sciences.

Table of Contents

  • Preface
    Note to the Reader
    Glossary

    CHEMIOSMOTIC ENERGY TRANSDUCTION
    Introduction
    The Chemiosmotic Theory: Fundamentals
    The Basic Morphology of Energy-Transducing Membranes
    Overview

    ION TRANSPORT ACROSS ENERGY-CONSERVING MEMBRANES
    Introduction
    The Classification of Ion Transport
    Bilayer-Mediated Transport
    Protein-Catalyzed Transport
    Swelling and the Co-ordinate Movement of Ions Across Membranes

    QUANTITATIVE BIOENERGETICS: THE MEASUREMENT OF DRIVING FORCES
    Introduction
    Gibbs Energy and Displacement from Equilibrium
    Oxidation-Reduction (Redox) Potentials
    Ion Electrochemical Potential Differences
    Photons
    Bioenergetic Interconversions and Thermodynamic Constraints on their Stoichiometries
    The Equilibrium Distributions of Ions, Weak Acids and Weak Bases
    Membrane Potentials, Diffusion Potentials, Donnan Potentials and Surface Potentials

    THE CHEMIOSMOTIC PROTON CIRCUIT
    Introduction
    The Measurement of Protonmotive Force
    The Stoicheiometry of Proton Extrusion by the Respiratory Chain
    The Stoicheiometry of Proton Uptake by the ATP Synthase
    Proton Current and Respiratory Control
    Proton Conductance
    Mitochondrial Respiration Rate and Metabolic Control Analysis
    Overall Parameters of Energy-Transduction
    Reversed Electron Transfer and the Proton Circuit Driven by ATP Hydrolysis
    ATP Synthesis Driven by an Artificial Protonmotive Force
    Kinetic Competence of Äp in the Proton Circuit
    Light-dependent ATP Synthesis by Bovine Heart ATP Synthase

    RESPIRATORY CHAINS
    Introduction
    Components of the Mitochondrial Respiratory Chain
    The Sequence of Redox Carriers in the Respiratory Chain
    The Mechanism of Electron Transfer
    Proton Translocation by the Respiratory Chain; "loops" or "conformational pumps" or both?
    Complex I (NADH-UQ Oxidoreductase)
    Delivering Electrons to Ubiquinone without Proton Translocation
    Ubiquinone and Complex III (bc1 or UQ-Cyt c Oxidoreductase)
    Cytochrome c and Complex IV (Cytochrome c Oxidase; Ferrocytochrome c; O2 Oxidoreductase)
    Overall Proton and Charge Movements Catalysed by the Respiratory Chain: Correlation with the P/O Ratio
    Superoxide Production by Complex I and III
    Oxidative Stress
    The Nicotinamide Nucleotide Transhydrogenase
    Electron Transport in Mitochondria of Non-Mammalian Cells
    Bacterial Resporatory Chains

    PHOTOSYNTHETIC GENERATORS OF PROTONMOTIVE FORCE
    Introduction
    The Light Reaction of Photosynthesis in Rhodobacter sphaeroides and Related Organisms
    The Generation by Illumination or Respiration of Äp in Photosynthetic Bacteria
    The Electron-Transfer and Light-Capture Pathway in Green Plants and Algae
    Bacteriorhodpsin and Halorhodopsin

    THE ATP SYNTHASE
    Introduction
    F1 and F0
    The Subunits of the F1F0-ATPase
    The Structure of F0 F1
    Enzymology of ATP Synthase
    Relating the Structure to Function for ATP Synthase
    Non-Thermodynamic Regulation of the ATP Synthase
    Proton Translocation by Other ATPases and Pyrophosphatases

    METABOLITE AND ION TRANSPORT
    Introduction
    Mitochondrial Cation Transporters
    Mitochondrial Metabolite Transporters
    The Transfer of Electrons from Cytoplasmic NADH to the Respiratory Chai
    The Phosphate and Adenine Nucleotide Transporters
    The Uncoupling Protein Family
    Bacterial Transport
    Transport (Movement) of Bacterial Cells
    Transport of Macromolecules Across Membranes

    MITOCHONDRIA IN THE CELL
    Introduction
    Monitoring ÄØm and ATP Synthesis in Intact Cells
    Mitochondria and Cellular Ca2+ Homeostasis
    Mitochondria and Programmed Cell Death
    Mitochondria and Necrotic Cell Death
    The Mitochondrial Genome
    Import and Assembly of Mitochondrial Proteins
    Mitochondrial Genetic Diseases
    Mitochondrial Involvement in Neurodegenerative Diseases

    References
    Appendix
    Index

Product details

  • No. of pages: 288
  • Language: English
  • Copyright: © Academic Press 2002
  • Published: July 3, 2002
  • Imprint: Academic Press
  • eBook ISBN: 9780080527932

About the Authors

David Nicholls

Affiliations and Expertise

Buck Institute, Novato, California, U.S.A.

Stuart Ferguson

Affiliations and Expertise

University of Oxford, U.K.

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