Biochemical Aspects of Prostaglandins and Thromboxanes

Biochemical Aspects of Prostaglandins and Thromboxanes

Proceedings of the 1976 Intra-Science Research Foundation Symposium December 1-3, Santa Monica, California

1st Edition - January 1, 1977

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  • Editor: Norman Kharasch
  • eBook ISBN: 9780323158510

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Description

Biochemical Aspects of Prostaglandins and Thromboxanes covers the proceedings of the 1976 Intra-Science Research Foundation Symposium on New Biochemistry of Prostaglandins and Thromboxanes, held in Santa Monica, California. This 14-chapter book deals first with the biosynthesis of prostaglandins and thromboxanes with bovine vesicular gland and in transformed fibroblasts. These topics are followed by discussions on the pharmacologic properties and the role of prostaglandins as mediators of the inflammatory response. The next chapters describe the structure-activity relations and the pharmacologic activities of the prostaglandin series, with an emphasis on their role in cancer, obstetrics, and gynecology. The remaining chapters examine the role of prostaglandin endoperoxides and thromboxanes as bioregulators. This book will be of value to biochemists and pharmacologists.

Table of Contents


  • List of Participants and Speakers

    Preface

    Opening Address

    Plenary Lecture

    Enzymological Studies of Prostaglandin Biosynthesis

    Deacylation of Phospholipids: Prerequisite for Prostaglandin Synthesis by Transformed Fibroblasts

    Model Studies of Prostaglandin Biosynthesis and Pharmacological Properties of Cyclic Peroxides

    Evidence for a Pivotal Role of the Endoperoxide, PGG2, in Inflammatory Processes

    11-Deoxyprostaglandins: Synthesis and Pharmacology

    Prostaglandins as Mediators of the Hypercalcemia Associated with Certain Human Cancers

    Synthesis of Thromboxanes

    Newer Aspects of Practical Applications of Prostaglandins in Obstetrics and Gynaecology

    The Role of Prostaglandin Endoperoxides and Thromboxanes as Bioregulators

    The Discovery of Prostacyclin—A Fresh Insight into Arachidonic Acid Metabolism

    The Structure of Prostaglandin I2

    Experimental Stroke and Heart Attack Induced by Thromboxane A2 Mixture and Their Prevention by Thromboxane A2 Antagonistic Substance, EG626

    Biological and Chemical Characterization of a Unique Endogenous Vasodilator Prostaglandin Produced in Isolated Coronary Artery and in Intact Perfused Heart

    Synthesis and Biological Studies of Luteolytic 13-Dehydroprostaglandins

    Index

Product details

  • No. of pages: 268
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: January 1, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323158510

About the Editor

Norman Kharasch

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