Biochemistry, Pathology and Genetics of Pulmonary Emphysema

Biochemistry, Pathology and Genetics of Pulmonary Emphysema

Proceedings of an International Symposium Held in Sassari, Italy, 27-30 April 1980

1st Edition - January 1, 1981

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  • Editors: J. Bignon, G. L. Scarpa
  • eBook ISBN: 9781483157955

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Description

Biochemistry, Pathology and Genetics of Pulmonary Emphysema documents the proceedings of an international symposium held in Sassari, Italy, 27-30 April 1980. Research on the origins of emphysema has acquired more importance than functional diagnostic studies. There are various hypotheses concerning the development of emphysema. Some cases of emphysema are linked to defects in metabolic functions of the vessels while others are linked to a disturbance in repair processes. The papers in this volume are organized into four sections. Section 1 contains studies on the pathology and biochemistry of lung connective tissue. Section 2 deals with animal models. Section 3 on proteases and antiproteases includes studies on the characteristics and identification of biological specimens, and alpha1-proteinase inhibitor. Section 4 takes up the risk factors and therapeutic approaches for lung disease. Other papers in the volume were presented during two roundtable discussions on the biochemistry of connective tissue components in emphysema and therapeutic approaches.

Table of Contents


  • Foreword

    Section 1: Pathology and Biochemistry of Lung Connective Tissue

    Introductory Review: Pathological and Pathogenetic Aspects of Chronic Obstructive Lung Disease

    Evaluation of the Protease-Antiprotease Theory of Human Destructive Lung Disease

    Lung Elastin Content in Normal and Emphysematous Lungs

    Round Table Biochemistry of Connective Tissue Components in Emphysema

    The Measurement of Elastin Turnover by the Radioimmunoassay of Urinary Desmosine Excretion

    Antigenicity of Human Lung Elastin Peptides

    Measurement of Elastin Degradation In Vivo by Desmosine Radioimmunoassay

    Biochemical Measurement of Lung Connective Tissue

    Modifications of 14C-Glucosamine Incorporation into Hamster Lung Glycoconjugates in Elastase Induced Emphysema

    Glycosaminoglycans in Elastase Induced Emphysema

    Glycosaminoglycans (GAG) in the pathogenesis of the Flaccid Lung Syndrome

    Lung Scleroproteins in Young and Adult Rat and in Rat with Spontaneous Emphysema: Comparative Study by Biochemical and Histochemical Approach

    Section 2: Animal Models

    The Tissue Response to Exogenous Elastase

    Electron and Light Microscopic Studies of the Lungs of Chloramine-T Treated Dogs

    The Tight-Skin Mouse: an Animal Model of Inherited Emphysema

    Ultrastructural Evidence of Mucociliary Function Impairment Induced by Elastase

    General Discussion

    Chairmen Summaries

    Section 3: Proteases and Antiproteases

    A. Basic Aspects and Identification in Biological Specimens

    Pathophysiological Interpretation of Kinetic Constants of Protease Inhibitors

    Characterization of Different Elastases. Their Possible Role in the Genesis of Emphysema

    Interactions between Granulocyte Proteases and Protease Inhibitors in the Lung

    The Acid Stable Proteinase Inhibitors of the Respiratory Tract. Chemistry and Function

    Localization of a Low Molecular Weight Protease Inhibitor in the Respiratory Tract

    Characterization of a Bronchial Inhibitor in the Sputum of Chronic Bronchitics

    Proteases and Antiproteases in Bronchoalveolar Lavage

    Serum Derived Protease Inhibitors and Leucocyte Elastase in Sputum and the Effect of Infection

    A radioimmunoassay for a Granulocyte Protein as a Marker in Studies on the Turnover of Such Cells

    B. Alpha1-Proteinase Inhibitor

    Genetic Variants of the Pi System in Normans: Comparison with Some European Populations

    Respiratory Function Disturbances in Alpha1-Antitrypsin Deficiency

    Alpha1-Antitrypsin Phenotypes and Pi M Subtypes in Italy

    Alpha1-Antitrypsin Serum Concentration and Respiratory Symptoms in 1294 Healthy Men

    A Survey of Alpha1-Antitrypsin Deficiency by the British Thoracic Association

    Inactivation of Alpha1-Proteinase Inhibitor and Bronchial Mucous Proteinase Inhibitor by Cigarette Smoke In Vitro and In Vivo

    Oxidation of Alpha1-Proteinase Inhibitor as a Major, Contributing Factor in the Development of Pulmonary Emphysema

    Chairman Summary

    Section 4: Risk Factors and Therapeutic Approaches

    Genetic Factors in Chronic Obstructive Lung Disease

    Lung Toxicity of Some Atmospheric Pollutants

    Sex Hormones and the Flaccid Lung Syndrome

    Intrathoracic Airway Mechanics in Patients with Emphysema

    Round Table: Therapeutic Approaches

    Opportunities for the Specific Therapy of Obstructive Lung Disease

    Prevention of Elastase-Induced Experimental Emphysema by a Synthetic Elastase Inhibitor Administered Orally

    Comparative Effects of Reversible and Irreversible Specific Elastase Inhibitors on Elastase-Induced Emphysema

    Elastase and Lysozyme Secretion by Peritoneal Macrophages; Effects of Dexamethasone and Rifampin

    Conclusions

    Emphysema: Past, Present and Future

Product details

  • No. of pages: 428
  • Language: English
  • Copyright: © Pergamon 1981
  • Published: January 1, 1981
  • Imprint: Pergamon
  • eBook ISBN: 9781483157955

About the Editors

J. Bignon

G. L. Scarpa

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