Biochemistry of Lipids, Lipoproteins and Membranes

Biochemistry of Lipids, Lipoproteins and Membranes

7th Edition - August 19, 2021
  • Editors: Neale Ridgway, Roger McLeod
  • Paperback ISBN: 9780128240489
  • eBook ISBN: 9780323983280

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Description

Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences. As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis.

Key Features

  • Fully revised to cover new and emerging topics
  • Provides an important bridge between broad-based biochemistry research and application
  • Presents key concepts that are supported by figures and models to improve understanding
  • Includes references from current literature in each chapter to facilitate in-depth study

Readership

Researchers and graduate students of biochemistry, cell biology, lipid biochemistry, and molecular biology. Clinicians and students of life science and medicine

Table of Contents

  • 1. Functional roles of lipids in biological membranes
    Mikhail Bogdanov and William Dowhan
    2. Methods of lipid analysis
    Bebiana C. Sousa, Michael J.O. Wakelam and Andrea F. Lopez-Clavijo
    3. Fatty acid and phospholipid biosynthesis in prokaryotes
    Jessica M. Gullett and Charles O. Rock
    4. Lipid metabolism in plants
    Katherine M. Schmid
    5. Fatty acid handling in mammalian cells
    Richard Lehner and Ariel D. Quiroga
    6. Fatty acid desaturation and elongation in mammals
    Lucas M. O’Neill, Makoto Miyazaki, Laura M. Bond, Sarah A. Lewis, Fang Ding, Zhaojin Liu and James M. Ntambi
    7. Phospholipid synthesis in mammalian cells
    Neale Ridgway
    8. Phospholipid catabolism
    Dakai Zhang and Guangwei Du
    9. Sphingolipids
    Anthony H. Futerman
    10. Cholesterol synthesis
    Andrew J. Brown, Hudson W. Coates and Laura J. Sharpe
    11. Structure and function of lipid droplets
    Hongyuan Yang and Jun Liu
    12. Bile acid metabolism
    Jennifer K. Truong and Paul A. Dawson
    13. Lipid modification of proteins
    Marilyn D. Resh
    14. Inter- and intra-membrane lipid transport
    Vesa M. Olkkonen and Elina Ikonen
    15. High-density lipoproteins metabolism and protective roles
    Valentin Blanchard and Gordon A. Francis
    16. Assembly and secretion of triglyceride-rich lipoproteins
    Eric A. Fisher and Roger S. McLeod
    17. Lipoprotein(a)
    Michael B. Boffa and Marlys L. Koschinsky
    18. Lipoprotein receptors
    Kristina Kuhbandner, Joachim Herz and Theresa Pohlkamp
    19. Atherosclerosis
    Murray W. Huff and Katey J. Rayner
    20. Diabetic dyslipidaemia
    Khosrow Adeli, Changting Xiao, Victoria Higgins, Jennifer Taher, Sarah Farr and Gary F. Lewis

Product details

  • No. of pages: 736
  • Language: English
  • Copyright: © Elsevier Science 2021
  • Published: August 19, 2021
  • Imprint: Elsevier Science
  • Paperback ISBN: 9780128240489
  • eBook ISBN: 9780323983280

About the Editors

Neale Ridgway

Dr. Neale Ridgway has made his scientific mark nationally and internationally and is a noted world expert in the synthesis, transport and regulation of two of the most abundant and important lipids in the human body – cholesterol and phosphatidylcholine His revelations about the signals and pathways that control these lipids are having a profound impact on our understanding of the origins and progression of such diseases as Alzheimer’s, atherosclerosis, cancer and lipid storage disorders. His groundbreaking work is frequently cited by other scientists in the literature, a key indicator of his influence and achievements.

Affiliations and Expertise

Departments of Pediatrics and Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada

Roger McLeod

Dr. McLeod is a lipid researcher and studies how dietary fats are transported, broken down, stored and used in the body – and how different fats can either lead to, or prevent, chronic disease. He’s particularly interested in obesity, type 2 diabetes and cardiovascular disease, related diseases that are skyrocketing, in spite of widespread attempts to counter the deadly trends.

Affiliations and Expertise

Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada