Biochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies.

This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease.

• Provides a comprehensive introduction to collagen and structural proteins
• Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation
• Includes a chapter dedicated to the biomarkers of structural proteins
• Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Graduate students, postdoctoral fellows, and established researchers interested in biochemistry, molecular biology, cell biology, structural biology, chemistry, and pathology

• List of Contributors
• Preface
• Acknowledgments
• List of Abbreviations
• Introduction
• Chapter 1. Type I Collagen
  • Biomarkers of Type I Collagen
• Chapter 2. Type II Collagen
  • Biomarkers of Type II Collagen
• Chapter 3. Type III Collagen
  • Biomarkers of Type III Collagen
• Chapter 4. Type IV Collagen
  • Biomarkers of Type IV Collagen
• Chapter 5. Type V Collagen
  • Biomarkers of Type V Collagen
• Chapter 6. Type VI Collagen
  • Biomarkers of Type VI Collagen
• Chapter 7. Type VII Collagen
• Chapter 8. Type VIII Collagen
  • Biomarkers of Type VIII Collagen
• Chapter 9. Type IX Collagen
  • Biomarkers of Type IX Collagen
• Chapter 10. Type X Collagen
  • Biomarkers of Type X Collagen
• Chapter 11. Type XI Collagen
• Chapter 12. Type XII Collagen
• Chapter 13. Type XIII Collagen
  • Biomarkers of Type XIII Collagen
• Chapter 14. Type XIV Collagen
• Chapter 15. Type XV Collagen
• Chapter 16. Type XVI Collagen
  • Biomarkers of Type XVI Collagen
• Chapter 17. Type XVII Collagen
• Chapter 18. Type XVIII Collagen
  • Role of Endostatin in Biology and Pathology
  • Biomarkers of Endostatin
• Chapter 19. Type XIX Collagen
  • Biomarkers of Type XIX Collagen
• Chapter 20. Type XX Collagen
• Chapter 21. Type XXI Collagen
  • Biomarkers of Type XXI Collagen
• Chapter 22. Type XXII Collagen
  • Biomarkers of Type XXII Collagen
• Chapter 23. Type XXIII Collagen
  • Biomarkers of Type XXIII Collagen
• Chapter 24. Type XXIV Collagen
• Chapter 25. Type XXV Collagen
• Chapter 26. Type XXVI Collagen
• Chapter 27. Type XXVII Collagen
• Chapter 28. Type XXVIII Collagen
• Chapter 29. Laminins
  • Laminin-1
  • Laminin-2
  • Laminin-3
  • Laminin-4
  • Laminins-5, -6, and -7
  • Laminin-8
  • Laminin-9
  • Laminin-10
  • Laminin-11
  • Laminin-12
  • Laminins-13, -14, and -15
  • LAMA1
  • LAMA2
  • LAMA3
  • LAMA4
  • LAMA5
  • LAMB1
  • LAMB2
  • LAMB3
  • LAMC1
  • LAMC2
  • LAMC3
• Chapter 30. Elastin
• Chapter 31. Structural Biomarkers
  • The Convergence of Different Pathways Leads to Altered Turnover of the ECM
  • Different Classes of ECM biomarkers
  • PTMs of ECM Proteins
  • Different Matrices Mean Different things
  • Applying structural biomarkers as Diagnostic or Monitoring Tools
  • BIPED Classification in OA
  • Conclusion and Perspectives
• Index