3rd Edition

Authors: David Nicholls Stuart Ferguson
Paperback ISBN: 9780125181211
eBook ISBN: 9780080527932
Imprint: Academic Press
Published Date: 3rd July 2002
Page Count: 288
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This new edition of Bioenergetics presents a clear and up-to-date explanation of the chemiosmotic theory and covers mitochondria, bacteria, and chloroplasts. It takes account of the many newly determined structures, such as ATP synthase and the two photosystems of photosynthesis, that provide molecular insight into chemiosmotic energy transduction. This edition includes additional color figures of protein structures and many newly drawn illustrations designed to enable the reader to grasp the fundamental insights that are derived from knowing the structure. Every chapter has been extensively revised and updated and a new chapter on the study of the bioenergetics of mitochondria in the intact cell is included to satisfy the enormous interest in this topic. Written for students and researchers alike, this book is the most current text on the chemiosmotic theory and membrane bioenergetics available.

Key Features

Key Features

  • Chapter on the study of bioenergetics of mitochondria in the intact cell
  • Appendix listing protein structure resources
  • Additional colour plates of protein structures
  • Many newly drawn illustrations
  • Website


Undergraduates, graduates, postgraduates, and researchers working in biochemistry and the biological sciences.

Table of Contents

Preface Note to the Reader Glossary

CHEMIOSMOTIC ENERGY TRANSDUCTION Introduction The Chemiosmotic Theory: Fundamentals The Basic Morphology of Energy-Transducing Membranes Overview

ION TRANSPORT ACROSS ENERGY-CONSERVING MEMBRANES Introduction The Classification of Ion Transport Bilayer-Mediated Transport Protein-Catalyzed Transport Swelling and the Co-ordinate Movement of Ions Across Membranes

QUANTITATIVE BIOENERGETICS: THE MEASUREMENT OF DRIVING FORCES Introduction Gibbs Energy and Displacement from Equilibrium Oxidation-Reduction (Redox) Potentials Ion Electrochemical Potential Differences Photons Bioenergetic Interconversions and Thermodynamic Constraints on their Stoichiometries The Equilibrium Distributions of Ions, Weak Acids and Weak Bases Membrane Potentials, Diffusion Potentials, Donnan Potentials and Surface Potentials

THE CHEMIOSMOTIC PROTON CIRCUIT Introduction The Measurement of Protonmotive Force The Stoicheiometry of Proton Extrusion by the Respiratory Chain The Stoicheiometry of Proton Uptake by the ATP Synthase Proton Current and Respiratory Control Proton Conductance Mitochondrial Respiration Rate and Metabolic Control Analysis Overall Parameters of Energy-Transduction Reversed Electron Transfer and the Proton Circuit Driven by ATP Hydrolysis ATP Synthesis Driven by an Artificial Protonmotive Force Kinetic Competence of Äp in the Proton Circuit Light-dependent ATP Synth


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© Academic Press 2003
Academic Press
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About the Author

David Nicholls

Affiliations and Expertise

Buck Institute, Novato, California, U.S.A.

Stuart Ferguson

Affiliations and Expertise

University of Oxford, U.K.


"Not only is Bioenergetics 3 comprehensive, but the material is presented in a reassuringly accessible form. ...this text is supremely successful." -THE BIOCHEMIST (December 2003) "Bioenergetics 3 is a worthy successor to the second edition, and one that I can enthusiastically recommend." —Aubrey D.N.J. de Grey University of Cambridge for MITOCHONDRION (2002)