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Biochemistry of Lipids, Lipoproteins and Membranes
6th Edition - July 24, 2015
Editors: Neale Ridgway, Roger McLeod
Language: English
Hardback ISBN:9780444634382
9 7 8 - 0 - 4 4 4 - 6 3 4 3 8 - 2
eBook ISBN:9780444634498
9 7 8 - 0 - 4 4 4 - 6 3 4 4 9 - 8
Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biol…Read more
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Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six,
contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information.
It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences.
Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry
References from current literature will be included in each chapter to facilitate more in-depth study
Key concepts are supported by figures and models to improve reader understanding
Chapters provide historical perspective and current analysis of each topic
researchers and graduate students of biochemistry, cell biology, lipid biochemistry, and molecular biology
Preface
Chapter 1. Functional Roles of Lipids in Membranes
1. Introduction and Overview
2. Diversity in Lipid Structure
3. Properties of Lipids in Solution
4. Engineering of Membrane Lipid Composition
5. Role of Lipids in Cell Function
6. Summary and Future Directions
Chapter 2. Approaches to Lipid Analysis
1. Introduction and Overview
2. Lipid Diversity
3. Chromatographic-Based Analysis of Lipids
4. Basic Concepts of Analytical Biochemistry
5. Lipid Mass Spectrometry
6. Future Directions
Chapter 3. Fatty Acid and Phospholipid Biosynthesis in Prokaryotes
1. Overview of Bacterial Lipid Metabolism
2. Membrane Systems of Bacteria
3. The Initiation Module
4. The Elongation Module
5. The Acyltransfer Module
6. The Phospholipid Module
7. Genetic Regulation of Lipid Metabolism
8. Future Directions
Chapter 4. Lipid Metabolism in Plants
1. Introduction
2. Plant Lipid Geography
3. Acyl-Acyl Carrier Protein Synthesis in Plants
4. Acetyl-Coenzyme A Carboxylase and Control of Fatty Acid Synthesis
5. Phosphatidic Acid Synthesis Occurs via Prokaryotic and Eukaryotic Acyltransferases
6. Membrane Glycerolipid Synthesis
7. Lipid Storage in Plants
8. Protective Lipids: Cutin, Waxes, Suberin and Sporopollenin
9. Sphingolipid Biosynthesis
10. Oxylipins as Plant Hormones
11. Sterol and Isoprenoid Biosynthesis
12. Future Prospects
Chapter 5. Fatty Acid Handling in Mammalian Cells
1. Introduction
2. Fatty Acid Biosynthesis
3. Fatty Acid Uptake, Activation and Trafficking
4. Fatty Acid Storage as Triacylglycerol in Lipid Droplets
5. Fatty Acid Use for Energy
6. Fatty Acids and Signalling
7. Fatty Acids and Disease Pathogenesis
8. Future Directions
Chapter 6. Fatty Acid Desaturation and Elongation in Mammals
1. Introduction
2. Elongation Reactions of Long-Chain Fatty Acids
3. Desaturation of Long-Chain Fatty Acid in Mammals
4. Transcriptional Regulation of Desaturases and Elongases
5. Summary and Future Directions
Chapter 7. Phospholipid Synthesis in Mammalian Cells
1. Introduction
2. Biosynthesis of Phosphatidic Acid and Diacylglycerol
3. Phosphatidylcholine Biosynthesis and Regulation
4. Phosphatidylethanolamine Biosynthesis and Regulation
5. Phosphatidylserine Biosynthesis and Regulation
6. Phosphatidylinositol and Polyphosphorylated Phosphatidylinositol
7. Biosynthesis of Phosphatidylglycerol and Cardiolipin
8. Fatty Acid Remodelling of Phospholipids
9. Future Directions
Chapter 8. Phospholipid Catabolism
1. Introduction
2. The Phospholipase A Family
3. Phospholipase C
4. Phospholipase D
5. Future Directions
Chapter 9. The Eicosanoids: Cyclooxygenase, Lipoxygenase and Epoxygenase Pathways
1. Introduction
2. Prostanoids
3. Prostanoid Biosynthesis
4. Prostanoid Catabolism and Mechanisms of Action
5. Leukotrienes and Lipoxygenase Products
6. Cytochrome P450S and Epoxygenase Pathways
7. Future Directions
Chapter 10. Sphingolipids
1. Introduction
2. Nomenclature and Structure
3. Sphingolipids Biosynthesis
4. Sphingolipid Degradation
5. Sphingolipid Signalling and Roles in Cell Regulation
2. Removal of Low-Density Lipoprotein from the Circulation
3. Post-translational Modulators of Low-Density Lipoprotein Receptor Activity
4. Receptor-Mediated Removal of Triacylglycerol-Rich Lipoproteins from the Plasma
5. Other Relatives of the Low-Density Lipoprotein Receptor Family
6. Roles of Lipoprotein Receptors in Signal Transduction
7. Scavenger Receptors: Lipid Uptake and Beyond
8. Outlook
Chapter 18. Atherosclerosis
1. Atherosclerosis
2. Lipoprotein Transport in Atherosclerosis
3. Lipoprotein Receptors and Lipid Transporters
4. Contributions of Lipoprotein-Mediated Inflammation to Atherosclerosis
5. New Emerging Mechanisms of Lipid Metabolism Influencing Atherosclerosis
6. Traditional and Evolving Lipid-Lowering Therapies for the Treatment of Atherosclerosis
7. Future Directions
Chapter 19. Diabetic Dyslipidaemia
1. Introduction to the Typical Dyslipidaemia of Insulin-Resistant States
2. Dyslipidaemia of Insulin-Resistant States: Key Factors and Mechanisms, with a Focus on Hepatic Lipoprotein Overproduction
3. Postprandial Dyslipidaemia and Intestinal Chylomicron Hypersecretion in Insulin-Resistant States
4. Low High-Density Lipoprotein in Insulin Resistance and Type 2 Diabetes
5. Treatment of the Dyslipidaemia of Insulin-Resistant States
6. Conclusions
Index
No. of pages: 612
Language: English
Edition: 6
Published: July 24, 2015
Imprint: Elsevier Science
Hardback ISBN: 9780444634382
eBook ISBN: 9780444634498
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Neale Ridgway
Dr. Neale Ridgway has made his scientific mark nationally and internationally and is a noted world expert in the synthesis, transport and regulation of two of the most abundant and important lipids in the human body – cholesterol and phosphatidylcholine His revelations about the signals and pathways that control these lipids are having a profound impact on our understanding of the origins and progression of such diseases as Alzheimer’s, atherosclerosis, cancer and lipid storage disorders. His groundbreaking work is frequently cited by other scientists in the literature, a key indicator of his influence and achievements.
Affiliations and expertise
Departments of Pediatrics and Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
RM
Roger McLeod
Dr. McLeod is a lipid researcher and studies how dietary fats are transported, broken down, stored and used in the body – and how different fats can either lead to, or prevent, chronic disease. He’s particularly interested in obesity, type 2 diabetes and cardiovascular disease, related diseases that are skyrocketing, in spite of widespread attempts to counter the deadly trends.
Affiliations and expertise
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
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