Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System - 1st Edition - ISBN: 9780080249292, 9781483159874

Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System

1st Edition

Proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System, Naples, Italy, May 1978

Editors: Vincenzo Zappia Earl Usdin Francesco Salvatore
eBook ISBN: 9781483159874
Imprint: Pergamon
Published Date: 1st January 1979
Page Count: 184
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Description

Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System contains the proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System held in Naples, Italy, on May 2, 1978. The papers explore the biochemical and pharmacological roles of S-adenosylmethionine (SAM), with particular emphasis on its functions in the central nervous system (CNS). This book consists of 13 chapters and opens with an introduction to some novel biochemical aspects of SAM and related sulfur compounds, paying particular attention to transmethylation reactions; polyamine biosynthesis and unusual biological roles of adenosylmethionine; metabolic pathways related to adenosine-sulfur compounds; and transport of adenosylmethionine. The following chapters discuss a number of chemical and biochemical properties of SAM as well as its pharmacological aspects within the CNS. The relation between folate and adenosylmethionine metabolism in the brain is examined, along with the effect of SAM administration on noradrenaline and serotonin metabolism in rat brain; cerebral utilization of adenosylmethionine and adenosylhomocysteine; and antidepressant effects of adenosylmethionine. Methylation in schizophrenia is also considered. This monograph will be a valuable source of information for biochemists and pharmacologists.

Table of Contents


Preface

Abbreviations

Contributors

Novel Aspects in the Biochemistry of Adenosylmethionine and Related Sulfur Compounds

The Chemical Properties of Sulfonium Compounds

Analysis and Distribution of Adenosylmethionine and Adenosylhomocysteine in Mammalian Tissues

Protein Methylation: Perspectives in Central Nervous System

The Relation between Folate and Adenosylmethionine Metabolism in Brain

Dietary Influences on Brain Neurotransmitter Synthesis and Brain Methylation Reactions

Changes in Rat Brain Noradrenaline and Serotonin Metabolism after Administration of S-Adenosylmethionine

Cerebral Utilization of Adenosylmethionine and Adenosylhomocysteine: Effects of Methionine Sulfoximine

Studies on Indoleamine N-Methyltransferase, an Enzyme Possibly Involved in Psychotic Disorders

Action of S-Adenosylmethionine on the Hypothalamic - Hypophyseal - Prolactin Axis

Methylation in Schizophrenia: An Old Hypothesis Revisited

Antidepressant Effects of Adenosylmethionine: Clinical and Methodological Issues Emerging from Preliminary Trials

Adenosylmethionine and Chronic Ammonia Intoxication

Subject Index

Author Index

Details

No. of pages:
184
Language:
English
Copyright:
© Pergamon 1979
Published:
Imprint:
Pergamon
eBook ISBN:
9781483159874

About the Editor

Vincenzo Zappia

Earl Usdin

Francesco Salvatore