Biochemistry of Collagens, Laminins and Elastin - 1st Edition - ISBN: 9780128098479, 9780128098998

Biochemistry of Collagens, Laminins and Elastin

1st Edition

Structure, Function and Biomarkers

Authors: Morten Karsdal
eBook ISBN: 9780128098998
Paperback ISBN: 9780128098479
Imprint: Academic Press
Published Date: 15th August 2016
Page Count: 272
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Description

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies.

This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease.

Key Features

  • Provides a comprehensive introduction to collagen and structural proteins
  • Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation
  • Includes a chapter dedicated to the biomarkers of structural proteins
  • Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Readership

Graduate students, postdoctoral fellows, and established researchers interested in biochemistry, molecular biology, cell biology, structural biology, chemistry, and pathology

Table of Contents

  • List of Contributors
  • Preface
  • Acknowledgments
  • List of Abbreviations
  • Introduction
  • Chapter 1. Type I Collagen
    • Biomarkers of Type I Collagen
  • Chapter 2. Type II Collagen
    • Biomarkers of Type II Collagen
  • Chapter 3. Type III Collagen
    • Biomarkers of Type III Collagen
  • Chapter 4. Type IV Collagen
    • Biomarkers of Type IV Collagen
  • Chapter 5. Type V Collagen
    • Biomarkers of Type V Collagen
  • Chapter 6. Type VI Collagen
    • Biomarkers of Type VI Collagen
  • Chapter 7. Type VII Collagen
  • Chapter 8. Type VIII Collagen
    • Biomarkers of Type VIII Collagen
  • Chapter 9. Type IX Collagen
    • Biomarkers of Type IX Collagen
  • Chapter 10. Type X Collagen
    • Biomarkers of Type X Collagen
  • Chapter 11. Type XI Collagen
  • Chapter 12. Type XII Collagen
  • Chapter 13. Type XIII Collagen
    • Biomarkers of Type XIII Collagen
  • Chapter 14. Type XIV Collagen
  • Chapter 15. Type XV Collagen
  • Chapter 16. Type XVI Collagen
    • Biomarkers of Type XVI Collagen
  • Chapter 17. Type XVII Collagen
  • Chapter 18. Type XVIII Collagen
    • Role of Endostatin in Biology and Pathology
    • Biomarkers of Endostatin
  • Chapter 19. Type XIX Collagen
    • Biomarkers of Type XIX Collagen
  • Chapter 20. Type XX Collagen
  • Chapter 21. Type XXI Collagen
    • Biomarkers of Type XXI Collagen
  • Chapter 22. Type XXII Collagen
    • Biomarkers of Type XXII Collagen
  • Chapter 23. Type XXIII Collagen
    • Biomarkers of Type XXIII Collagen
  • Chapter 24. Type XXIV Collagen
  • Chapter 25. Type XXV Collagen
  • Chapter 26. Type XXVI Collagen
  • Chapter 27. Type XXVII Collagen
  • Chapter 28. Type XXVIII Collagen
  • Chapter 29. Laminins
    • Laminin-1
    • Laminin-2
    • Laminin-3
    • Laminin-4
    • Laminins-5, -6, and -7
    • Laminin-8
    • Laminin-9
    • Laminin-10
    • Laminin-11
    • Laminin-12
    • Laminins-13, -14, and -15
    • LAMA1
    • LAMA2
    • LAMA3
    • LAMA4
    • LAMA5
    • LAMB1
    • LAMB2
    • LAMB3
    • LAMC1
    • LAMC2
    • LAMC3
  • Chapter 30. Elastin
  • Chapter 31. Structural Biomarkers
    • The Convergence of Different Pathways Leads to Altered Turnover of the ECM
    • Different Classes of ECM biomarkers
    • PTMs of ECM Proteins
    • Different Matrices Mean Different things
    • Applying structural biomarkers as Diagnostic or Monitoring Tools
    • BIPED Classification in OA
    • Conclusion and Perspectives
  • Index

Details

No. of pages:
272
Language:
English
Copyright:
© Academic Press 2016
Published:
Imprint:
Academic Press
eBook ISBN:
9780128098998
Paperback ISBN:
9780128098479

About the Author

Morten Karsdal

Morten Karsdal has been CEO of Nordic Bioscience A/S since June 2010.

Since 2002, Morten Karsdal has focused his research on the discovery and development of novel biochemical markers. This has resulted in the development of more than 15 ELISA assays for detecting biomarkers that have been used for research in the fields of fibrosis, osteoporosis and osteoarthritis. One of these assays has been 510(k) approved by the Food and Drug Administration (FDA) in the USA.

Affiliations and Expertise

CEO, Nordic Bioscience A/S