Biochemistry of the Glycosidic Linkage an Integrated View

Biochemistry of the Glycosidic Linkage an Integrated View

1st Edition - January 1, 1972

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  • Editor: Romano Piras
  • eBook ISBN: 9780323142410

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Biochemistry of the Glycosidic Linkage: An Integrated View is a collection of papers presented at The Pan-American Association of Biochemical Societies Symposium, held in San Carlos de Bariloche, Argentina on November 8-11, 1971. This symposium is organized as a tribute to Luis F. Leloir and his contributions in the field glycosidic linkage. This book is divided into six sessions encompassing 57 chapters. The opening session discusses the role of biochemical mechanisms in the glycosidic linkage formation. The following sessions examine the metabolic functions of some disaccharides, such as trehalose, sucrose, glucose, and starch. These sessions also look into the biosynthesis, function, and properties of carbohydrates containing polymers. The discussion then shifts to the control of enzyme biosynthesis involved in the glycosidic linkage metabolism, with particular emphasis on alpha-amylase, lactose synthetase, phosphorylase, and neuraminidase enzymes. Another session is devoted to the regulatory mechanisms and control of glycogen metabolism. The concluding session covers the genetic analysis and biochemical characterization of the enzymes involved in the glycosidic linkage metabolism. Biochemists and carbohydrate researchers will find this text invaluable.

Table of Contents

  • Participants



    Opening Address: Biosynthesis of Polysaccharides Seen from Buenos Aires

    Session I. Biochemical Mechanisms of the Glycosidic Linkage Formation

    Role and Mechanisms of Transglycosylation Reactions

    The Role of Pyridine Nucleotides in Interconversions of Nucleoside Diphosphate Sugars

    Virus Control of the Synthesis of Glycosidic Linkages: Glycoprotein and Glycolipid Sialic Acid Transferases from Normal and SV40 Transformed Balb/c Cells

    The Role of Polyisoprenyl Alcohols in the Biosynthesis of the Peptidoglycan of Bacterial Cell Walls and Other Complex Polysaccharides


    A Cytidylic-Guanylic Acid-Glucose-Peptide Nucleotide from Eggs of Bufo arenarum

    Sugar Moiety of Bleomycins

    UDP-Galactose-4'-epimerase A 4-Ulose NAD+ Oxido-Reductase

    The Chemical Synthesis of Pyrophosphodiesters of Carbohydrates and Isoprenoid Alcohols: The "Lipid Intermediates" of Bacterial Polysaccharide Biosynthesis

    Possible Metal Ion Participation in the UDP-Glucose-4'-epimerase Reaction

    The Structure of the Compound Formed by Glucose Transfer from Dolichol-Monophosphate-Glucose to a Microsomal Acceptor

    Further Studies on the Structure of the Compound that Receives Glucose from Dolichol-Monophosphate-Glucose

    Lipid-Linked Intermediates in the Biosynthesis of Polysaccharides in Acetobacter xylinum

    Dolichol Phosphate and Mannose Transferase Reactions in Animal Systems

    A Plant Mannosyl-Lipid Intermediate

    The Role of a Lipid-Intermediate in Mannose-Polymer Biosynthesis in Yeast

    Session II. The Metabolic Function of Some Disaccharides

    The Role of Sucrose and Sucrose Synthetase in Helianthus tuberosus

    Role of α-Lactalbumin in the Lactose Synthetase Reaction

    The Function of Trehalase in the Active Transport of Glucose in the Mammalian Kidney


    Sucrose and Its Connection with the Metabolism of Starch

    Metabolism of Trehalose in Euglena gracilis

    Enzymic Mechanism of Starch Biosynthesis in Developing Rice Seeds

    Session III. Function and Organization of Carbohydrate Containing Polymers

    Biosynthesis of Polysaccharides from Sugar Nucleotides in Plants

    Isoprenoid Intermediates in the Biosynthesis of Bacterial Walls

    Some Aspects of the Structure and Biosynthesis of Connective Tissue Proteoglycans

    Biochemical Basis for Blood Groups in Man


    ß-Glucan Synthesis by Lolium multiflorum Endosperm Preparations

    Paracrystalline Glycogen

    Detection of Multienzyme (Phosphorylase b, Phosphorylase Kinase)- Primer Complexes at the Level of Purified Zonal Centrifuged Sarcoplasmic Vesicles Extracted from Rabbit Skeletal Muscle

    The Mechanism of Glucose Transfer by Phosphorylase and Glycogen Synthetase

    The Biosynthesis of Brain Gangliosides

    Chemical Structure and Biosynthesis of the Glycoprotein Coat of the TA3 Cancer Cell

    Aspects on the Structure and Function of Phytotoxic Glycopeptides and Other Glycosides from Plant Pathogens

    Session IV. Control of the Biosynthesis of Enzymes Involved in the Metabolism of the Glycosidic Linkage

    The Program of Polysaccharide and Disaccharide Synthesis during the Development of Dictyostelium discoideum

    Gibberellic Acid and α-Amylase Induction in Germinating Cereal Seeds

    The Developmental Pattern of Enzymes Related to Glycogen Metabolism in Chick Embryo Muscle

    Development of the Lactose Synthetase System


    A Primer-less Form of Potato Phosphorylase: Possible Involvement in Starch Biosynthesis

    Studies on Particulate Transglucosylases from Potato Tubers

    The Soluble and Particulate Neuraminidases of Rat Brain and Rat Liver: Developmental Changes

    Session V: Control of Glycogen Metabolism

    Regulatory Mechanisms in the Biosynthesis of Plant Starch and Bacterial Glycogen

    Synthesis of an αl, 4-Glucan by ADP-Glucose: αl, 4-Glucan 4-Glucosyl Transferases in Absence of Primer

    Adenyl Cyclase and the Regulation of Glycogen Metabolism in Neurospora crassa

    The Actions of Epinephrine and Other Stimuli That Promote Glycogenolysis in Cardiac and Skeletal Muscle

    Insulin and Glycogen Synthase


    Glycogen from Thermophilic Bacteria

    Synthesis of a Glucan Protein from UDP-Glucose

    The Relationship between Hormonal and Metabolite Regulation of Tadpole Liver Glycogen Synthetase

    Regulatory Mechanisms in the Metabolism of Liver Glycogen

    Session VI: Genetic Aspects of the Enzymes Involved in the Metabolism of the Glycosidic Linkage

    Genetic Analysis and Biochemical Characterization of Mutants Impairing Glycogen Metabolism in Escherichia coli Kl2

    The Turnover of (2-3H) Glucose: An Assay for Diagnosis of Type I Glycogenosis

    Dynamic Studies of Glycogen Metabolism in Glycogen Storage Disease Using Fibroblast Cultures Derived from Patients and Their Families

    The Biochemical Basis of the Inborn Errors of Mucopolysaccharide Metabolism


    The Control of the Biosynthesis of Sucrases in Bacillus subtilis: Genetic and Biochemical Aspects

    The Effect of Trehalose on the Glycogen Turnover Rate in Human Fibroblasts

    A Low-Molecular Weight Form of Glycogen Occurring in a Case of Glycogen Storage Disease

    Hyaluronidase Activity in Lysosomes of Rat Liver and Hepatoma

    The Effect of Hyaluronidase in the Degradation and Excretion of Mucopolysaccharides in the Hunter's and Hurler's Syndromes (Gargoylism)

    A New Mucopolysaccharidosis Characterized by Excretion of Chondroitin Sulfate C of Low Sulfate Content

    Hereditary Galactosemia and Lactose Biosynthesis

    Closing Address: Some Salient Features of the Enzymatic Synthesis of the Glycosidic Bond

    Subject Index

Product details

  • No. of pages: 814
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 1, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9780323142410

About the Editor

Romano Piras

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