Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System

Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System

Proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System, Naples, Italy, May 1978

1st Edition - January 1, 1979

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  • Editors: Vincenzo Zappia, Earl Usdin, Francesco Salvatore
  • eBook ISBN: 9781483159874

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Description

Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System contains the proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System held in Naples, Italy, on May 2, 1978. The papers explore the biochemical and pharmacological roles of S-adenosylmethionine (SAM), with particular emphasis on its functions in the central nervous system (CNS). This book consists of 13 chapters and opens with an introduction to some novel biochemical aspects of SAM and related sulfur compounds, paying particular attention to transmethylation reactions; polyamine biosynthesis and unusual biological roles of adenosylmethionine; metabolic pathways related to adenosine-sulfur compounds; and transport of adenosylmethionine. The following chapters discuss a number of chemical and biochemical properties of SAM as well as its pharmacological aspects within the CNS. The relation between folate and adenosylmethionine metabolism in the brain is examined, along with the effect of SAM administration on noradrenaline and serotonin metabolism in rat brain; cerebral utilization of adenosylmethionine and adenosylhomocysteine; and antidepressant effects of adenosylmethionine. Methylation in schizophrenia is also considered. This monograph will be a valuable source of information for biochemists and pharmacologists.

Table of Contents


  • Preface

    Abbreviations

    Contributors

    Novel Aspects in the Biochemistry of Adenosylmethionine and Related Sulfur Compounds

    The Chemical Properties of Sulfonium Compounds

    Analysis and Distribution of Adenosylmethionine and Adenosylhomocysteine in Mammalian Tissues

    Protein Methylation: Perspectives in Central Nervous System

    The Relation between Folate and Adenosylmethionine Metabolism in Brain

    Dietary Influences on Brain Neurotransmitter Synthesis and Brain Methylation Reactions

    Changes in Rat Brain Noradrenaline and Serotonin Metabolism after Administration of S-Adenosylmethionine

    Cerebral Utilization of Adenosylmethionine and Adenosylhomocysteine: Effects of Methionine Sulfoximine

    Studies on Indoleamine N-Methyltransferase, an Enzyme Possibly Involved in Psychotic Disorders

    Action of S-Adenosylmethionine on the Hypothalamic - Hypophyseal - Prolactin Axis

    Methylation in Schizophrenia: An Old Hypothesis Revisited

    Antidepressant Effects of Adenosylmethionine: Clinical and Methodological Issues Emerging from Preliminary Trials

    Adenosylmethionine and Chronic Ammonia Intoxication

    Subject Index

    Author Index

Product details

  • No. of pages: 184
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: January 1, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483159874

About the Editors

Vincenzo Zappia

Earl Usdin

Francesco Salvatore

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