Biochemistry of Vision

Biochemistry of Vision

1st Edition - January 28, 1983

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  • Author: Hitoshi Shichi
  • eBook ISBN: 9780323157414

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Biochemistry of Vision provides information pertinent to vision biochemistry. This book discusses the biochemical information derived primarily from studies on nonocular tissues and describes the biochemical reactions related to the function of the retina and pigmented epithelium. Organized into 16 chapters, this book begins with an overview of the visual system and the structure of the vertebrate eye. The text then proceeds with a discussion of photoreceptor, which has a highly membranous structure. Other chapters cover a brief discussion of several topics, including biomembranes, photochemistry, spectral properties of retinal isomers, and the photochemical properties of the chromophore of rhodopsin. This book discusses as well the properties and intramembrane disposition of rhodopsin. The final chapter deals with the biochemistry of photoreceptor disorders and summarizes the basic knowledge on neurotransmitters and electrophysiology in the retina. This book is intended for ophthalmologists and medical students who are interested in the molecular aspects of photoreceptor diseases.

Table of Contents

  • Preface

    1 Structure of the Eye

    I. Transparent Tissues

    II. Uvea

    III. Retina

    IV. Differentiation of Ocular Tissues


    2 Properties of Biomembranes

    I. Lipids

    II. Proteins

    III. Fluidity

    IV. Protein-Protein Interaction

    V. Liposomes


    3 Rod Outer Segment Membranes

    I. The Fluid Nature of Rod Membranes

    II. Disposition of Rhodopsin in the Membrane

    III. Phospholipids of Rod Membranes


    4 Photochemistry

    I. Energy of Photons

    II. Spin States of Electrons

    III. Electronic Orbitals and Energy States

    IV. Photochemical Energy Transfer

    V. Absorption Spectrum and Absorption



    5 Structure and Spectral Properties of Retinal Isomers

    I. Isomerism

    II. Spectroscopy


    6 Chromophore of Rhodopsin

    I. Retinal

    II. Spectral Properties of Rhodopsin


    7 Intermediates Formed by Photobleaching of Visual Pigments

    I. Hypsorhodopsin

    II. Bathorhodopsin

    III. Lumirhodopsin

    IV. Metarhodopsins

    V. Energetics

    VI. lodopsin


    8 Purification and Properties of Rhodopsin

    I. Extraction and Purification of Rhodopsin

    II. Preparation of Rod Outer Segments and Rod Disks

    III. Chemical Properties of Rhodopsin

    IV. Physical Properties


    9 Metabolism and Functions of Retinol and Its Derivatives

    I. Biosynthesis of Retinol

    II. Transport of Retinol (Retinol Binding Protein)

    III. Retinol Binding Protein within the Cell

    IV. Functions of Retinol and Its Derivatives


    10 Metabolism of the Retina and Pigmented Epithelium

    I. Vascular Systems in the Eye

    II. Metabolism of the Pigmented Epithelium

    III. Metabolism of the Retina


    11 Bacteriorhodopsin and Halorhodopsin

    I. Bacteriorhodopsin

    II. Halorhodopsin

    III. Evolutionary Significance


    12 Cell Biology of Photoreceptor Membranes

    I. Synthesis and Breakdown of Photoreceptor Membranes

    II. Assembly of Cell Membranes

    III. Assembly of Disk Membrane


    13 Cellular Receptors and Signal Transmission

    I. General Mechanisms of Signal Transmission

    II. Other Mechanisms


    14 Electrophysiology and Neurotransmitters

    I. Basic Aspects

    II. Retinal Neurons

    III. Neurotransmitters in the Nervous System

    IV. Neurotransmitters in the Retina


    15 Visual Excitation

    I. Ca2+ Model

    II. Biochemical Model


    16 Biochemistry of Photoreceptor Disorders

    I. Retinitis Pigmentosa

    II. Gyrate Atrophy of the Choroid and Retina

    III. Uveoretinal Autoimmune Diseases



Product details

  • No. of pages: 290
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 28, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323157414

About the Author

Hitoshi Shichi

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