Biochemistry of Human Cancer

Biochemistry of Human Cancer

1st Edition - January 1, 1975

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  • Author: Oscar Bodansky
  • eBook ISBN: 9780323143639

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Biochemistry of Human Cancer focuses on advances in the application of biochemistry to the study of human cancers, such as neoplastic immunoglobulinopathies, cancer of the bladder, tumors of the neural crest, leukemias and lymphomas, and neoplasms of the bone. It also examines certain features of human cancer ranging from general metabolic characteristics to enzymic aspects and immunochemical considerations. Organized into 18 chapters, this book begins with an overview of the general metabolic features of cancer, with emphasis on the metabolism of lipids, proteins, and carbohydrates. It then discusses the important biochemical aspects of pulmonary and prostatic neoplasms, including the serum acid and alkaline phosphatase activities of prostatic carcinoma. The remaining chapters look at the role of enzymes and immunoglobulins in cancer, the tryptophan metabolism in cancer of the bladder and the carcinoid syndrome, the link between amino acid metabolism and tumors of the neural crest, and the neoplasms of the digestive tract and the accessory organs (pancreas and liver). The book explains the metabolism of purines and pyrimidines in cancer, hypercalcemia in neoplastic disease without evidence of bone metastases, and neoplasms of other organs, such as the pituitary gland, thyroid, testis, and adrenal cortex. Brief case reports from the literature are included to illustrate correlations between biochemical and clinical findings. Scientists, biochemists, and clinical investigators concerned with the biochemistry of human cancer will find this book highly informative.

Table of Contents

  • Preface

    1 General Metabolic Characteristics in Cancer

    I. Introduction

    II. Protein Metabolism

    III. Carbohydrate Metabolism

    IV. Lipid Metabolism

    V. Cachexia


    2 General Aspects of Enzymes in Cancer: The Glycolytic Sequence

    I. Introduction

    II. The Glycolytic Sequence


    3 Enzymes in Cancer: The Phosphohydrolases

    I. Introduction

    II. Acid Phosphatase

    III. Alkaline Phosphatase

    IV. 5'-Nucleotidase


    4 Miscellaneous Enzymes in Human Cancer

    I. Introduction

    II. Amylase

    III. Leucine Aminopeptidase

    IV. Serum Arylamidase

    V. Aspartate and Alanine Aminotransferases

    VI. Additional Serum Enzymes

    VII. Summary


    5 The Neoplastic Immunoglobulinopathies

    I. Introduction

    II. Human Immunoglobulins

    III. Immunoglobulins in Cancer

    IV. Multiple Myeloma (Myelomatosis)

    V. Other Immunoglobulinopathies

    VI. Biochemical Consequences of Abnormal Proteinemia

    VII. Immunological Deficits in Malignancy


    6 Tryptophan Metabolism: Cancer of the Bladder; the Carcinoid Syndrome

    I. Introduction

    II. Cancer of the Bladder

    III. Carcinoid Tumors and the Carcinoid Syndrome


    7 Amino Acid Metabolism and Tumors of the Neural Crest

    I. Introduction

    II. The Normal Tyrosine-Epinephrine, -Norepinephrine Metabolic Pathway

    III. Methionine Metabolism

    IV. Biochemistry of Pheochromocytoma and Pheochromoblastoma

    V. Biochemistry of Sympathocytoma (Ganglioneuroma) and Sympathoblastoma (Neuroblastoma)


    8 Gastrointestinal Tract, Liver, and Pancreas

    I. Introduction

    II. Neoplasms of the Stomach

    III. Neoplasms of the Small Intestine

    IV. Neoplasms of the Colon and Rectum

    V. Neoplasms of the Liver

    VI. Neoplasms of the Pancreas

    VII. Extrapancreatic Tumors Producing Hypoglycemia


    9 The Leukemias and Lymphomas

    I. Introduction

    II. Total and Isoenzyme Activity of Leukocytic Acid Phosphatase

    III. Leukocytic Alkaline Phosphatase

    IV. Lysozyme

    V. Metabolism of Purines and Pyrimidines in Cancer


    10 Neoplasms of the Bone

    I. Introduction

    II. Chemical Composition and Structure of Bone

    III. Calcium, Magnesium, and Phosphorus Metabolism in the Normal Individual

    IV. Parathyroid Adenomas and Carcinoma

    V. Primary Neoplasms of the Bone

    VI. Skeletal Metastases

    VII. Hypercalcemia in Neoplastic Disease without Evidence of Bone Metastases (Ectopic Hyperparathyroidism, Pseudohyperparathyroidism)


    11 Neoplasms of the Pituitary Gland

    I. Introduction

    II. Classification of Pituitary Tumors

    III. Acidophilic Tumors: Acromegaly and Gigantism

    IV. Cushing's Syndrome

    V. Chromophobe Adenoma

    VI. Craniopharyngiomas

    VII. Pituitary Tumors and Hypopituitarism


    12 Neoplasms of the Adrenal Cortex

    I. Introduction

    II. Steroids of the Adrenal Cortex

    III. Cushing's Syndrome

    IV. The Neoplastic Adrenogenital Syndrome

    V. Tumors of Aldosterone Excess

    VI. Nonfunctioning Adrenocortical Neoplasms


    13 Neoplasms of the Thyroid

    I. Introduction

    II. Biochemistry and Physiology of the Thyroid Hormones

    III. Biochemistry of Thyroid Neoplasms


    14 Neoplasms of the Testis

    I. Introduction

    II. Biochemistry of the Normal Testis

    III. Biochemistry of Testicular Tumors


    15 Neoplasms of the Ovary

    I. Introduction

    II. Biochemistry of the Normal Ovary

    III. Biochemistry of Ovarian Neoplasms


    16 Neoplasms and Ectopic Humoral Syndromes

    I. Introduction

    II. Syndrome Resulting from Ectopic ACTH

    III. Ectopic Melanocyte-Stimulating Hormone Syndrome

    IV. Ectopic Gonadotropic Syndrome

    V. Ectopic Antidiuretic Hormone Syndrome

    VI. Ectopic Thyrotropin Syndrome

    VII. Ectopic Syndromes Resulting from Human Chorionic Somatomammotropin, Human Placental Lactogen, and Human Growth Hormone

    VIII. Ectopic Gastrin (Zollinger-Ellison) Syndrome

    IX. Ectopic Erythropoietin Syndrome


    17 Neoplasms of the Breast

    I. Introduction

    II. Steroid Metabolism

    III. Prolactin and Carcinoma of the Breast

    IV. RNA-Dependent DNA Polymerase and RNA Homologies in Carcinoma of the Breast

    V. Other Biochemical Aspects of Breast Cancer


    18 Hydatidiform Mole, Choriocarcinoma, and Neoplasms of the Uterus

    I. Introduction

    II. Hydatidiform Mole

    III. Choriocarcinoma

    IV. Nongestational Choriocarcinoma

    V. Enzymes in Uterine Neoplasms

    VI. Hormonal Aspects of Uterine Neoplasms

    VII. Receptors in Uterine Carcinomas


    Subject Index

Product details

  • No. of pages: 672
  • Language: English
  • Copyright: © Academic Press 1975
  • Published: January 1, 1975
  • Imprint: Academic Press
  • eBook ISBN: 9780323143639

About the Author

Oscar Bodansky

Affiliations and Expertise

Sloan-Kettering Institute for Cancer Research, New York, New York

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